DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP8B2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001354863.1	Gene:	ATP8B2 / 57198	HGNCID:	13534	Length:	1209	Species:	Homo sapiens

Alignment Length:	1333	Identity:	405/1333 - (30%)
Similarity:	632/1333 - (47%)	Gaps:	294/1333 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 WNWHKGS------RVSTINDWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRI 98
            |:..|.|      |.:..||         ::..:|.....|.||::||.::||||.||.|||:.:
Human    20 WSRKKPSWGTEEERRARAND---------REYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEV 75

  Fly    99 ANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDG 162
            ||.|||.:.|:.|:.. |.:|..|:::|||.|:.:||.|...:|..|:::||.||:....|:.:|
Human    76 ANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLING 140

  Fly   163 KEAIIKSQ---DVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDL 224
               |::.:   :|..|::|.:|.:..|..||:||.|::|||.|:|.||.||||:|:|   |.:.:
Human   141 ---ILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMK---VRQAI 199

  Fly   225 P-TVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECV 284
            | |.:|.::.||    |.:.||.|...|..|:|.:..|..:   .|||.:|:||||..::|||..
Human   200 PVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKENK---FPLSNQNMLLRGCVLRNTEWC 261

  Fly   285 IGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKL- 348
            .|..::.|..:||..||..|:.|..|.:..:|..::.|...|:.:..:|.......|..|..:.
Human   262 FGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGMRFQ 326

  Fly   349 TYL--GDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQP 411
            .||  .:|.||.....|| .:.|::|:.|.::||||||::|:.|:..|:|:.||.:::..:...|
Human   327 VYLPWDEAVDSAFFSGFL-SFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTP 390

  Fly   412 CVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFS 476
            ....|:.|||||||:..:|||||||||:|.|.|.:|||||:.:
Human   391 AEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSY---------------------- 433

  Fly   477 ANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSEL 541

Human   434 ----------------------------------------------------------------- 433

  Fly   542 NVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAAS 606
                                   .||..:|    |:..|..:||
Human   434 -----------------------GDVFDVL----GHKAELGERP--------------------- 450

  Fly   607 DLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYL 671
                                  .|:...|.....:|.|  .|: ||                  |
Human   451 ----------------------EPVDFSFNPLADKKFL--FWD-PS------------------L 472

  Fly   672 TNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPD 736
            ...|....|.....||..|                  |........|||     ..|.|:|.|||
Human   473 LEAVKIGDPHTHEFFRLLS------------------LCHTVMSEEKNE-----GELYYKAQSPD 514

  Fly   737 EKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIV 801
            |.|||.|..|.|.|:.....:|:.|..:...:            |:|.|.:|:|.:.||||||||
Human   515 EGALVTAARNFGFVFRSRTPKTITVHEMGTAI------------TYQLLAILDFNNIRKRMSVIV 567

  Fly   802 RDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLV 866
            |:.:||..:|.|||::.:.....:|:.||:..|..|::::|..|||||.:|.:.:.||.|:::..
Human   568 RNPEGKIRLYCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAE 632

  Fly   867 ELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKV 931
            ...||:.:.::|:......|.::|:|:.||||||:||.||..|.:|:..|..|.||||||||||.
Human   633 RRLQASLAQDSREDRLASIYEEVENNMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQ 697

  Fly   932 ETALNIALSCGHIPPDAKKYFIME-----------CKNREEMLLHLNALDR-------------- 971
            |||:||..||..:..|..:.||:.           .|.||:|:....::..
Human   698 ETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLT 762

  Fly   972 EIIFGIGQECALLIDGKSLGVAL-AEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENY 1035
            .::..:..|.||:|:|.||..|| |:...||.:.|..|.||:|||::||||::||.|:|...:..
Human   763 SVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAV 827

  Fly  1036 NTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLV 1100
             |.:|||||||||||:.||:|:||.|:||.||...:|::|::|..|:|||||||.:..:|:...:
Human   828 -TLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFL 891

  Fly  1101 LYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTP 1165
            .||||||..|..:.|.|.|...||:.:|||..|:||||::|||||:|.:.:.::...|::.|..|
Human   892 CYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYP 956

  Fly  1166 QLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA-FSCFGTLLMWT 1229
            :||:....|...:...|.:.:...||.||::|:..:..|  .:...:.|..:| :..|...:..:
Human   957 KLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVF--ADATRDDGTQLADYQSFAVTVATS 1019

  Fly  1230 VVVVVNLKLWLESMYLS------FWYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAYN--NLL 1286
            :|:||::::.|::.|.:      .|....:..:||..:.:..::::    :.....:..|  |.|
Human  1020 LVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDM----FPNQFRFVGNAQNTL 1080

  Fly  1287 ASLPVWLWIIVTCVACLVPDYTIRMLQRALNIK 1319
            |...|||.|::|.|.|::|....|.|:  ||:|
Human  1081 AQPTVWLTIVLTTVVCIMPVVAFRFLR--LNLK 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	24/64 (38%)
		ATPase-Plipid	74..1317	CDD:273734	395/1289 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	76/225 (34%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/257 (30%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		4/15 (27%)
ATP8B2	NP_001354863.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1181..1209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144911
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750