DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf4

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_033449.2	Gene:	Traf4 / 22032	MGIID:	1202880	Length:	470	Species:	Mus musculus

Alignment Length:	465	Identity:	96/465 - (20%)
Similarity:	155/465 - (33%)	Gaps:	152/465 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HLIHCGQVLEECPNGCQAFIPRIRMRSHLK-ECPRNQHNLSNQQRMSVSMDRLDRQSD------- 112
            ||..|...:..|||.|.|.:.|..:.:||: :||:        :|:.......|...:
Mouse   102 HLNTCSFNVVPCPNRCPAKLSRRDLPAHLQHDCPK--------RRLKCEFCGCDFSGEAYESHEG 158

  Fly   113 ---QRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRKQNQVVEDWTRETEKAMDDLRRQMEEE 174
               |..:..|...|.       .:.:||              :.:..|.|..|     |.|
Mouse   159 VCPQESVYCENKCGA-------RMMRRL--------------LAQHATSECPK-----RTQ---- 193

  Fly   175 TNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKLEELI 239
                         ...||      .||.|...:...|....:|....   .||.....:
Mouse   194 -------------PCAYC------TKEFVYDTIQSHQYQCPRLPVPC---PNQCGVGTV------ 230

  Fly   240 FENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEE-----RC 299
                                ..||:.|.|.:|              .:...::|..:|     ||
Mouse   231 --------------------AREDLPTHLKDS--------------CSTAFVLCPFKESGCKHRC 261

  Fly   300 DKLDRALHQTMQNISDLETQMAMQQRIAS-----VQNIR-----------GHLIWRIKDYSKKLE 348
            .||....|..    ..::..:||...:.|     :|.:|           |.|||:|..|.::|:
Mouse   262 PKLAMGRHVE----ESVKPHLAMMCALVSRQRQELQELRRELEELSIGSDGVLIWKIGSYGRRLQ 322

  Fly   349 ESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWPCRLQAE 412
            |:|....: ..|..|....:||.|::..:|||.|:.:|.::...:.||.|.:|.||.||...:..
Mouse   323 EAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSIYIRVLPGAFDNLLEWPFARRVT 387

  Fly   413 IIIRDQC-TNVADAEDYVKTIFVRKKSDDF----------IQSNQYFHIP----HKVITSRNYLR 462
            ..:.||. ..:|..:...:|........:|          .:|:..|..|    |:.|..|||:|
Mouse   388 FSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVR 452

  Fly   463 NDSMFIEVRV 472
            :|::||...|
Mouse   453 DDAVFIRASV 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	11/32 (34%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	45/155 (29%)
Traf4	NP_033449.2	mRING-HC-C3HC3D_TRAF4	15..59	CDD:319555
		modified RING-HC finger (C3HC3D-type)	18..57	CDD:319555
		zf-TRAF	102..156	CDD:280357	15/61 (25%)
		zf-TRAF	210..269	CDD:280357	15/101 (15%)
		MATH_TRAF4	308..463	CDD:239750	45/155 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810