DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8b4

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_687715.4	Gene:	atp8b4 / 559291	ZFINID:	ZDB-GENE-121116-7	Length:	1214	Species:	Danio rerio

Alignment Length:	1331	Identity:	398/1331 - (29%)
Similarity:	621/1331 - (46%)	Gaps:	302/1331 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPL 126
            :|..::.....||||:.||.:.||||.||.|||:|.||.||||:.|:.|:.: |.:|..|:::||
Zfish    40 RDYNERFSYADNRIKTAKYNVFTFLPINLFEQFQRFANAYFLVLLILQLIPEISSLSWFTTIVPL 104

  Fly   127 VFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLV 191
            |.|:|:||.|...:|..|:::|..||:....|:..||....|..:|..|::|.:|.:..|..||:
Zfish   105 VLVLAITAVKDATDDYFRHKSDQQVNTRQSQVLIKGKLQNEKWMNVRVGDVIKLENNQFVAADLL 169

  Fly   192 LLRSTDPHGKCFITTANLDGESNLK---TLMVPRDLPTVDLPEMHKL----GIIECESPTTDLYS 249
            ||.|::|:|.|:|.||.||||:|||   .|.|..||.    .::.||    |.:.||.|...|..
Zfish   170 LLSSSEPYGLCYIETAELDGETNLKVRQALTVTSDLG----DDVAKLADFNGEVICEPPNNKLDK 230

  Fly   250 FNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETY 314
            |.|.:..|..:   .||..|.:||||..::|||...|..::.|:.:||..|...|:.|..|.:..
Zfish   231 FIGTLYWKDNK---YPLDNEKMLLRGCVLRNTEWCFGLVIFAGLQTKLMQNCGRTKFKRTSIDKL 292

  Fly   315 INRFLIVILVALIAIVTLL---------------YFLKRYNELFVIPKLTYLGDATDSYSVKQFL 364
            :|..::.|...||.:..:|               :...::.||.|  ...:.|..|
Zfish   293 MNTLVLWIFGFLICMGIILAIGNTIWEQSVGSDFWAYLQWKELTV--NAVFSGFLT--------- 346

  Fly   365 QDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINIL 429
              :.|::|:.|.::||||||::|:.|:..|:|:.||..:|.:..|.|....|:.|||||||:..:
Zfish   347 --FWSYIIILNTVVPISLYVSVEVLRLGHSYFINWDRRMYYSRKDTPAEARTTTLNEELGQVEFI 409

  Fly   430 FSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQV 494
            |||||||||:|.|.|.:|||||..:
Zfish   410 FSDKTGTLTQNIMVFNKCSINGKTY---------------------------------------- 434

  Fly   495 ASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVN 559
                                           .|:.:|           .||.:|.:       ..
Zfish   435 -------------------------------GDVFDE-----------FGHKVDIT-------EK 450

  Fly   560 STIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEP 624
            :..:....|||:        :|:.|
Zfish   451 TPCVDFSFNPLM--------DRKFR---------------------------------------- 467

  Fly   625 TTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSP 689
                      |..|:                               |...:....|.....||
Zfish   468 ----------FHDSS-------------------------------LVEAIKLEEPLVQEFFR-- 489

  Fly   690 STTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGD 754
                   ..|...|..|       .:|.:.|       |.|||.||||.|||.|..|.|.|:...
Zfish   490 -------LLALCHTVMP-------EERNEGE-------LVYQAQSPDEGALVTAARNFGFVFRSR 533

  Fly   755 DDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYV 819
            ..||:.:            :...:..|:|.|.:|:|.:.|||||||||:..|:..:|:|||::.:
Zfish   534 TPETITL------------YEMGQAVTYQLLAILDFNNVRKRMSVIVRNPKGQLKLYSKGADTIL 586

  Fly   820 FPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEE 884
            |.....|:.||:..|..|:::||..||||||:|.:.:.|:.:.::..:|..|:::|:||::....
Zfish   587 FDRLDPSNEELMFTTSEHLNEFAGEGLRTLALAYKDLDEDVFDEWTKKLLFASTALDNREEKLGA 651

  Fly   885 CYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAK 949
            .|.:||..:.||||||:||.||:.|.:|:..|..|.||||||||||:|||:||..||..:..|..
Zfish   652 LYEEIEQGMMLLGATAIEDKLQEGVPETIACLTLANIKIWVLTGDKLETAMNIGYSCNMLRDDMN 716

  Fly   950 KYFIM----------ECKNREEMLL----------------HLNALDREIIFGIGQECALLIDGK 988
            :.||:          |.:..:|.::                .|.::|......|..|.||:|:|.
Zfish   717 EVFIISGHTMLEVQQELRTAKERIMGPSKDKFSSGLDMEKTELYSVDSVFEETIIAEYALIINGH 781

  Fly   989 SLGVAL-AEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQE 1052
            ||..|| ||......|||..|.:|:|||::||||:.||.||| .::...|.:|||||||||||:.
Zfish   782 SLAHALEAELEQILVDVACLCKSVICCRVTPLQKALVVELIK-RHKRAVTLAIGDGANDVSMIKT 845

  Fly  1053 AHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLF 1117
            ||:|:||.|:||.||...:|::||:|..|:|||||||.:...|:...:.||||||..|..:.|.:
Zfish   846 AHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYHRMCNFLCYFFYKNFAFTLVHFWY 910

  Fly  1118 QFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYF 1182
            .|...||:.:|||..|:||:|::|||||:|.:.:.::...|:..:|.|.||:....|:..:...|
Zfish   911 GFLCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNEQYSLRYPNLYRPGQLNQLFNKRKF 975

  Fly  1183 LMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA-FSCFGTLLMWTVVVVVNLKLWLESMYLS 1246
            ....|..:|.|.|:|:..:..|.  ..:.:.|..:: ...|...:..::|:||::::.|::.|.:
Zfish   976 FTCTLQGVYTSFILFFIPYGAFM--PAVRDDGAQISDQQAFAVTIATSLVIVVSVQIGLDTNYWT 1038

  Fly  1247 ------FWYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVP 1305
                  .|....:..:||..:.:..|:.:....:.. |..|.|:|...: |||.|::..|.|::|
Zfish  1039 AVNHFFIWGSLAVYFAILFAMNSNGIFTIFPNQFPF-IGSARNSLNQKI-VWLVILLNTVVCIMP 1101

  Fly  1306 DYTIRMLQRALNIKSFSIFPGKQRKLKMREK 1336
            ...:|.::.       .::|....|:::.::
Zfish  1102 MLAVRFIKT-------DLYPTHTDKVRLLQQ 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	27/58 (47%)
		ATPase-Plipid	74..1317	CDD:273734	395/1299 (30%)
		E1-E2_ATPase	127..>345	CDD:278548	77/239 (32%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	73/255 (29%)
atp8b4	XP_687715.4	PhoLip_ATPase_N	34..99	CDD:292826	27/58 (47%)
		ATPase-Plipid	48..1121	CDD:273734	397/1317 (30%)
		Cation_ATPase	493..591	CDD:289987	41/123 (33%)
		HAD_like	<830..861	CDD:304363	21/30 (70%)
		PhoLip_ATPase_C	861..1115	CDD:292829	73/264 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820