DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8b1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001025562.1	Gene:	atp8b1 / 594952	XenbaseID:	XB-GENE-490143	Length:	1250	Species:	Xenopus tropicalis

Alignment Length:	1358	Identity:	402/1358 - (29%)
Similarity:	617/1358 - (45%)	Gaps:	340/1358 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVF 128
            :||.:..| |.||:.||..|||||.||.|||:|.||.||||:.|:..:.. |.|:..|:|:||:.
Frog    85 LKKSKYAG-NAIKTYKYNPITFLPVNLYEQFKRAANAYFLVLLILQTIPQISTVTWSTTLIPLLL 148

  Fly   129 VIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLL 193
            |:.:||.|...:||.|::.||.:|:.|..||.||:....|.:.:..|::|.:.::..||.|::||
Frog   149 VLGITAIKDLVDDIARHKMDNEINNRPSEVITDGRFKKTKWKHIHVGDIIRINKNEFVPADVLLL 213

  Fly   194 RSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVD--LPEMHKL----GIIECESPTTDLYSFNG 252
            .|:||:..|::.||.||||:|||..|   .|...|  |.:..:|    |::|||.|...|..|.|
Frog   214 SSSDPNSLCYVETAELDGETNLKFKM---SLEITDKLLQKEEQLAGFDGLVECEEPNNRLDKFVG 275

  Fly   253 KIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR 317
            .:..:|..   ..|..:.:||||..|:|||...|..::.|..:|:..||..||.|....:..:|.
Frog   276 TLFWRGNS---FGLDADKILLRGCTVRNTEYCHGLVLFAGADTKIMRNSGKTRLKRTKIDYLMNY 337

  Fly   318 FLIVILVALIAIVTLLYFLKRYNELFVIPKL------TYLGDATD-SYSVKQFLQDYLSFLILFN 375
            .:..|.|.||.....|    ...:.|...||      .||.|..: |.|.:.||. :..::|:.|
Frog   338 MVYTIFVLLILAAAGL----AIGQTFWEAKLGAANVSWYLYDGNNYSPSYRGFLA-FWGYIIVLN 397

  Fly   376 YLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKN 440
            .::||||||::|:.|:..|:|:.|||::|.:..|.|....|:.|||:||||..:|||||||||:|
Frog   398 TMVPISLYVSVEVIRLGQSYFINWDLQMYFSPKDTPAKARTTTLNEQLGQIQYIFSDKTGTLTQN 462

  Fly   441 EMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAG 505
            .|.|::|:|||..:     ..:|:|.|                            ||..:|.|
Frog   463 IMTFKKCTINGTTY-----GDDDDELK----------------------------SGQTKQVD-- 492

  Fly   506 TAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPL 570
                             :|.:.:.                  |.|.:.|
Frog   493 -----------------FSWNPLA------------------DPSFTFH---------------- 506

  Fly   571 LVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQF 635
                |.|.:|:
Frog   507 ----DNYLIEQ------------------------------------------------------ 513

  Fly   636 RRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAP 700
            .|:..:||:.:.::..:                  |.:.|.|
Frog   514 IRAGKDKDVYEFFKLLA------------------LCHTVMA----------------------- 537

  Fly   701 TFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVP 765
                          ::...|       |.|||:||||.|||.|..|.|.|:......|:.:..:
Frog   538 --------------EKTDGE-------LIYQAASPDEGALVTAARNFGFVFLSRTQSTITISEL- 580

  Fly   766 PHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAEL 830
                       .:|:|::.|.:|:|.|||||||:|||..||:..:|.|||::.::.. .:....:
Frog   581 -----------GQEKTYEVLAILDFNSDRKRMSIIVRQPDGRIRLYCKGADTVIYER-LHPDNPI 633

  Fly   831 VTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDL 895
            ..:|...:..||...||||.:..:.|::.:::::..:..||:.:..||.:..:..|..||::|.|
Frog   634 KDQTQKALDIFANASLRTLCLCYKDINKGDFENWSKKYKQASVATSNRDEALDRVYEAIETDLKL 698

  Fly   896 LGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNRE 960
            |||||:||.|||||:.|:.:|..|.||||||||||.|||.||..||..:..|.      |....|
Frog   699 LGATAIEDKLQDDVSGTIFNLARADIKIWVLTGDKKETAENIGYSCKLLDDDT------EILYGE 757

  Fly   961 EMLLHLNAL---DREIIFG--------------IGQECALLIDGKSLGVALAEASS--------- 999
            ::.:||...   .|..:.|              ..::.||:|.|..|...|.|...
Frog   758 DINVHLQTRMENQRNQMSGNQGAQSNQSGAFLPTDKKHALIITGSWLNEILLEKKKRKKKRLKLK 822

  Fly  1000 ---------------------------EFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNT 1037
                                       .|.|:|.:|:||:|||::|.||:.||.|:|...:.. |
Frog   823 FPRTKEEKEQQLHEKLKAYALKEQRQRSFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAV-T 886

  Fly  1038 ASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLY 1102
            .:||||||||:||:.||:|:||.|:||.||...:|::||:|..|:|||||||.:..:|:...:.|
Frog   887 LAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRY 951

  Fly  1103 FFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQL 1167
            |||||..|..:.|.:.|...||:.:||:..|:|||||:|:|||:|.:.:.::..:::..:..|:|
Frog   952 FFYKNFSFTLVHFWYSFFNGFSAQTVYEDWFITLYNVLYSSLPVLLVGLLDQDVSDKLSLAFPRL 1016

  Fly  1168 YKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQ----TVAFSCFGTLLMW 1228
            |.....:...::..|.:.:...|..|:|||     |..|...||..||    ...:..|......
Frog  1017 YVPGQKDLLFNYKKFFLSLFHGIVTSLIIF-----FIPYGAFLLTMGQDGEAPSDYQSFAVTTAT 1076

  Fly  1229 TVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLD-YDTDIY----------WAY 1282
            .:|:.||.::.|::.|.:|...|:|..||       .||..|..| :...|:          .|.
Frog  1077 ALVITVNFQIGLDTSYWTFVNAFSIFGSI-------AIYFGIMFDLHSAGIHVLFPSMFIFTGAA 1134

  Fly  1283 NNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKL-KMREKFES 1339
            .|.|....:||.||:|...||:|...:|.|.:       :|:|.:..|: |..:||::
Frog  1135 PNALRQPYLWLTIILTVAFCLLPIVALRFLAK-------TIWPSESDKIQKKGKKFKA 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	28/56 (50%)
		ATPase-Plipid	74..1317	CDD:273734	393/1324 (30%)
		E1-E2_ATPase	127..>345	CDD:278548	74/223 (33%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	19/29 (66%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	81/263 (31%)
atp8b1	NP_001025562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
atp8b1	NP_001025562.1	P-type_ATPase_APLT_Dnf-like	92..1049	CDD:319770	360/1199 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920