DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp8a2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_038949921.1	Gene:	Atp8a2 / 691889	RGDID:	1594597	Length:	1200	Species:	Rattus norvegicus

Alignment Length:	1305	Identity:	417/1305 - (31%)
Similarity:	616/1305 - (47%)	Gaps:	298/1305 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQ 137
            |||.:.||:::||||:.|.||.||.||.:||.:.::..:.| ||....|:|:|||.::.:...|:
  Rat    71 NRISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLVIILTIAGIKE 135

  Fly   138 GYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKC 202
            ..||..|::.||.||.....|:|:|....|..::|..|:::.|.....:|.|:||..|::|.|.|
  Rat   136 IVEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVLNGQYLPADMVLFSSSEPQGMC 200

  Fly   203 FITTANLDGESNLKT---LMVPRDLPTVDLPEMHKL-GIIECESPTTDLYSFNGKIELKGGEGRV 263
            ::.|||||||:|||.   |....|:.|.::  :.|| |.||||.|...||.|.|.:.|.|...
  Rat   201 YVETANLDGETNLKIRQGLSHTADMQTREV--LMKLSGRIECEGPNRHLYDFTGTLHLDGKSS-- 261

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYIN-----RFLIVIL 323
            :.|..:.:||||::::||:.|.|..||||..:||..||.....|.::.|...|     .|.|:::
  Rat   262 VALGPDQILLRGTQLRNTQWVFGVVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLV 326

  Fly   324 VALIAIVTLLYFLKRY-NELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIE 387
            :||::.|..|::...: .:.:.|.|:....|        .|..:.|:|:||:|.||||||.||:|
  Rat   327 MALVSSVGALFWNGSHGGKSWYIKKMDTTSD--------NFGYNLLTFIILYNNLIPISLLVTLE 383

  Fly   388 LQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGN 452
            :.:...:.|:.||.::|..|.|.|.:..||||||||||:..||||||||||.|.|||::|||.|
  Rat   384 VVKYTQALFINWDTDMYYIENDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAG- 447

  Fly   453 KFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKS 517
                                                     |..|..
  Rat   448 -----------------------------------------VTYGHF------------------ 453

  Fly   518 GPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERR 582
              ||:            |.:||                                 |||
  Rat   454 --PEL------------AREQS---------------------------------SDD------- 464

  Fly   583 KRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQS 647
                       |.   ||.:..:...:.|  ||..:.| :|.
  Rat   465 -----------FC---RMTSCPSDSCDFN--DPRLLKN-IED----------------------- 489

  Fly   648 WEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRA 712
             |.|:                                              ||......|:|...
  Rat   490 -EHPT----------------------------------------------APCIQEFLTLLAVC 507

  Fly   713 ESQRRKNEIRDFIFTLDYQASSP------------DEKALVEACANLGMVYTGDDDETLRVRIVP 765
            .:...:.:..:.|    ||||||            ||.|||:....||.|:||
  Rat   508 HTVVPEKDGDEII----YQASSPGVNLCGVGSLLADEAALVKGAKKLGFVFTG------------ 556

  Fly   766 PHMDYKRPF-----AKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCAN 825
                 :.|:     |..:|:||..|:||||:|||||||||||...|:..:|.|||::.:|...:.
  Rat   557 -----RTPYSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRMPSGQLRLYCKGADNVIFERLSK 616

  Fly   826 SSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIE 890
            .| :.:.:|..|:..||..|||||.:|...:||.||:::|....:|:..|::|.|..||||..||
  Rat   617 DS-KYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASIILKDRAQRLEECYEIIE 680

  Fly   891 SNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIME 955
            .||.||||||:||.||..|.:|:.:|..|.||||||||||.|||:||..||..:..:.....:.|
  Rat   681 KNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKE 745

  Fly   956 CK---NREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALA-EASSEFRDVAVKCTAVLCCRL 1016
            ..   .|..:..|...|..  :.|...:.||:|||.:|..||: |....|.|:|:.|.||:|||:
  Rat   746 DSLDATRAAITQHCTDLGN--LLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRV 808

  Fly  1017 SPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCML 1081
            |||||||:|.::|...:.. |.:||||||||.|||.||||:||.|.||.||...:|:|.|:|..|
  Rat   809 SPLQKSEIVDVVKKRVKAI-TLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYL 872

  Fly  1082 KRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPI 1146
            ::||||||.:...|::..:||.||||:|...|...|.|...||...:::...:.|||||:|:||.
  Rat   873 EKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPP 937

  Fly  1147 LFIAISEKPYTEEKLMRTPQLYK--KNTD--NKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYN 1207
            ..:.|.|:..|:|.::|.|||||  :|.:  |.::.|.:    .:.|:.||:|:|:.......::
  Rat   938 FTLGIFERSCTQESMLRFPQLYKITQNAEGFNTKVFWGH----CINALVHSLILFWVPMKALEHD 998

  Fly  1208 NVLLNYGQTVAFSCFGTLLMWTVVVVVNLK------LWLESMYLSFWYIFTIIISILGFVVTTVI 1266
            ..|.: |....:...|.::...|||.|.||      .|.:..:|:.|  .:::|.::.|.|.:..
  Rat   999 TPLTS-GHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVW--GSMLIWLVFFGVYSTF 1060

  Fly  1267 YNVINLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIR---------MLQRALNIKSFS 1322
            :..|.:  ..|:......:|:|...||.:::...|||:.|...|         :|:....:::.|
  Rat  1061 WPTIPI--APDMKGQATMVLSSAHFWLGLLLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKS 1123

  Fly  1323 IFPGK 1327
            ...||
  Rat  1124 RVMGK 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	21/47 (45%)
		ATPase-Plipid	74..1317	CDD:273734	414/1293 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	77/227 (34%)
		Cation_ATPase	<734..823	CDD:289987	39/105 (37%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	77/267 (29%)
Atp8a2	XP_038949921.1	ATPase-Plipid	68..1118	CDD:273734	414/1293 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920