Protein Alignment CG4301 and Atp11a

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_056619.1
• Gene: Atp11a / 50770
• MGIID: 1354735
• Length: 1187
• Species: Mus musculus
• Alignment Length: 1344
• Identity: 447/1344 - (33%)
• Similarity: 663/1344 - (49%)
• Gaps: 339/1344 - (25%)

  Fly    53 DWLQ---IQIGGPQDIKKKRPKG----------QNRIKSTKYTLITFLPQNLLEQFRRIANFYFL 104
            :|:.   |.:|     .|:.|.|          .|||.|:|||...|:|:||.||||||||||||
Mouse    19 NWVDSRTIYVG-----HKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFL 78

  Fly   105 VMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKS 169
            ::.::.|:||:|.||:||.|||.|||.|||.||||||.||::.||.:|..||..|:.||....:|
Mouse    79 IIFLVQLIIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQS 143

  Fly   170 QDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDL----PTVDLP 230
            :.:..|::::|:.|...||||:.|.|....|.|.:|||:|||||:.||....:|.    ...|:.
Mouse   144 RKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTKGFHTEADVD 208

  Fly   231 EMHKLGIIECESPTTDLYSFNGKIELKG--GEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGM 293
            .:|  ..||||.|..|||.|.|:|.:..  .:..|.||.:||:||||:.:||||.:.|.|:||||
Mouse   209 SLH--ATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGM 271

  Fly   294 ISKLQLNSRLTRNKNASSETYINRFLIV---ILVALIAIVTLLYFLKR---------YNELFVIP 346
            .:|:.||.:....|.::.|..:|.||||   |||:...|.|:|.::.:         |||
Mouse   272 ETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQSEPFRDEPWYNE----- 331

  Fly   347 KLTYLGDATDSYSVKQ-FLQ---DYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENE 407
                   .|:|...:. ||:   |:|:|::||||:||:|:|||:|:|:.:||:|:.||.::::.|
Mouse   332 -------KTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEE 389

  Fly   408 TDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF----LFKKTRLEDEETKA 468
            ..:..:||||:|||||||:..:|:|||||||:|.|.|::|.|.|:.:    :.....|.|.....
Mouse   390 MGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHVYVPHVICNGQVLPDSSGID 454

  Fly   469 LLDINK---FSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITE 530
            ::|.:.   ....:.:||:|:.:||||||                                   :
Mouse   455 MIDSSPGVCGREREELFFRAICLCHTVQV-----------------------------------K 484

  Fly   531 ESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFA 595
            :.|                                      ..||..|.:
Mouse   485 DDH--------------------------------------CGDDVDGPQ--------------- 496

  Fly   596 RSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRR 660
                                                                             
Mouse   497 ----------------------------------------------------------------- 496

  Fly   661 AHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFI 725
                                      :||...|
Mouse   497 --------------------------KSPDAKS-------------------------------- 503

  Fly   726 FTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPRE---ETFQRLHV 787
              ..|.:|||||.||||....||..|         :|:...:|:...     ||   |.|:.|.|
Mouse   504 --CVYISSSPDEVALVEGVQRLGFTY---------LRLKDNYMEILN-----RENDIERFELLEV 552

  Fly   788 LEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIA 852
            |.|.|.|:||||||:.|.|:.:::.|||:|.:||.......:.|.   :.:...|..|||||.:|
Mouse   553 LTFDSVRRRMSVIVKSTTGEIYLFCKGADSSIFPRVIEGKVDQVR---SRVERNAVEGLRTLCVA 614

  Fly   853 RRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQ 917
            .:.:..|:|:|....|..|..:|::|::...|.|.:||.:|.|||||||||.||:..|||:.:||
Mouse   615 YKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKDLVLLGATAVEDRLQEKAADTIEALQ 679

  Fly   918 AAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYF-----IME--CKNREEMLLH---------- 965
            .||||:|||||||:|||.....:|        |.|     ::|  .|..||..||
Mouse   680 KAGIKVWVLTGDKMETASATCYAC--------KLFRRSTQLLELTTKKLEEQSLHDVLFDLSKTV 736

  Fly   966 ---LNALDREIIFGIG---QECALLIDGKSLGVAL-----AEASSEFRDVAVK----CTAVLCCR 1015
               ..::.|:...|:.   .:..|:|||.:|.:.:     ..:|..:|::.::    |:||||||
Mouse   737 LRCSGSMTRDSFSGLSTDMHDYGLIIDGAALSLIMKPREDGSSSGNYRELFLEICRNCSAVLCCR 801

  Fly  1016 LSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCM 1080
            ::||||:::|.|||.|.|:..|.:|||||||||||.|||||||::|:|||||||.:|:|..||..
Mouse   802 MAPLQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKH 866

  Fly  1081 LKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLP 1145
            ||::||||||::.:|:|.||.||||||:.|:...||:||...||..::||:.:|||||:.:||||
Mouse   867 LKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLP 931

  Fly  1146 ILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVL 1210
            ||..::.|:....:.|.|.|.||:....|..|.|..|:.|....::.:::.|:.|:..|....|.
Mouse   932 ILLYSLMEQHVGIDVLKRDPTLYRDIAKNALLRWRVFIYWTFLGVFDALVFFFGAYFIFENTTVT 996

  Fly  1211 LNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVI---NL 1272
            :| ||......||||:...:|:.|.|||.|::.|.::...|.|..|:|.::..::::..:   .|
Mouse   997 IN-GQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIWGSLLFYIAFSLLWGGVIWPFL 1060

  Fly  1273 DYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRAL 1316
            .|.. :|:.:.::|:|.|.||.||:.....|:||...::|.|.|
Mouse  1061 SYQR-MYYVFISMLSSGPAWLGIILLVTVGLLPDVLKKVLCRQL 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	441/1310 (34%)
Atp11a	NP_056619.1	P-type_ATPase_APLT_Dnf-like	47..986	CDD:319770	404/1190 (34%)
		MelB	<955..>1095	CDD:441813	40/141 (28%)