DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP8B1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001361314.1	Gene:	ATP8B1 / 5205	HGNCID:	3706	Length:	1251	Species:	Homo sapiens

Alignment Length:	1368	Identity:	387/1368 - (28%)
Similarity:	595/1368 - (43%)	Gaps:	370/1368 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 KKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVI 130
            |:.....|.||:.||...||:|.||.|||:|.||.|||.:.|:..:.. |.::..|:|:||:.|:
Human    88 KESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVVL 152

  Fly   131 AVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRS 195
            .|||.|...:|:.|::.|..:|:....||:||:..:.|.:::..|::|.::::..||.|::||.|
Human   153 GVTAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILLLSS 217

  Fly   196 TDPHGKCFITTANLDGESNLKTLM--------VPRD--LPTVDLPEMHKLGIIECESPTTDLYSF 250
            ::|:..|::.||.||||:|||..|        :.|:  |.|.|       |.||||.|...|..|
Human   218 SEPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFD-------GFIECEEPNNRLDKF 275

  Fly   251 NGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYI 315
            .|.:..:...   .||..:.:||||..::||:...|..::.|..:|:..||..||.|....:..:
Human   276 TGTLFWRNTS---FPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLM 337

  Fly   316 NRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDA-TDSYSVKQFLQDYLSFLILFNYLIP 379
            |..:..|.|.||.:...|.....|.|..|.....||.|. .|:.|.:.|| .:..::|:.|.::|
Human   338 NYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYRGFL-IFWGYIIVLNTMVP 401

  Fly   380 ISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNF 444
            |||||::|:.|:..|.|:.|||::|..|.|.|....|:.|||:||||:.:|||||||||:|.|.|
Human   402 ISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTF 466

  Fly   445 QQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKR 509
            ::|.|||..:                      .:.|
Human   467 KKCCINGQIY----------------------GDHR----------------------------- 480

  Fly   510 EPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSD 574
                             |.::.:||..:|        :|.|.:.:.:|            .|...
Human   481 -----------------DASQHNHNKIEQ--------VDFSWNTYADG------------KLAFY 508

  Fly   575 DGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRST 639
            |.|.:|:                                    :.:|.||
Human   509 DHYLIEQ------------------------------------IQSGKEP--------------- 522

  Fly   640 SEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTR 704

Human   523 ----------------------------------------------------------------- 522

  Fly   705 QPTILVRAESQRRKNEIRDFIF---------------TLDYQASSPDEKALVEACANLGMVYTGD 754
                           |:|.|.|               .|:|||:||||.|||.|..|.|..:...
Human   523 ---------------EVRQFFFLLAVCHTVMVDRTDGQLNYQAASPDEGALVNAARNFGFAFLAR 572

  Fly   755 DDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYV 819
            ...|:.:..:            ..|.|:..|.:|:|.|||||||:|||..:|...:|.|||::.:
Human   573 TQNTITISEL------------GTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGADTVI 625

  Fly   820 FPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEE 884
            :......:.......|| :..||...||||.:..:.|.|:|:.::..:...|:.:..||.:..::
Human   626 YERLHRMNPTKQETQDA-LDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTNRDEALDK 689

  Fly   885 CYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAK 949
            .|.:||.:|.||||||:||.|||.|.:|:..|..|.||||||||||.|||.||..:|..:..|.
Human   690 VYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTEDT- 753

  Fly   950 KYFIMECKNRE-EMLLHL---NALDR------------EIIFGIGQECALLIDGKSLGVALAEAS 998
                ..|...: ..|||.   |..:|            |..|..|...||:|.|..|...|.|..
Human   754 ----TICYGEDINSLLHARMENQRNRGGVYAKFAPPVQESFFPPGGNRALIITGSWLNEILLEKK 814

  Fly   999 SE------------------------------------FRDVAVKCTAVLCCRLSPLQKSEVVSL 1027
            ::                                    |.|:|.:|:||:|||::|.||:.||.|
Human   815 TKRNKILKLKFPRTEEERRMRTQSKRRLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDL 879

  Fly  1028 IKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYH 1092
            :|...:.. |.:||||||||:||:.||:|:||.|:||.||...:|::||:|..|:|||||||.:.
Human   880 VKRYKKAI-TLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWS 943

  Fly  1093 SVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYT 1157
            .:|:...:.||||||..|..:.|.:.|...:|:.:.|:..|:|||||:|||||:|.:.:.::..:
Human   944 YIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVS 1008

  Fly  1158 EEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA---- 1218
            ::..:|.|.||.....:...::..|.:.:|..:..|:|:|:..         |..|.|||.
Human  1009 DKLSLRFPGLYIVGQRDLLFNYKRFFVSLLHGVLTSMILFFIP---------LGAYLQTVGQDGE 1064

  Fly  1219 ----FSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDY-DTDI 1278
                :..|...:...:|:.||.::.|::.|.:|...|:|..||       .:|..|..|: ...|
Human  1065 APSDYQSFAVTIASALVITVNFQIGLDTSYWTFVNAFSIFGSI-------ALYFGIMFDFHSAGI 1122

  Fly  1279 YWAY----------NNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKM 1333
            :..:          :|.|....:||.||:....||:|...||.|       |.:|:|.:..|::.
Human  1123 HVLFPSAFQFTGTASNALRQPYIWLTIILAVAVCLLPVVAIRFL-------SMTIWPSESDKIQK 1180

  Fly  1334 REK 1336
            ..|
Human  1181 HRK 1183

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	22/54 (41%)
		ATPase-Plipid	74..1317	CDD:273734	381/1340 (28%)
		E1-E2_ATPase	127..>345	CDD:278548	71/227 (31%)
		Cation_ATPase	<734..823	CDD:289987	31/88 (35%)
		HAD_like	<1036..1066	CDD:304363	19/29 (66%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	77/267 (29%)
ATP8B1	NP_001361314.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
ATP8B1	NP_001361314.1	P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	349/1205 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144913
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850