Protein Alignment CG18858 and LCAT

DIOPT Version :10

• Sequence 1: NP_652700.1
• Gene: CG18858 / 326109
• FlyBaseID: FBgn0042175
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_000220.1
• Gene: LCAT / 3931
• HGNCID: 6522
• Length: 440
• Species: Homo sapiens
• Alignment Length: 409
• Identity: 136/409 - (33%)
• Similarity: 206/409 - (50%)
• Gaps: 4/409 - (0%)

  Fly    11 LLLTTFLALGECFWPFSKWHGRNDNPSAPPEPKLSPVIFVPGDGGSQMDARLNKPNSPYLIC-QK 74
            |||...|.....||..:.....:..|.|.......|||.|||..|:|::|:|:||:....:| :|
Human    13 LLLGLLLPPAAPFWLLNVLFPPHTTPKAELSNHTRPVILVPGCLGNQLEAKLDKPDVVNWMCYRK 77

  Fly    75 THDWYNLWLDLEQLVIPMVYCWIDNVKLYYDKVTRTTHNTPGVETRIPGWGNPEVVEWIDPTKNS 139
            |.|::.:||||...:...|.|||||.::.|::.:....|.|||:.|:||:|....||::|.:|
Human    78 TEDFFTIWLDLNMFLPLGVDCWIDNTRVVYNRSSGLVSNAPGVQIRVPGFGKTYSVEYLDSSK-- 140

  Fly   140 AGAYFKDIANELVKLGYIRKQNIHGAPYDFRKAPNENQQFFIDLKQLVEDSYEANNQSAVTFISH 204
            ...|...:...||..||:|.:.:..||||:|..|.:.::::..|..|||:.:.|..: .|..|.|
Human   141 LAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLEPGQQEEYYRKLAGLVEEMHAAYGK-PVFLIGH 204

  Fly   205 SMGSLMTLVFLQEQTLQWKAKYVKRMISLAGVWAGSFKAVKVFAMGDDLDSFALSAKILKAEQIT 269
            |:|.|..|.||..|...||.:::...|||...|.||.|.:.|.|.||:.....:|:..||.||..
Human   205 SLGCLHLLYFLLRQPQAWKDRFIDGFISLGAPWGGSIKPMLVLASGDNQGIPIMSSIKLKEEQRI 269

  Fly   270 HPSTAWLLPSPLFWKPSEVLAMTPSRNYTMAQLEEFFKDLDYMTGWEMRKDTIRYNRNFDPPNVE 334
            ..::.|:.||.:.|....|...|||.|||....:.||.||.:..||.|...:.........|.||
Human   270 TTTSPWMFPSRMAWPEDHVFISTPSFNYTGRDFQRFFADLHFEEGWYMWLQSRDLLAGLPAPGVE 334

  Fly   335 LHCLYGEGIDTVERLQYKKSDISGETPKLIMGLGDGTVNQRSLRACKYWAGYSKAPINTLALQNV 399
            ::||||.|:.|.....|.......:...::...||.||..||...|..|.|....|::.|.|..:
Human   335 VYCLYGVGLPTPRTYIYDHGFPYTDPVGVLYEDGDDTVATRSTELCGLWQGRQPQPVHLLPLHGI 399

  Fly   400 DHLHILSNPDVLKYIRTVM 418
            .||:::.:...|::|..::
Human   400 QHLNMVFSNLTLEHINAIL 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18858	NP_652700.1	alpha/beta hydrolases	81..405	CDD:473884	110/323 (34%)
LCAT	NP_000220.1	LCAT	83..408	CDD:396835	110/327 (34%)