DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf-like and RNF41

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001229755.1	Gene:	RNF41 / 10193	HGNCID:	18401	Length:	317	Species:	Homo sapiens

Alignment Length:	316	Identity:	63/316 - (19%)
Similarity:	111/316 - (35%)	Gaps:	116/316 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FCN----EWFDAQ---------TFTEHLIHCGQVLEE--------CPN---GCQAFIPRIRMRSH 83
            |||    :||..|         ....||....:::..        |.|   ||.|.:....:.||
Human    38 FCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSH 102

  Fly    84 LKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNEEIRQRLHLITDVGNIRK 148
            |.:|   :||                  .:|.:..||..|.  .:..:|:... :.|..:.::.:
Human   103 LSDC---EHN------------------PKRPVTCEQGCGL--EMPKDELPNH-NCIKHLRSVVQ 143

  Fly   149 QNQVVEDWTR--ETEKAMDDLRRQMEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQ 211
            |.|     ||  |.||...:.:.|:.|:           :.|:|    :.::....:.|
Human   144 QQQ-----TRIAELEKTSAEHKHQLAEQ-----------KRDIQ----LLKAYMRAIRS------ 182

  Fly   212 KLVNQLSADVTYHQNQLNDNILKLEELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTS 276
                            :|.|:..|||.|..||         |.|::..:.....|:.|.  .:::
Human   183 ----------------VNPNLQNLEETIEYNE---------ILEWVNSLQPARVTRWGG--MIST 220

  Fly   277 KQATLDYEVKNVKNIVCETEERC-----DKLDRALHQTM--QNISDLETQMAMQQR 325
            ..|.|...:|  :::|   |..|     ::|....|:..  |.::.|||:. |.:|
Human   221 PDAVLQAVIK--RSLV---ESGCPASIVNELIENAHERSWPQGLATLETRQ-MNRR 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	10/44 (23%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168
RNF41	NP_001229755.1	mRING-HC-C3HC3D_Nrdp1	15..57	CDD:319548	6/18 (33%)
RNF41	NP_001229755.1	USP8_interact	137..315	CDD:401040	38/193 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900