DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and Traf1

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001313530.1	Gene:	Traf1 / 22029	MGIID:	101836	Length:	409	Species:	Mus musculus

Alignment Length:	354	Identity:	80/354 - (22%)
Similarity:	138/354 - (38%)	Gaps:	102/354 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VVEDWTRE-----------TEKAMDDLRRQ--------MEEETNRKAFAIEQNQLDVQYCCDITQ 197
            |:::|...           .|:.:.:|:.|        :|.:..|......|.:|.:|:.  :.:
Mouse   115 VLKEWKSSPGSNLGSAPMALERNLSELQLQAAVEATGDLEVDCYRAPCCESQEELALQHL--VKE 177

  Fly   198 SLKEQVESRLDEAQKLVNQLSADV---------TYHQNQLN-DNILKLEELIFENERLNREKFFQ 252
            .|..|:|.:|.....:|..|:.:|         :.||:||: ::||.||:.:.|
Mouse   178 KLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVE----------- 231

  Fly   253 IEEFLQQINEDIKTKLGNSDYVTSKQATLDYEVKNVKNIVCETEERCDKLDRALHQTMQNISDLE 317
                |||       .|...|.|..                        ||:.:|
Mouse   232 ----LQQ-------TLAQKDQVLG------------------------KLEHSL----------- 250

  Fly   318 TQMAMQQRIASVQNIRGHLIWRIKDYSKKLEESKQYDTI-LHSAMFSNKAFGYALRLDIYLNGKG 381
                   |:....:..|..:|:|.:.:|:..||....|: |.|..|....:||.|.|.:||||.|
Mouse   251 -------RLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDG 308

  Fly   382 TWKGRNMIACLNVLSGEYDPLLAWPCRLQAEIIIRDQCT--NVADA--EDYVKTIFVRKKSDDFI 442
            :.|..::...:.::.||||.||.||.|.:...::.||..  :..||  .|.....|.|.:|:..:
Mouse   309 SGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNV 373

  Fly   443 QSNQYFHIPHKVITS--RNYLRNDSMFIE 469
            .|......|...:.|  ..|:::|:||::
Mouse   374 ASGCPLFFPLSKLQSPKHAYVKDDTMFLK 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	44/143 (31%)
Traf1	NP_001313530.1	SMC_prok_B	<126..257	CDD:274008	34/196 (17%)
		TRAF_BIRC3_bd	180..237	CDD:374713	18/78 (23%)
		MATH_TRAF1	260..406	CDD:239748	44/143 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10131
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910