DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp11b

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_083846.2	Gene:	Atp11b / 76295	MGIID:	1923545	Length:	1175	Species:	Mus musculus

Alignment Length:	1361	Identity:	475/1361 - (34%)
Similarity:	693/1361 - (50%)	Gaps:	309/1361 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LWNW----------HKGSRVSTI---NDWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQN 90
            :|.|          |: |...||   |.:.|..:..||...      .|||.|:|||:..|:|:|
Mouse     1 MWRWVRQQLGFDPPHQ-SDTRTIYIANRFPQNGLYTPQKFI------DNRIISSKYTIWNFVPKN 58

  Fly    91 LLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSP 155
            |.|||||:||||||::.::.|:||:|.||:||.|||.|||.|||.||||||.||:.:||.||.:|
Mouse    59 LFEQFRRVANFYFLIIFLVQLMIDTPTSPITSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP 123

  Fly   156 VTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKT-LM 219
            |.|:|.|.....:|:::..|:::.:.:|...|.|||||.|....|.|.:|||:||||:|||| :.
Mouse   124 VYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVS 188

  Fly   220 VPRD--LPTV-DLPEMHKLGIIECESPTTDLYSFNGK-IELKGGEGRVLPLSTENVLLRGSRVKN 280
            ||..  |.|| :|..:  :.:|||:.|..|||.|.|: |..:..|..|.||..|::||||:|:||
Mouse   189 VPETAVLQTVANLDSL--IAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKN 251

  Fly   281 TECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIA---IVTLLYFL----KR 338
            |:.:.|.||||||.:|:.||.:....|.::.|..:|.|||:.|:.||:   |.|:|.:.    ::
Mouse   252 TKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLIILISEAIISTILKYTWQAEEK 316

  Fly   339 YNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLEL 403
            ::|.:...|..:   ..:|..:.:|:.|:|:||:|:|::||||||||:|:|:.:||:|:.|||:|
Mouse   317 WDEPWYNQKTEH---QRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDL 378

  Fly   404 YENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDE---- 464
            |..|:||...||||:|||||||:..:|:|||||||:|||.|::|||||.|:.....:|..|
Mouse   379 YHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGLKYQEINGKLVPEGPSP 443

  Fly   465 -----ETKALLDINKFSANQR---------------------VFFQALSICHTVQVASGSLEQAD 503
                 |...|..::..|.:..                     :||:|:|:|||||:::
Mouse   444 DSTEGEVPFLGSLSHLSNSAHLTATSLRTSPESETELIKEHDLFFKAVSLCHTVQISN------- 501

  Fly   504 AGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVN 568

Mouse   502 ----------------------------------------------------------------- 501

  Fly   569 PLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISL 633
               |..||.|
Mouse   502 ---VQTDGIG------------------------------------------------------- 508

  Fly   634 QFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYA 698
                       ...|:                 ||                             .
Mouse   509 -----------DGPWQ-----------------PN-----------------------------L 516

  Fly   699 APTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRI 763
            ||.                         .|:|.||||||||||||.|..|:::.|..:||:.|::
Mouse   517 APA-------------------------QLEYYASSPDEKALVEAAARAGIIFVGISEETMEVKV 556

  Fly   764 VPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSA 828
            :            .|.|.::.||:|||.|||:||||||:...|:|.::.|||||.:.|.|....
Mouse   557 L------------GRLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGE- 608

  Fly   829 ELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNL 893
              :.||..|:.:||..|||||.||.|..:.:||:|....|.:|.::|::|::...:.:..||.:|
Mouse   609 --IAKTRIHVDEFALKGLRTLCIAYRQFTAKEYEDVDRRLFEARTALQHREEKLADAFQYIEKDL 671

  Fly   894 DLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKN 958
            .|||||||||.|||.|.:|:.:|:.||||:|||||||.|||::::|||||.........::..|:
Mouse   672 ILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKS 736

  Fly   959 REEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASSEFRDVAVKCTAVLCCRLSPLQKSE 1023
            .......|..|.|.|......:..|::||.||.:||.|....|.:|...|:||||||::||||::
Mouse   737 DSGCAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAK 801

  Fly  1024 VVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVH 1088
            |:.|||.|.|...|.::|||||||||||||||||||||:|||||||.:|:|.|:|..|.:||.||
Mouse   802 VIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVH 866

  Fly  1089 GHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISE 1153
            ||::.:|::.||.||||||:.|:...||:||:.|||..::|||::|||||:.:||||:|..::.|
Mouse   867 GHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPVLIYSLVE 931

  Fly  1154 KPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA 1218
            :......|...|.||:..:.|..|....||.|.:....|:.|.|:.::.....:..||..||...
Mouse   932 QHIDPHVLQSKPTLYRDISKNGLLSIKAFLYWTVLGFSHAFIFFFGSYFLVGKDTSLLGNGQMFG 996

  Fly  1219 FSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIII---SILGFVVTTVIYNVINLDY--DTDI 1278
            ...||||:...:|:.|.:|:.||:   .||.....::   ||:.:.:.::.|..|...:  ..::
Mouse   997 NWTFGTLVFTVMVITVTVKMALET---HFWTWINHLVTWGSIIFYFIFSLFYGGILWPFLGSQNM 1058

  Fly  1279 YWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMREKFES 1339
            |:.:..||:|...|..|::..|.||..|...::..|.|:       |....|.::.|...|
Mouse  1059 YFVFIQLLSSGSAWFAILLMVVTCLFIDVVKKVFDRQLH-------PTSTEKAQLAEAHSS 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	30/63 (48%)
		ATPase-Plipid	74..1317	CDD:273734	460/1289 (36%)
		E1-E2_ATPase	127..>345	CDD:278548	98/229 (43%)
		Cation_ATPase	<734..823	CDD:289987	40/88 (45%)
		HAD_like	<1036..1066	CDD:304363	24/29 (83%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	86/253 (34%)
Atp11b	NP_083846.2	PhoLip_ATPase_N	21..89	CDD:292826	34/73 (47%)
		ATPase-Plipid	39..1105	CDD:273734	463/1313 (35%)
		E1-E2_ATPase	96..>180	CDD:278548	40/83 (48%)
		Cation_ATPase	493..604	CDD:289987	58/334 (17%)
		HAD_like	628..867	CDD:304363	116/238 (49%)
		PhoLip_ATPase_C	846..1099	CDD:292829	87/262 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2701
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32919
Inparanoid	1	1.050	804	1.000	Inparanoid score	I495
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.940