DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp8b1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001001488.2	Gene:	Atp8b1 / 54670	MGIID:	1859665	Length:	1251	Species:	Mus musculus

Alignment Length:	1370	Identity:	391/1370 - (28%)
Similarity:	598/1370 - (43%)	Gaps:	374/1370 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVI 130
            |:.....|.||:.||...||||.||.|||:|.||||||::.|:..:.. |.::..|:|:||:.|:
Mouse    88 KESKYASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVL 152

  Fly   131 AVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRS 195
            .:||.|...:|:.|::.|..:|:....||:||:..|||.:|:..|::|.::::..:|.|::||.|
Mouse   153 GITAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSS 217

  Fly   196 TDPHGKCFITTANLDGESNLK----------TLMVPRDLPTVDLPEMHKLGIIECESPTTDLYSF 250
            ::|:..|::.||.||||:|||          .|.:..:|.|.|       |.||||.|...|..|
Mouse   218 SEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFD-------GFIECEEPNNRLDKF 275

  Fly   251 NGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYI 315
            .|.:..|   .:..||..:.:||||..::||:...|..::.|..:|:..||..||.|....:..:
Mouse   276 TGTLFWK---NQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLM 337

  Fly   316 NRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGD---ATDSYSVKQFLQDYLSFLILFNYL 377
            |..:..|.:.||.:...|.....|.|..|.....||.|   ||.||  :.|| ::..::|:.|.:
Mouse   338 NYMVYTIFIVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSY--RGFL-NFWGYIIVLNTM 399

  Fly   378 IPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEM 442
            :||||||::|:.|:..|.|:.|||::|..|.|.|....|:.|||:||||:.:|||||||||:|.|
Mouse   400 VPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIM 464

  Fly   443 NFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTA 507
            .|::|.|||.
Mouse   465 TFKKCCINGT------------------------------------------------------- 474

  Fly   508 KREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLV 572
                                |..:..:|||.|...: ..:|.|.:...:|            .|.
Mouse   475 --------------------IYGDHRDASQHSHSKI-ELVDFSWNTFADG------------KLA 506

  Fly   573 SDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRR 637
            ..|.|.:|:                                    :.:|.||
Mouse   507 FYDHYLIEQ------------------------------------IQSGKEP------------- 522

  Fly   638 STSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTF 702

Mouse   523 ----------------------------------------------------------------- 522

  Fly   703 TRQPTILVRAESQRRKNEIRDFIFTL---------------DYQASSPDEKALVEACANLGMVYT 752
                             |:|.|.|.|               :|||:||||.|||.|..|.|..:.
Mouse   523 -----------------EVRQFFFLLSICHTVMVDRIDGQINYQAASPDEGALVNAARNFGFAFL 570

  Fly   753 GDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAES 817
            .....|:.|..:            ..|.|:..|.:|:|.|||||||:|||..:|...:|.|||::
Mouse   571 ARTQNTITVSEL------------GSERTYNVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADT 623

  Fly   818 YVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLS 882
            .::......:.......|| :..||...||||.:..:.|.|:|:.::..:...|:.:..||.:..
Mouse   624 VIYERLHRMNPTKQETQDA-LDIFASETLRTLCLCYKEIEEKEFTEWNNKFMAASVASSNRDEAL 687

  Fly   883 EECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPD 947
            ::.|.:||.:|.||||||:||.|||.|.:|:..|..|.||||||||||.|||.||..:|..:..|
Mouse   688 DKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTED 752

  Fly   948 AKKYFIMECKNRE-EMLLHL---NALDR------------EIIFGIGQECALLIDGKSLGVALAE 996
            .     ..|...: ..|||.   |..:|            |..|..|:..||:|.|..|...|.|
Mouse   753 T-----TICYGEDINSLLHTRMENQRNRGGVSAKFAPPVYEPFFPPGENRALIITGSWLNEILLE 812

  Fly   997 ASSE------------------------------------FRDVAVKCTAVLCCRLSPLQKSEVV 1025
            ..::                                    |.|:|.:|:||:|||::|.||:.||
Mouse   813 KKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLACECSAVICCRVTPKQKAMVV 877

  Fly  1026 SLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGH 1090
            .|:|...:.. |.:||||||||:||:.||:|:||.|:||.||...:|::||:|..|:|||||||.
Mouse   878 DLVKRYKKAI-TLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGR 941

  Fly  1091 YHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKP 1155
            :..:|:...:.||||||..|..:.|.:.|...:|:.:.|:..|:|||||:|:|||:|.:.:.::.
Mouse   942 WSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQD 1006

  Fly  1156 YTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA-- 1218
            .:::..:|.|.||.....:...::..|.:.:|..:..|:::|:..         |..|.|||.
Mouse  1007 VSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMVLFFIP---------LGAYLQTVGQD 1062

  Fly  1219 ------FSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDY-DT 1276
                  :..|...:...:|:.||.::.|::.|.:|...|:|..||       .:|..|..|: ..
Mouse  1063 GEAPSDYQSFAVTVASALVITVNFQIGLDTSYWTFVNAFSIFGSI-------ALYFGIMFDFHSA 1120

  Fly  1277 DIYWAY----------NNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKL 1331
            .|:..:          :|.|....:||.||:|...||:|...||.|       |.:|:|.:..|:
Mouse  1121 GIHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFL-------SMTIWPSESDKI 1178

  Fly  1332 KMREK 1336
            :...|
Mouse  1179 QKHRK 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	24/54 (44%)
		ATPase-Plipid	74..1317	CDD:273734	385/1342 (29%)
		E1-E2_ATPase	127..>345	CDD:278548	71/227 (31%)
		Cation_ATPase	<734..823	CDD:289987	32/88 (36%)
		HAD_like	<1036..1066	CDD:304363	19/29 (66%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/267 (28%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PhoLip_ATPase_N	86..142	CDD:292826	24/53 (45%)
		ATPase-Plipid	92..1179	CDD:273734	389/1360 (29%)
		E1-E2_ATPase	171..>234	CDD:278548	22/62 (35%)
		Cation_ATPase	534..628	CDD:289987	35/105 (33%)
		HAD_like	<875..919	CDD:304363	24/44 (55%)
		PhoLip_ATPase_C	919..1173	CDD:292829	78/276 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750