DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ALA3

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_176191.1	Gene:	ALA3 / 842275	AraportID:	AT1G59820	Length:	1213	Species:	Arabidopsis thaliana

Alignment Length:	1369	Identity:	408/1369 - (29%)
Similarity:	630/1369 - (46%)	Gaps:	319/1369 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SGFRRIDRLGAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQIQIGGP-------QDIKK 67
            ||...:|....|::||                    ||..|:.   .||...|       .|.:.
plant     4 SGSFSVDSSATHQRTP--------------------SRTVTLG---HIQPQAPTYRTVYCNDRES 45

  Fly    68 KRP---KGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFV 129
            .:|   || |.|.:|||.:.||||:.|.||||||||.|||.::.:|:...|||||:|::.||..|
plant    46 NQPVRFKG-NSISTTKYNVFTFLPKGLFEQFRRIANIYFLGISCLSMTPISPVSPITNVAPLSMV 109

  Fly   130 IAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLR 194
            :.|:..|:.:||..|::.|..:|:|.|.:::|.:...|..:.:..|:::.:::|...|.|::.:.
plant   110 LLVSLIKEAFEDWKRFQNDMSINNSTVEILQDQQWVSIPWRKLQVGDIVKIKKDGFFPADILFMS 174

  Fly   195 STDPHGKCFITTANLDGESNLKTLMVPRDLP-TVD--LPE--MHKLGIIECESPTTDLYSFNGKI 254
            ||:..|.|::.|||||||:|||   :.:.|. |.|  :||  ....|.|:||.|...||:|.|.:
plant   175 STNSDGICYVETANLDGETNLK---IRKALERTWDYLVPEKAYEFKGEIQCEQPNNSLYTFTGNL 236

  Fly   255 ELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFL 319
            .:   :.:.||||.:.:||||..::|||.::|..|:||..:|:.:|:....:|.::.|..:::.:
plant   237 VV---QKQTLPLSPDQLLLRGCSLRNTEYIVGAVVFTGHETKVMMNAMNAPSKRSTLEKKLDKLI 298

  Fly   320 IVILVALI----------AIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQ----DYLSF 370
            |.|...|:          :|||     .|.::        |||.....:..:..|.    .:.:.
plant   299 ITIFCVLVTMCLIGAIGCSIVT-----DREDK--------YLGLHNSDWEYRNGLMIGFFTFFTL 350

  Fly   371 LILFNYLIPISLYVTIELQRVIGS-WFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKT 434
            :.||:.:|||||||:||:.:.|.| .|:..||.:|..||:.|....||||||||||:..:|||||
plant   351 VTLFSSIIPISLYVSIEMIKFIQSTQFINRDLNMYHAETNTPASARTSNLNEELGQVEYIFSDKT 415

  Fly   435 GTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSL 499
            ||||:|.|.|.:|||.|                                        |....|
plant   416 GTLTRNLMEFFKCSIGG----------------------------------------VSYGCG-- 438

  Fly   500 EQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIIS 564
                        ||.|:.|          ..:.|....|.|
plant   439 ------------VTEIEKG----------IAQRHGLKVQEE------------------------ 457

  Fly   565 SDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFR 629
                                              :.:.||..:...|..||..
plant   458 ----------------------------------QRSTGAIREKGFNFDDPRL------------ 476

  Fly   630 PISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR 694
                          ::.:|.               ..||..|...          |||..:...
plant   477 --------------MRGAWR---------------NEPNPDLCKE----------LFRCLAICH- 501

  Fly   695 ESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL 759
                        |:|...:....|         :.|||:||||.|||.|..|.|..:.......:
plant   502 ------------TVLPEGDESPEK---------IVYQAASPDEAALVTAAKNFGFFFYRRTPTMV 545

  Fly   760 RVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCA 824
            .||  ..|::   ...|.::..::.|:||||.|.|||.||:.|..||:..:|.|||::.:|...|
plant   546 YVR--ESHVE---KMGKIQDVAYEILNVLEFNSTRKRQSVVCRFPDGRLVLYCKGADNVIFERLA 605

  Fly   825 NSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKI 889
            |...::...|..|:..|...|||||.:|.:.::.|.|..:..:..||.|:|.:|::..:|....|
plant   606 NGMDDVRKVTREHLEHFGSSGLRTLCLAYKDLNPETYDSWNEKFIQAKSALRDREKKLDEVAELI 670

  Fly   890 ESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYF-- 952
            |.:|.|:|:||:||.||:.|...:.:|..||||||||||||:|||:|||.:|..|..:.|::.
plant   671 EKDLILIGSTAIEDKLQEGVPTCIETLSRAGIKIWVLTGDKMETAINIAYACNLINNEMKQFVIS 735

  Fly   953 -----IMECKNR---------------EEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEA 997
                 |.|.:.|               .|:...|......:....|.:.:|:||||.|..||
plant   736 SETDAIREAEERGDQVEIARVIKEEVKRELKKSLEEAQHSLHTVAGPKLSLVIDGKCLMYAL--- 797

  Fly   998 SSEFR----DVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIG 1058
            ....|    .:::.||:|:|||:|||||::|.||::...:.. |.|||||||||||||.||||||
plant   798 DPSLRVMLLSLSLNCTSVVCCRVSPLQKAQVTSLVRKGAQKI-TLSIGDGANDVSMIQAAHVGIG 861

  Fly  1059 IMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLF 1123
            |.|.||.||...:|||.|:|..|..||||||.:..:|:..:|:||||||:.|....|.|.|.|.|
plant   862 ISGMEGMQAVMASDFAIAQFRFLTDLLLVHGRWSYLRICKVVMYFFYKNLTFTLTQFWFTFRTGF 926

  Fly  1124 SSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLF 1188
            |....||..|.:|:||::|:||::.:.:.||..:.....|.|:||::...|....|....:|...
plant   927 SGQRFYDDWFQSLFNVVFTALPVIVLGLFEKDVSASLSKRYPELYREGIRNSFFKWRVVAVWATS 991

  Fly  1189 AIYHSVIIFYF--AFCFFYYNNVLLNYG----QTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSF 1247
            |:|.|::.:.|  ...|...|:....:|    .|:.|:|        :|:.||:::.|.|..::.
plant   992 AVYQSLVCYLFVTTSSFGAVNSSGKVFGLWDVSTMVFTC--------LVIAVNVRILLMSNSITR 1048

  Fly  1248 WYIFTIIISILGFVVTTVIYNVINLDYD--TDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIR 1310
            |:..|:..|||.::|...:|..|...:|  .::|:....|:::...:..:::..:..|:.|:..:
plant  1049 WHYITVGGSILAWLVFAFVYCGIMTPHDRNENVYFVIYVLMSTFYFYFTLLLVPIVSLLGDFIFQ 1113

  Fly  1311 MLQR 1314
            .::|
plant  1114 GVER 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	34/73 (47%)
		ATPase-Plipid	74..1317	CDD:273734	392/1295 (30%)
		E1-E2_ATPase	127..>345	CDD:278548	70/232 (30%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	24/29 (83%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	74/255 (29%)
ALA3	NP_176191.1	ATPase-Plipid	51..1129	CDD:273734	394/1299 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820