DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP9B

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_011524265.1	Gene:	ATP9B / 374868	HGNCID:	13541	Length:	1174	Species:	Homo sapiens

Alignment Length:	1335	Identity:	360/1335 - (26%)
Similarity:	555/1335 - (41%)	Gaps:	352/1335 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 WLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVS 118
            ||    |.|:..::|.|:  |.||:.||.:.||:|..|.|||:...|.||||::....:....:.
Human   120 WL----GCPEKCEEKHPR--NSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIG 178

  Fly   119 PM-TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNS---SPVTVIRDGKEAIIKSQDVIPGELIV 179
            .: |...||.||:|||..::..::..|::.|..|||   |.:||  .|| ..:||.|:..|:||:
Human   179 YLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQLYSKLTV--RGK-VQVKSSDIQVGDLII 240

  Fly   180 VERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDLPEMHKL----GIIEC 240
            ||::..:|.|:|.||:::..|.|||.|..||||::.| |.|.... |..||.:..|    ..:..
Human   241 VEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWK-LKVAVSC-TQQLPALGDLFSISAYVYA 303

  Fly   241 ESPTTDLYSFNGKIELKGGEGRV-LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLT 304
            :.|..|::||.|....:..:..: ..||.||.|. .|.:..:..|||..:|||..::..:|:...
Human   304 QKPQMDIHSFEGTFTREDSDPPIHESLSIENTLW-ASTIVASGTVIGVVIYTGKETRSVMNTSNP 367

  Fly   305 RNKNASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLS 369
            :||....:..:||....:.:||:|:..::..|:.:                    |..:.::...
Human   368 KNKVGLLDLELNRLTKALFLALVALSIVMVTLQGF--------------------VGPWYRNLFR 412

  Fly   370 FLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKT 434
            ||:||:|:|||||.|.:::.:.:..|.|      .::|.....||.||.:.||||::..|.:|||
Human   413 FLLLFSYIIPISLRVNLDMGKAVYGWMM------MKDENIPGTVVRTSTIPEELGRLVYLLTDKT 471

  Fly   435 GTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSL 499
            ||||:|||            :||:..         |....:.|:.....|:    |.....|...
Human   472 GTLTQNEM------------IFKRLH---------LGTVSYGADTMDEIQS----HVRDSYSQMQ 511

  Fly   500 EQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIIS 564
            .||........|:...:|..|::.  ..::...|.|                      |.:.::.
Human   512 SQAGGNNTGSTPLRKAQSSAPKVR--KSVSSRIHEA----------------------VKAIVLC 552

  Fly   565 SDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFR 629
            .:|.|:..|..|           :.....||.:::           :.:|.|..
Human   553 HNVTPVYESRAG-----------VTEETEFAEADQ-----------DFSDENRT----------- 584

  Fly   630 PISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR 694

Human   585 ----------------------------------------------------------------- 584

  Fly   695 ESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETL 759
                                               ||||||||.|||:...::|:.....|..:
Human   585 -----------------------------------YQASSPDEVALVQWTESVGLTLVSRDLTS- 613

  Fly   760 RVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRD-TDGKKWIYTKGAESYVFPL- 822
                    |..|.|..:..  :|..|.:..|||:.|||.||||| :..:...|.|||:..:.|:
Human   614 --------MQLKTPSGQVL--SFCILQLFPFTSESKRMGVIVRDESTAEITFYMKGADVAMSPIV 668

  Fly   823 ---------CANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDF------LVE----- 867
                     |.|               .||.|||||.:|::.::||:||||      .||
Human   669 QYNDWLEEECGN---------------MAREGLRTLVVAKKALTEEQYQDFEPMQSSSVESTHST 718

  Fly   868 ---------------LAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQ 917
                           ..||..|:.:|..........:|..::||..|.|||.||.||..||..|:
Human   719 YTCAHRRLPLCPQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLR 783

  Fly   918 AAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECA 982
            .||||||:|||||:|||..||.|...:......:...:..:|.|..|.|||..|:      .:||
Human   784 NAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNAFRRK------HDCA 842

  Fly   983 LLIDGKSLGVALAEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDV 1047
            |:|.|.||.|.|.....||.::|.:|.||:|||.||.||:.:|:|:: .:....|.:||||.|||
Human   843 LVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQ-QHTGRRTCAIGDGGNDV 906

  Fly  1048 SMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMG 1112
            ||||.|..||||.|:||:||:..|||:..:|..:.|||:|||.....|.:.|..:..::.::...
Human   907 SMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIIST 971

  Fly  1113 IMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISE--KPYTEEKLMRTPQLYKKNTDNK 1175
            :..:|.....|:|..:|....:..|..|||..|:..:.:.:  ||   |..|..|:|||..|..:
Human   972 MQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKP---EMAMLYPELYKDLTKGR 1033

  Fly  1176 QLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWL 1240
            .|.:..||:|||.:||...|:.|.|...|....|     ..||.|....:|...::|.:.::.|.
Human  1034 SLSFKTFLIWVLISIYQGGILMYGALVLFESEFV-----HVVAISFTALILTELLMVALTVRTWH 1093

  Fly  1241 ESMYLSFWYIFTIIISILGFV-------------------VTTVIYNVINLDYDTDIYWAYNNLL 1286
            ..|.::.:......:|.|.|:                   :|||.:
Human  1094 WLMVVAEFLSLGCYVSSLAFLNEYFGIGRVSFGAFLDVAFITTVTF------------------- 1139

  Fly  1287 ASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSF 1321
                :|....:|.|:|| |.|.::.|:|.|:..|:
Human  1140 ----LWKVSAITVVSCL-PLYVLKYLRRKLSPPSY 1169

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	21/64 (33%)
		ATPase-Plipid	74..1317	CDD:273734	352/1309 (27%)
		E1-E2_ATPase	127..>345	CDD:278548	70/225 (31%)
		Cation_ATPase	<734..823	CDD:289987	30/99 (30%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	65/269 (24%)
ATP9B	XP_011524265.1	PhoLip_ATPase_N	125..182	CDD:292826	19/58 (33%)
		ATPase-Plipid	132..1169	CDD:273734	354/1317 (27%)
		E1-E2_ATPase	224..427	CDD:278548	68/226 (30%)
		Cation_ATPase	579..661	CDD:289987	34/203 (17%)
		HAD_like	<881..922	CDD:304363	21/41 (51%)
		PhoLip_ATPase_C	927..1166	CDD:292829	66/270 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920