DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Traf-like and pdzrn3b

DIOPT Version :9

Sequence 1:	NP_727976.1	Gene:	Traf-like / 32611	FlyBaseID:	FBgn0030748	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_001243321.1	Gene:	pdzrn3b / 100005518	ZFINID:	ZDB-GENE-071022-4	Length:	1053	Species:	Danio rerio

Alignment Length:	443	Identity:	74/443 - (16%)
Similarity:	146/443 - (32%)	Gaps:	149/443 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SSRKDLTEQNQYQNQNENQNQPKSTTIVKYEKSSCL-----FCNEWFDAQTFTEHLIHCGQVLEE 66
            |::.|:|    :|:.......|.|:|.|...:...|     ..:|:||...|.|
Zfish   356 STQTDIT----FQHIMALSKLPTSSTPVDVLEQYLLPEGHSPAHEYFDPNDFLE----------- 405

  Fly    67 CPNGCQAFIPRIRMRSHLKECPRNQHNLSNQQRMSVSMDRLDRQSDQRLLVIEQDVGTIRSVLNE 131
               |.|..|.|..:  ..:|....:.|:.::...:|.. |.|.:.:..:.|.|.|..:| :..:.
Zfish   406 ---GMQHEIEREEL--EYEEVDLYRTNIHDKLGFTVCY-RTDDEDETGIYVSEIDPNSI-AAKDG 463

  Fly   132 EIRQRLHLITDVGNIRKQN-------------------------QVVEDWTRETEK-AMDDLRRQ 170
            .||:...:| .:..|..||                         |:.|.|..:... .:|||...
Zfish   464 RIREGDRII-QINGIEIQNREEAVALLTSEEHPNVCLLLARPEIQLDEGWMDDDRNDYLDDLHMD 527

  Fly   171 MEEETNRKAFAIEQNQLDVQYCCDITQSLKEQVESRLDEAQKLVNQLSADVTYHQNQLNDNILKL 235
            |.|:.:.:|         :|:...:.|..|.:.:....:...|::        |.::.:..:.:.
Zfish   528 MLEQQHHQA---------MQFTASVLQQKKHEEDGSTTDTATLLS--------HHHEKDSGVGRT 575

  Fly   236 EELIFENERLNREKFFQIEEFLQQINEDIKTKLGNSDYVTSKQATL---------------DY-- 283
            ::....:|...:|.       |........|.||:...:...|.||               ||
Zfish   576 DDSTRNDESSEQEN-------LADDQTSASTTLGSRRRLAYSQDTLGSGDLPFSSESFISADYAD 633

  Fly   284 -------------EVKNVKNIVCET------------------------EERCDKLDRALHQTMQ 311
                         ..:.:..:.|:.                        ||..||....|::.::
Zfish   634 AEFLGDFPADECERFRELLELKCQMQSAGSSGTPDQSLLWPSGGQGGVGEEGVDKELELLNEELR 698

  Fly   312 NISDLETQMAMQQRIASVQNIRGHLIWRIKDYSKKLEESKQYDTILHSAMFSN 364
            :| :||          .:..:|.|.:.:::      |:.::...:||::.|.|
Zfish   699 SI-ELE----------CLSIVRAHRMQQLR------EQCREQSWMLHNSGFRN 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf-like	NP_727976.1	zf-TRAF_2	<54..88	CDD:292587	6/33 (18%)
Traf-like	NP_727976.1	MATH_TRAF_C	334..473	CDD:238168	6/31 (19%)
pdzrn3b	NP_001243321.1	RING	17..58	CDD:238093
		PDZ	245..337	CDD:214570
		PDZ_signaling	421..489	CDD:238492	14/70 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..604		7/55 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900