DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp11c

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_009289452.1	Gene:	atp11c / 368385	ZFINID:	ZDB-GENE-030616-51	Length:	1139	Species:	Danio rerio

Alignment Length:	1339	Identity:	443/1339 - (33%)
Similarity:	652/1339 - (48%)	Gaps:	330/1339 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQG 138
            |||.|:|||:..|||:||.||||||||||||::.::.:::|:|.||:||.|||.|||.|||.|||
Zfish    43 NRIVSSKYTVWNFLPKNLFEQFRRIANFYFLIIFLVQVIVDTPTSPVTSGLPLFFVITVTAIKQG 107

  Fly   139 YEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCF 203
            |||.||::.||.||..||||:.||:....:|:.:..|:::.|..|...||||:||:|:...|.||
Zfish   108 YEDWLRHKADNEVNKYPVTVLEDGRSVKKESEKIKVGDVVEVVEDETFPCDLILLQSSREDGTCF 172

  Fly   204 ITTANLDGESNLKT-LMVP---RDLPTVDLPEMHKLGIIECESPTTDLYSFNGKIEL--KGGEGR 262
            :|||:||||||.|| ..||   |||..:       ...||||.|..|||.|.|::.:  ...|..
Zfish   173 VTTASLDGESNHKTHYTVPDIERDLQVL-------TAAIECEQPQPDLYKFVGRMHIYKPEQEEA 230

  Fly   263 VLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALI 327
            |..|..||:||:|:.:|||:.:.|.||||||.:|:.||.:....|.::.|..||.||:|.|..||
Zfish   231 VRSLGPENLLLKGATLKNTKEIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLLVYLCILI 295

  Fly   328 --AIV--TLLYFLKR--------YNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPI 380
              |:|  ||.|..:.        |||      .|.....|:.| :|.| .|:|||::|||::||:
Zfish   296 SKAVVCTTLKYVWQSKEGQDEPWYNE------KTQKEKETNMY-LKMF-TDFLSFMVLFNFIIPV 352

  Fly   381 SLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQ 445
            |:|||:|:|:.:||:|::||.:.::.|.::..:||||:|||||||:..:|:|||||||:|.|.|.
Zfish   353 SMYVTVEMQKFLGSFFIKWDNDFFDPEIEEGALVNTSDLNEELGQVEYVFTDKTGTLTQNNMEFI 417

  Fly   446 QCSINGNKFLFKKTRLE-DEETKALLDINKFS-----ANQRVFFQALSICHTVQVASGSLEQADA 504
            :|.|:|.::..:....| |..|.....:||..     ..:.:|.:||.:||||||...:|
Zfish   418 ECCIDGFQYRHRDAHGELDGFTVTDGPLNKLQEKAGREKEELFLRALCLCHTVQVKEETL----- 477

  Fly   505 GTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNP 569

Zfish   478 ----------------------------------------------------------------- 477

  Fly   570 LLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQ 634
               ||...|::                                        ||.|
Zfish   478 ---SDQIDGID----------------------------------------GVLP---------- 489

  Fly   635 FRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAA 699

Zfish   490 ----------------------------------------------------------------- 489

  Fly   700 PTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIV 764
                       :||      |.|.||      ||||||.|||:.....|..:.|.:::.:::|
Zfish   490 -----------KAE------EERGFI------ASSPDEVALVKGAMEYGFTFLGLENKNMKIR-- 529

  Fly   765 PPHMDYKRPFAKPRE---ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANS 826
                        .|:   |.::.||||.|...|:||||||:...|...::.|||:|.:||   ..
Zfish   530 ------------NRQNDIEEYKLLHVLNFDPVRRRMSVIVQTKSGDTLLFCKGADSSIFP---RV 579

  Fly   827 SAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIES 891
            ..|.|.:...|:...|..|.|||.:|.:.:|.|||......|.:|..:|::|::.....|.::|:
Zfish   580 RPEEVDRIRLHVERNATDGYRTLCVAYKQLSAEEYALADTGLREARLALQDREEKLMAMYNQVET 644

  Fly   892 NLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYF---- 952
            .:.|:|||||||.||::.|:|:.:||.||:|||||||||:|||.:...:|        :.|
Zfish   645 GMSLIGATAVEDRLQEEAAETMEALQGAGMKIWVLTGDKMETAKSTCYAC--------RLFQRGT 701

  Fly   953 -IMEC---------KNREEMLLH-LNALDREII--------------FGIGQECALLIDGKSLGV 992
             ::|.         ..||:.||. |....|..:              :...||...:|||.:|.:
Zfish   702 ELLELTVRTLEDGRSKREDRLLELLRDYHRRAVQDAPPVKTGVVTRSWSANQEYGFIIDGATLSL 766

  Fly   993 AL-----AEAS---SEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSM 1049
            .:     |:||   ..|..:...||||||||::||||:::|.::|:...:..|.|||||||||||
Zfish   767 VMNPPRDADASLYRGLFLQICQNCTAVLCCRMAPLQKAQIVKMVKNCKGSPITLSIGDGANDVSM 831

  Fly  1050 IQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIM 1114
            |.||||||||.|:|||||.|.:|:|..|...||:|||.|||.:.||::.||.||||||:.|:...
Zfish   832 ILEAHVGIGIKGKEGRQAVRNSDYAIPKLKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQ 896

  Fly  1115 FLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHW 1179
            ||:||...:|...:||:.:||:||:.:||:|||..::.|:....|.|:....||::...|..|.|
Zfish   897 FLYQFFCGYSQQPLYDAAYLTMYNICFTSMPILAYSLLEQHIAIEILLDNATLYREIAKNAMLRW 961

  Fly  1180 PYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMY 1244
            ..||.|.:..|:.. ::|:|...|.:.|..|.:.||......:||::...:|..|.|||.|::.:
Zfish   962 RPFLYWTVLGIFQG-LLFFFGVRFLFSNPALQDNGQVFGNWSYGTIVFTVLVFTVTLKLALDTRH 1025

  Fly  1245 LSFWYIFTIIISILGFVVTTVIYNVINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDY 1307
            .::...|.|..|:..:|..:..:..|...:  ...:|:.:.|:|:|:..||.||:..:..|:|:.
Zfish  1026 WTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRLYFVFANMLSSVSAWLVIIILILLSLLPEI 1090

  Fly  1308 TIRMLQRALNIKSFSIFPGKQ------------RKLKMR 1334
            .:.:|::.....|....||:.            |.|.||
Zfish  1091 LLAVLRKPKGPHSRQKKPGQSNVGGIPSSQSSARPLLMR 1129

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	28/46 (61%)
		ATPase-Plipid	74..1317	CDD:273734	436/1308 (33%)
		E1-E2_ATPase	127..>345	CDD:278548	103/235 (44%)
		Cation_ATPase	<734..823	CDD:289987	31/91 (34%)
		HAD_like	<1036..1066	CDD:304363	24/29 (83%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	82/250 (33%)
atp11c	XP_009289452.1	PhoLip_ATPase_N	31..90	CDD:292826	28/46 (61%)
		ATPase-Plipid	40..1075	CDD:273734	429/1283 (33%)
		Cation_ATPase	466..578	CDD:289987	52/339 (15%)
		HAD_like	<819..850	CDD:304363	26/30 (87%)
		PhoLip_ATPase_C	850..1075	CDD:292829	75/225 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578118
Domainoid	1	1.000	219	1.000	Domainoid score	I2576
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	748	1.000	Inparanoid score	I555
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.870