DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp9b

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_005170114.1	Gene:	atp9b / 568160	ZFINID:	ZDB-GENE-060503-583	Length:	1136	Species:	Danio rerio

Alignment Length:	1293	Identity:	362/1293 - (27%)
Similarity:	563/1293 - (43%)	Gaps:	290/1293 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 WLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVS 118
            ||    |.|:..::|.||  |.||:.||.::||:|..|.:||:...|.||||:.....:....:.
Zfish   106 WL----GHPEKCEEKYPK--NAIKNQKYNIVTFVPGVLYQQFKFFLNLYFLVVACSQFVPSLKIG 164

  Fly   119 PM-TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNS---SPVTVIRDGKEAIIKSQDVIPGELIV 179
            .: |...||.||:|||..::..:::.|.|.|..:||   |.:||  .|| ..:||.|:..|:||:
Zfish   165 YLYTYWAPLGFVLAVTMVREAVDEVRRCRRDKEMNSQLYSKLTV--RGK-VQVKSSDIQVGDLII 226

  Fly   180 VERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKT---LMVPRDLPTV-DLPEMHKLGIIEC 240
            ||::..:|.|::.||:::..|.|||.|..||||::.|.   :...:.||.: ||..:.  ..:..
Zfish   227 VEKNQRIPADMIFLRTSEKTGSCFIRTDQLDGETDWKLRIGVACTQRLPALGDLFSIS--AYVYV 289

  Fly   241 ESPTTDLYSFNGKIELKGGEGRV-LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLT 304
            :.|..|::||.|....:..:..: ..||.||.|. .|.|..:..|||..:|||...:..:|:..:
Zfish   290 QKPQLDIHSFEGNFTREDCDPPIHESLSIENTLW-ASTVVASGTVIGVVIYTGKEMRSVMNTSQS 353

  Fly   305 RNKNASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLS 369
            :||....:..:||....:.:|.:.:..::..|:           .:||         .:.::...
Zfish   354 KNKVGLLDLELNRLTKALFLAQVVLSVVMVALQ-----------GFLG---------PWFRNLFR 398

  Fly   370 FLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKT 434
            |::||:|:|||||.|.:::.:....|.      :.::|.....||.||.:.||||::..|.:|||
Zfish   399 FVVLFSYIIPISLRVNLDMGKSAYGWM------IMKDENIPGTVVRTSTIPEELGRLVYLLTDKT 457

  Fly   435 GTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSL 499
            ||||:|||.|::..:....:   .|...||                  .|:..|....||:|.
Zfish   458 GTLTQNEMVFKRLHLGTVSY---GTDTMDE------------------IQSHIIQSYAQVSSA-- 499

  Fly   500 EQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIIS 564
             |::..:|...|  :.|..||.......::...|.|                      |.:..:.
Zfish   500 -QSNGSSASSTP--SRKPQPPAPKVRKSVSSRIHEA----------------------VKAIALC 539

  Fly   565 SDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFR 629
            .:|.|:..|                         |:|...|                 ||
Zfish   540 HNVTPVYES-------------------------RVNGANA-----------------EP----- 557

  Fly   630 PISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR 694
                            :|.||....:..:|
Zfish   558 ----------------ESTEADQDFSDDNR----------------------------------- 571

  Fly   695 ESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL 759
                                              .||||||||.|||....::|:.....|..:|
Zfish   572 ----------------------------------TYQASSPDEVALVRWTESVGLTLVNRDLTSL 602

  Fly   760 RVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVR-DTDGKKWIYTKGAESYVFPLC 823
            ::         |.|..:..  |:..|.:..|||:.|||.:||| :..|....|.|||:.
Zfish   603 QL---------KTPAGQIL--TYYILQIFPFTSESKRMGIIVREEATGDITFYMKGADV------ 650

  Fly   824 ANSSAELVTKTD---AHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEEC 885
              :.|.:|...|   ....:.||.|||||.:|::.::||:||||.....||..|:.:|.......
Zfish   651 --AMASIVQYNDWLEEECGNMAREGLRTLVVAKKSLTEEQYQDFENRYNQAKLSIHDRNLKVAAV 713

  Fly   886 YAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKK 950
            ...:|..::||..|.|||.||.||..||..|:.||||||:|||||:|||..||.|...:..:...
Zfish   714 VESLEREMELLCLTGVEDQLQADVRPTLELLRNAGIKIWMLTGDKLETATCIAKSSHLVSRNQDI 778

  Fly   951 YFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASSEFRDVAVKCTAVLCCR 1015
            :......||.|..|.|||..|:      .:|||:|.|.||.|.|.....||.::|.:|.||:|||
Zfish   779 HVFKPVSNRGEAHLELNAFRRK------HDCALVISGDSLEVCLRYYEHEFVELACQCPAVVCCR 837

  Fly  1016 LSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCM 1080
            .||.||:::|.|::....| .|.:||||.|||||||.|..||||.|:||:||:..|||:..:|..
Zfish   838 CSPTQKAQIVRLLQQHTAN-RTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFKH 901

  Fly  1081 LKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLP 1145
            :.|||:|||.....|.:.|..:..::.::...:..:|.....|:|..:|....:..|..|||..|
Zfish   902 IGRLLMVHGRNSYKRSAALGQFVMHRGMIISTMQAVFSSIFYFASVPLYQGFLMVGYATIYTMFP 966

  Fly  1146 ILFIAISE--KPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNN 1208
            :..:.:.:  ||   |..:..|:|||..|..:.|.:..||:|||.:||...|:.|.|...|....
Zfish   967 VFSLVLDQDVKP---EMALLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMYGALVLFDQEF 1028

  Fly  1209 VLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFW-YIFTIIISILGFVVTTVIYNV--- 1269
            |     ..||.|....:|...::|.:.::.|       .| .:...:||:..::.:....|.
Zfish  1029 V-----HVVAISFTALILTELLMVALTIRTW-------HWLMVVAQLISLACYLASLAFLNEYFG 1081

  Fly  1270 ---INLDYDTDIYWAYNNLLASLPVWLW--IIVTCVACLVPDYTIRMLQRALNIKSFS 1322
               :.|....|:.:      .:..|:||  .::|.|:|| |.|.|:.|:|..:..|:|
Zfish  1082 IGRVTLGAFLDLSF------ITTRVFLWKVCVITLVSCL-PLYIIKYLKRKFSPPSYS 1132

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	21/64 (33%)
		ATPase-Plipid	74..1317	CDD:273734	353/1266 (28%)
		E1-E2_ATPase	127..>345	CDD:278548	66/225 (29%)
		Cation_ATPase	<734..823	CDD:289987	28/89 (31%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	66/259 (25%)
atp9b	XP_005170114.1	PhoLip_ATPase_N	104..168	CDD:292826	23/67 (34%)
		ATPase-Plipid	117..1134	CDD:273734	357/1278 (28%)
		E1-E2_ATPase	173..413	CDD:278548	78/265 (29%)
		Cation_ATPase	567..649	CDD:289987	32/161 (20%)
		HAD_like	730..880	CDD:119389	74/156 (47%)
		PhoLip_ATPase_C	889..1128	CDD:292829	66/260 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010