DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4301 and atp2b3a

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_005166875.1	Gene:	atp2b3a / 436745	ZFINID:	ZDB-GENE-040718-174	Length:	1299	Species:	Danio rerio

Alignment Length:	1257	Identity:	237/1257 - (18%)
Similarity:	381/1257 - (30%)	Gaps:	538/1257 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 NWHKGSR----------VSTINDWLQIQIGGPQDIKKKRPKG-QNRIKSTKYTLITFLPQNLLEQ 94
            ||.:|:.          |:..|||          .|:|:.:| |:||:..             ::
Zfish   153 NWIEGAAILLSVICVVLVTAFNDW----------SKEKQFRGLQSRIEQE-------------QR 194

  Fly    95 FRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVI 159
            |..:.|         |.:|..||:.|         :....|:..|.|:|           |.
Zfish   195 FAVVRN---------STVIQIPVAEM---------VVGDIAQVKYGDLL-----------PA--- 227

  Fly   160 RDGKEAIIKSQDV------IPGELIVVERDCDVPCDLVLLRST---DPHGKCFITTANLDGESN- 214
             ||  .:|:..|:      :.||...|.:..|.  |.:||..|   :..||..:|...::.::.
Zfish   228 -DG--VLIQGNDLKIDESSLTGESDHVRKSIDK--DPMLLSGTHVMEGSGKMLVTAVGVNSQTGI 287

  Fly   215 LKTLMVPRDL-------------------PTVDLPEMHKL------GIIE---------CESPTT 245
            :.||:...::                   |:|:..| |.:      |.:|         .|:...
Zfish   288 IFTLLGAGEMEEEKKDCKKEVNSNSSTQFPSVEAKE-HNIINGKQDGTLENNQNKAKKQDEAVAM 351

  Fly   246 DLYSF----NGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRN 306
            ::...    .|::|.|..:...:| ..|..:|:|...|       .||..|...
Zfish   352 EMQPLKSAEGGEVEEKEKKKASVP-KKEKSVLQGKLTK-------LAVQIGKAG----------- 397

  Fly   307 KNASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFL 371
                          :::.|:..|:.:|||:.:   .|::.|..:|.:.|..| |:.|::.::..:
Zfish   398 --------------LVMSAITVIILMLYFVIK---TFIVHKQPWLTECTPIY-VQYFVKFFIIGV 444

  Fly   372 ILFNYLIP--ISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKT 434
            .:....:|  :.|.|||.|...:.....:.:|            |...:..|.:|....:.||||
Zfish   445 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL------------VRHLDACETMGNATAICSDKT 497

  Fly   435 GTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSL 499
            ||||.|.|...|..|...  ||:.....|:       ||.               .|:::.|.::
Zfish   498 GTLTTNRMTVVQIYIGDQ--LFRDIPTPDQ-------INP---------------RTLELISSAI 538

  Fly   500 EQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIIS 564
            ....|.|:|..|  |.|.|
Zfish   539 AVNCAYTSKIMP--ADKEG---------------------------------------------- 555

  Fly   565 SDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFR 629
                         |:                                   |..|.|..|
Zfish   556 -------------GL-----------------------------------PKQVGNKTE------ 566

  Fly   630 PISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR 694

Zfish   567 ----------------------------------------------------------------- 566

  Fly   695 ESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL 759
                                                             ||.||:|
Zfish   567 -------------------------------------------------CALLGLV--------- 573

  Fly   760 RVRIVPPHMDYKRPFAKPREETFQRL--HVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPL 822
                    :|.|:.:...||:..:.|  .|..|.|.||.||.:::..||...:|:|||...:...
Zfish   574 --------LDLKQDYQAVREQIPEELLYKVYTFNSVRKSMSTVIQMPDGSFRLYSKGASEILLKK 630

  Fly   823 C--------------ANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANS 873
            |              |....|:|.|.   |...|..||||:.||.|.:..:...|:
Zfish   631 CSFILSRDGEARAFRARDKDEMVKKV---IEPMACDGLRTICIAYRELPADPLPDW--------- 683

  Fly   874 SLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIA 938
              :|.        ..|.|||..:....:||.::.:|.|.:...|.|||.:.::|||.:.||..||
Zfish   684 --DNE--------TDIVSNLTCITVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARAIA 738

  Fly   939 LSCGHIPPDAKKYFIMECKN-----REEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEAS 998
            ..||.|.| ...:..||.|:     |.|.    ..:::|.|..|..:..:|
Zfish   739 AKCGIIHP-GDDFLCMEGKDFNRRIRNEK----GEIEQERIDKIWPKLRVL-------------- 784

  Fly   999 SEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSS---NENYNTASIGDGANDVSMIQEAHVGIGIM 1060
                           .|.||..|..:|..|..|   .:....|..|||.||...:::|.||.. |
Zfish   785 ---------------ARSSPTDKHTLVKGIIDSTVVEQRQVVAVTGDGTNDGPALKKADVGFA-M 833

  Fly  1061 GREGRQAARCA------DFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQF 1119
            |..|...|:.|      |..|:.  ::|.::.....|.|:  |..:.:....|:|.:.:.|....
Zfish   834 GIAGTDVAKEASDIILTDDNFSS--IVKAVMWGRNVYDSI--SKFLQFQLTVNVVAVIVAFTGAC 894

  Fly  1120 HTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLM 1184
            .|..|.......|::.|....:.||     |::.:|.||..|:|.|  |.:|.       |....
Zfish   895 ITQDSPLKAVQMLWVNLIMDTFASL-----ALATEPPTEALLLRKP--YGRNN-------PLISR 945

  Fly  1185 WVL-----FAIYHSVIIFYFAF 1201
            .::     .|:|..||||...|
Zfish   946 TMMKNILGHAVYQLVIIFTLLF 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	12/64 (19%)
		ATPase-Plipid	74..1317	CDD:273734	226/1213 (19%)
		E1-E2_ATPase	127..>345	CDD:278548	46/265 (17%)
		Cation_ATPase	<734..823	CDD:289987	23/90 (26%)
		HAD_like	<1036..1066	CDD:304363	12/29 (41%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	34/145 (23%)
atp2b3a	XP_005166875.1	ATPase-IIB_Ca	23..1082	CDD:273668	237/1257 (19%)
		Cation_ATPase_N	57..116	CDD:279080
		E1-E2_ATPase	164..484	CDD:278548	77/429 (18%)
		Cation_ATPase	545..634	CDD:289987	35/321 (11%)
		HAD	627..825	CDD:289480	61/253 (24%)
		Cation_ATPase_C	899..1077	CDD:279079	22/83 (27%)
		ATP_Ca_trans_C	1122..1198	CDD:289209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000