DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp10a

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001135407.1	Gene:	Atp10a / 365266	RGDID:	1306150	Length:	1508	Species:	Rattus norvegicus

Alignment Length:	1425	Identity:	444/1425 - (31%)
Similarity:	697/1425 - (48%)	Gaps:	280/1425 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 GPQDIKKKRPKGQ-------------NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLL 112
            |.:|......||:             ||:|:|||||::|||:||.|||.|:||.||:.:.:::.:
  Rat    40 GTEDSTAGASKGERLLMRGCIQHLADNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFV 104

  Fly   113 -IDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVI-RDGKEAIIKS-QDVIP 174
             ..:...|:.:|.|::|::||||.|..:||..|:|:|:.:|.....|. |:.|:.:.:. :::..
  Rat   105 PAVNAFQPVLALAPVLFILAVTAIKDLWEDYSRHRSDHEINHLGCLVFSREEKKYVNRYWKEIRV 169

  Fly   175 GELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDLPEMHKL---G 236
            |:.:.:..:..:|.|::||.|:||.|.|.|.|||||||:|||...|.|....: :.|.:.|   .
  Rat   170 GDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDGETNLKRRQVVRGFSEL-VSEFNPLTFTS 233

  Fly   237 IIECESPTTDLYSFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNS 301
            :||||.|..||..|.|.|....||  ...|..||:||||..::|||.|.|..:|.|..:|..||:
  Rat   234 VIECEKPNNDLSRFRGCIIHSNGE--KAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNN 296

  Fly   302 RLTRNKNASSETYIN-----RFLIVILVALIAIVTLLYFLKRYNE---LFVIPKLTYLGDATDSY 358
            ...|.|.:..|..:|     ..|:::.::|.:.|....:::||.|   ||.:|:    .|.:...
  Rat   297 SGPRYKRSQLERQMNCDVLWCVLLLVCISLFSAVGHGLWVRRYQEKKALFDVPE----SDGSSLS 357

  Fly   359 SVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEEL 423
            .....:..:|:.:|:...||||||||:||:.:|...:|:..|:|||:.|||........|:.|:|
  Rat   358 PATAAVYSFLTMIIVLQVLIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDL 422

  Fly   424 GQINILFSDKTGTLTKNEMNFQQCSINGNKF--------LFKKTRLEDEETKALLDINKFS-ANQ 479
            |||..:|||||||||:|:|.|::|:::|.::        |.|....:.||.:.:..:...| ...
  Rat   423 GQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANAQRLAKYQEADSEEEEMVSKVGPISHRGS 487

  Fly   480 RVFFQALSICHTVQVASGSLEQADAGTAKREPV----TAIKSGPPEMYSISDITEESHNASQQSE 540
            ....|::.:.|..|.............|||..:    ||. |.|.|    .|||.:.....:.||
  Rat   488 TGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAF-SSPME----KDITPDPKLLEKVSE 547

  Fly   541 ----LNVGHTIDNSVSAHPNG--------------VNSTIISSDVNPLLVSDDGYGVERRKRPV- 586
                |::....::.: ||.:.              .|:.:::|...|           |:|..|
  Rat   548 CDRFLSIARHQEHPL-AHLSPELSDVFDFFIALTICNTVVVTSPDQP-----------RQKVRVR 600

  Fly   587 -----VIKRSPNFARS---NRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKD 643
                 .:|...:|.|.   :|:.:|.:|..|:..   |..:|  :..:.|.|       |.|:.:
  Rat   601 FELKSPVKTIEDFLRKFTPSRLASGCSSIGNLTN---NKSSN--KSGSTFLP-------SLSQDN 653

  Fly   644 LQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSR--ESYAAPTFTRQP 706
            :....|...||                 |.||.||...|....::.|.||.  .....|...|
  Rat   654 MLLRLEERLGQ-----------------TAPVIASNGYASQASQAESWTSECTSEQKCPGDQR-- 699

  Fly   707 TILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEA-----CANLGMVYTGDDDETLRVRIVPP 766
                    ::::.|:|       |:|.||||.|||.|     ||.:..::.       :|.:..|
  Rat   700 --------EQQEGELR-------YEAESPDEAALVYAAKAYNCALVDRLHD-------QVSVELP 742

  Fly   767 HMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRD--TDGKKWIYTKGAESYVFPL---CANS 826
            |:.         ..||:.||.|.|.|.||||||::|.  ||... :|||||:|.|..|   |::.
  Rat   743 HLG---------RLTFELLHTLGFDSIRKRMSVVIRHPLTDEIN-VYTKGADSVVMDLLLPCSSD 797

  Fly   827 SA------ELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEEC 885
            .|      ::.:||..:::.:|..|||||.||:|::|:|||..:|....:|.:|:|:|::|..:.
  Rat   798 DARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAETSVESREELLFQS 862

  Fly   886 YAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKK 950
            ..::|:||.|||||.:||.|||.|.:|:..|:.||::||||||||.|||:|||.:|
  Rat   863 AVRLETNLHLLGATGIEDRLQDGVPETIAKLRQAGLQIWVLTGDKQETAINIAYAC--------- 918

  Fly   951 YFIMECKNREEMLLHLNALDREIIFGIGQEC---------------------------------- 981
                :..:..|.::.|||..||....:..:|
  Rat   919 ----KLLDHGEEVITLNADSREACAALLDQCLCYVQSRNSRSVPQNSESSFSVGFSFNPASTSTD 979

  Fly   982 -----ALLIDGKSLGVALAEA-SSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASI 1040
                 :|:|||:||..||.:: ..:|..:|.:|.:|||||.:|||||.||.|:::..:.. |.:|
  Rat   980 SSPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRNKLKAM-TLAI 1043

  Fly  1041 GDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFY 1105
            |||||||||||.|.||:||.|:||.||...:|||..:|..|:|||:||||:...||:.:||||||
  Rat  1044 GDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFY 1108

  Fly  1106 KNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKK 1170
            ||.:|:|::|.|||:..||:|::.|..:|..:|::::|||.|...:.:|....:.|:|.|||||.
  Rat  1109 KNTMFVGLLFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLRKPQLYKS 1173

  Fly  1171 NTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNV-LLNYGQTVAFSCFGTLLM------- 1227
            ..:.::.....|.:.::.|.:.|::.|:..:..:|.::| :..:|..|......|.|:
  Rat  1174 GQNMEEYSPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDVFTWGTPVTAIALFTFLLHLGIETK 1238

  Fly  1228 -WTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDI---------YWAY 1282
             ||         ||..:...|               :|.::..:.|.|:|..         ||..
  Rat  1239 TWT---------WLNWLACGF---------------STFLFFSVALIYNTSCATCYPPSNPYWTM 1279

  Fly  1283 NNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFP-----GKQRKLKMREKF 1337
            ..||.....:|..::..||.|:|....:.||.       |:||     |:|...|...||
  Rat  1280 PTLLGDPLFYLTCLIAPVAALLPRLFFKALQG-------SLFPTQLQLGRQLAKKSLNKF 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	26/73 (36%)
		ATPase-Plipid	74..1317	CDD:273734	432/1372 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	81/230 (35%)
		Cation_ATPase	<734..823	CDD:289987	37/98 (38%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/266 (29%)
Atp10a	NP_001135407.1	P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	406/1238 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820