DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf2

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001277342.1	Gene:	Traf2 / 22030	MGIID:	101835	Length:	508	Species:	Mus musculus

Alignment Length:	461	Identity:	108/461 - (23%)
Similarity:	186/461 - (40%)	Gaps:	101/461 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TIVKYEKSSCLFCNEWFDAQTFTEHLIHCGQVLEECPNGCQAFIPRIRMRSH--LKECPRNQHNL 94
            |:.:||.     |:|..           |..:|.||| .|:..: |:..:.|  .:|||:  .:|
Mouse   124 TLKEYES-----CHEGL-----------CPFLLTECP-ACKGLV-RLSEKEHHTEQECPK--RSL 168

  Fly    95 SNQQ-RMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITD-VGNIRKQNQVVEDWT 157
            |.|. |...|...|:                    ::.|:..:..|..| .|..:...:..:|..
Mouse   169 SCQHCRAPCSHVDLE--------------------VHYEVCPKFPLTCDGCGKKKIPRETFQDHV 213

  Fly   158 RETEKAMDDLR------RQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLD---EAQKL 213
            |...|.....|      .:|.|..|     ::.::|         |.|:|.:...|.   |||..
Mouse   214 RACSKCRVLCRFHTVGCSEMVETEN-----LQDHEL---------QRLREHLALLLSSFLEAQAS 264

  Fly   214 VNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTSKQ 278
            ...|        ||:...:|:..:::       .:|....|..:..:|.::: ::..:....|:|
Mouse   265 PGTL--------NQVGPELLQRCQIL-------EQKIATFENIVCVLNREVE-RVAVTAEACSRQ 313

  Fly   279 ATLDYE-VKNVKNIVCETEERCDKLDRALHQTMQNISDLETQMAMQQRIASVQNIRGHLIWRIKD 342
            ..||.: ::.:.|.|.:.|......|.|:....|.:|:||           |....|..||:|.|
Mouse   314 HRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSELE-----------VSTYDGVFIWKISD 367

  Fly   343 YSKKLEESKQYDT-ILHSAMFSNKAFGYALRLDIYLNGKGTWKGRNMIACLNVLSGEYDPLLAWP 406
            :::|.:|:....| .:.|..|....:||.:.|.:||||.||.:|.::.....|:.|..|.||.||
Mouse   368 FTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWP 432

  Fly   407 CRLQAEIIIRDQCT--NVADA--EDYVKTIFVRKKSDDFIQSNQYFHIPHKVITSRN-YLRNDSM 466
            ...:..:::.|...  :|.||  .|...:.|.|..||..|.|......|...:.::| |:|:|::
Mouse   433 FNQKVTLMLLDHNNREHVIDAFRPDVTSSSFQRPVSDMNIASGCPLFCPVSKMEAKNSYVRDDAI 497

  Fly   467 FIEVRV 472
            ||:..|
Mouse   498 FIKAIV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	9/35 (26%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	46/145 (32%)
Traf2	NP_001277342.1	zf-C3HC4	34..79	CDD:278524
		zf-TRAF	185..242	CDD:280357	11/61 (18%)
		TRAF_BIRC3_bd	274..336	CDD:293278	11/69 (16%)
		Important for interaction with BIRC2 and BIRC3	290..300		2/9 (22%)
		MATH_TRAF2	341..504	CDD:239747	52/174 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910