DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4301 and ATP8B4

DIOPT Version :9

Sequence 1:NP_573125.1 Gene:CG4301 / 32610 FlyBaseID:FBgn0030747 Length:1342 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1363 Identity:403/1363 - (29%)
Similarity:627/1363 - (46%) Gaps:354/1363 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 RVSTINDWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISL 111
            |:...||         ::..:|.....|||.::||.::||||.||.|||:|:||.|||.:.|:.|
Human    50 RIVKAND---------REYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQL 105

  Fly   112 LID-SPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPG 175
            :.: |.::..|:::|||.||.:||.|...:|..|:::||.||:....|:.:.|....|..:|..|
Human   106 IPEISSLTWFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVG 170

  Fly   176 ELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVD---------LPE 231
            ::|.:|.:..|..||:||.|::|||.|::.||.|||     :|...:|:|.|:         ||.
Human   171 DIIKLENNQFVAADLLLLSSSEPHGLCYVETAELDG-----SLCCYKDVPWVECQLFGAQEALPT 230

  Fly   232 M----------HKL-----------------GIIECESPTTDLYSFNGKIELKGGEGRVLPLSTE 269
            .          |.|                 ||:.||.|...|..|.|.:..|..:.   .|:.|
Human   231 FLKQETNLKVRHALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKH---SLNNE 292

  Fly   270 NVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIVTLL- 333
            .::|||..::||....|..::.|..:||..||..|:.|..|.:..:|..::.|...||.:..:| 
Human   293 KIILRGCILRNTSWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILA 357

  Fly   334 ----YFLKRYNELFVIPKLTYL----GDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQR 390
                .:..:..:.|    .|:|    |:.:..:|  .|| .:.|::|:.|.::||||||::|:.|
Human   358 IGNSIWESQTGDQF----RTFLFWNEGEKSSVFS--GFL-TFWSYIIILNTVVPISLYVSVEVIR 415

  Fly   391 VIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF- 454
            :..|:|:.||.::|.:....|.|..|:.||||||||..:|||||||||:|.|.|::|||||..: 
Human   416 LGHSYFINWDRKMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYG 480

  Fly   455 -----LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTA 514
                 |.:||.:..|:......:...:..:..||..    |.::                    :
Human   481 EVHDDLDQKTEITQEKEPVDFSVKSQADREFQFFDH----HLME--------------------S 521

  Fly   515 IKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGV 579
            ||.|.|:::....:            |.:.||:                                
Human   522 IKMGDPKVHEFLRL------------LALCHTV-------------------------------- 542

  Fly   580 ERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDL 644
                                                                             
Human   543 ----------------------------------------------------------------- 542

  Fly   645 QQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTIL 709
             .|.|..:|:                                                       
Human   543 -MSEENSAGE------------------------------------------------------- 551

  Fly   710 VRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPF 774
                              |.||..||||.|||.|..|.|.::.....||:.:             
Human   552 ------------------LIYQVQSPDEGALVTAARNFGFIFKSRTPETITI------------- 585

  Fly   775 AKPREE-----TFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKT 834
                ||     |:|.|..|:|.:.|||||||||:.:|:..:|:|||::.:|.....|:..|::.|
Human   586 ----EELGTLVTYQLLAFLDFNNTRKRMSVIVRNPEGQIKLYSKGADTILFEKLHPSNEVLLSLT 646

  Fly   835 DAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGAT 899
            ..|:|:||..||||||||.|.:.::.::::...|..||::.|.|.:.....|.:||.:|.|||||
Human   647 SDHLSEFAGEGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDERIAGLYEEIERDLMLLGAT 711

  Fly   900 AVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKN----RE 960
            ||||.||:.|.:|:.||..|.||||||||||.|||:||..:|..:..|....|::...|    ||
Human   712 AVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLTDDMNDVFVIAGNNAVEVRE 776

  Fly   961 EM-------------------------LLHLNALDREIIFGIGQECALLIDGKSLGVAL-AEASS 999
            |:                         .|.|:::..|.|.|   :.||:|:|.||..|| ::..:
Human   777 ELRKAKQNLFGQNRNFSNGHVVCEKKQQLELDSIVEETITG---DYALIINGHSLAHALESDVKN 838

  Fly  1000 EFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREG 1064
            :..::|..|..|:|||::||||::||.|:| ...|..|.:|||||||||||:.||:|:||.|:||
Human   839 DLLELACMCKTVICCRVTPLQKAQVVELVK-KYRNAVTLAIGDGANDVSMIKSAHIGVGISGQEG 902

  Fly  1065 RQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVY 1129
            .||...:|::||:|..|:|||||||.:...|:...:.||||||..|..:.|.|.|...||:.:||
Human   903 LQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVY 967

  Fly  1130 DSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSV 1194
            |..|:||:|::|||||:|.:.|.::..:::..:..|||||....|...:...|.:.||..||.|:
Human   968 DQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNLLFNKRKFFICVLHGIYTSL 1032

  Fly  1195 IIFYFAFCFFYYNNVLLNYGQTVA-FSCFGTLLMWTVVVVVNLKLWLESMYLSF------WYIFT 1252
            ::|:..:..||  ||....||.:| :..|...:..::|:||::::.|::.|.:|      |....
Human  1033 VLFFIPYGAFY--NVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALDTSYWTFINHVFIWGSIA 1095

  Fly  1253 IIISILGFVVTTVIYNVINLDYDTDIYWAYN--NLLASLPVWLWIIVTCVACLVPDYTIRMLQ 1313
            |..|||..:.:..|:.:    :.....:..|  :.|....:||.|::|.||.::|....|.|:
Human  1096 IYFSILFTMHSNGIFGI----FPNQFPFVGNARHSLTQKCIWLVILLTTVASVMPVVAFRFLK 1154

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4301NP_573125.1 PhoLip_ATPase_N 57..121 CDD:292826 24/64 (38%)
ATPase-Plipid 74..1317 CDD:273734 399/1336 (30%)
E1-E2_ATPase 127..>345 CDD:278548 73/258 (28%)
Cation_ATPase <734..823 CDD:289987 34/93 (37%)
HAD_like <1036..1066 CDD:304363 20/29 (69%)
PhoLip_ATPase_C 1068..1317 CDD:292829 83/255 (33%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 26/73 (36%)
ATPase-Plipid 65..1167 CDD:273734 399/1339 (30%)
Cation_ATPase 538..634 CDD:289987 42/283 (15%)
HAD_like <875..906 CDD:304363 21/30 (70%)
PhoLip_ATPase_C 906..1160 CDD:292829 83/255 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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