DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp13a2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_006239308.1	Gene:	Atp13a2 / 362645	RGDID:	1307977	Length:	1173	Species:	Rattus norvegicus

Alignment Length:	1284	Identity:	229/1284 - (17%)
Similarity:	385/1284 - (29%)	Gaps:	536/1284 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGY-------------EDILRYRT--------D 148
            |.:.:.||:|..::|....  ..|.||:..|...|             ..:..|:|        |
  Rat   220 VKSYLQLLVDEALNPYYGF--QAFSIALWLADHYYWYAVCIFLISAISICLSLYKTRKQSMTLRD 282

  Fly   149 NVVNSSPVTVIR-DGKEAIIKSQDVIPGELIVVERDCD-VPCDLVLLRSTDPHGKCFITTANLDG 211
            .|..|..|.|.| .|:|..:.|.:::||:.:|:.::.. :|||..|:.     |:|.:..::|.|
  Rat   283 MVKLSVRVQVCRPGGEEEWVDSSELVPGDCLVLPQEGGMMPCDAALVA-----GECVVNESSLTG 342

  Fly   212 ES--NLKTLMVPRDLPTVDLPEMHKLGIIECESPTTDLYSFNGKIELKGGEGRVLPLSTENVLLR 274
            ||  .|||.: |.. |....||.|:...:.|.:......::.|.        |||.:.|....
  Rat   343 ESIPVLKTAL-PEG-PQPYCPETHRRHTLFCGTLVLQARAYLGP--------RVLAVVTRTGF-- 395

  Fly   275 GSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIVTLLYFLKRY 339
                        |....|::|.: |:.|     ..|.:.|.:....|..::::|::..:|
  Rat   396 ------------CTAKGGLVSSI-LHPR-----PISFKFYRHSMKFVAALSVLALLGTIY----- 437

  Fly   340 NELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRV------------- 391
                                         |.:||:...:|:...|...|..|
  Rat   438 -----------------------------SIIILYRNRVPVKEIVIRALDLVTVVVPPALPAAMT 473

  Fly   392 IGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQ-QCSINGNKFL 455
            :.:.:.:..|.........|..:|..      |::.::..|||||||::.::.. ...:.|...|
  Rat   474 VCTLYAQSRLRTQGIFCIHPLRINLG------GKLRLVCFDKTGTLTEDGLDIMGVVPLKGQMLL 532

  Fly   456 FKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPP 520
                .|..|.                       ||.                           ||
  Rat   533 ----PLVPEP-----------------------CHL---------------------------PP 543

  Fly   521 EMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRP 585
                                   |..:...|:.|        ..|.::..||.|
  Rat   544 -----------------------GPLLRALVTCH--------ALSQLHDTLVGD----------- 566

  Fly   586 VVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEA 650
                                                        |:.|:...||       .|..
  Rat   567 --------------------------------------------PMDLKMVEST-------GWVL 580

  Fly   651 PSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQ 715
            ..|.|.|
  Rat   581 EEGSAAG---------------------------------------------------------- 587

  Fly   716 RRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE 780
                             |:|:.:.||                   |...||    :.|  :.:||
  Rat   588 -----------------SAPETQVLV-------------------VMRPPP----RGP--QQQEE 610

  Fly   781 TFQRLHVLE---FTSDRKRMSVIVRDTDGKKW-------IYTKGAESYVFPLCANSSAELVTKTD 835
            :.:.:.||.   |:|..:||.|:|      .|       .|.||:...|..||   |.|.|.:..
  Rat   611 SPEPVSVLRRFPFSSALQRMDVVV------TWPGATQPEAYVKGSPELVASLC---SPETVPRDF 666

  Fly   836 AHI-SDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGAT 899
            ..: ..:...|.|.:|:|.:.:             ....|||..:||:.:   .:|..|.|||..
  Rat   667 PQVLQSYTAAGYRVVALAGKPL-------------PTAPSLEAAQQLTRD---TVEQELSLLGLL 715

  Fly   900 AVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLL 964
            .:.:.|:......:.:|:..||:..::|||.::||:.:|.:||.:             ..:|.|.
  Rat   716 VMRNLLKPQTTPVIQTLRKTGIRTVMVTGDNLQTAVTVAKACGMV-------------GTQEHLA 767

  Fly   965 HLNALDREIIFGIGQECALLIDGKSLGVAL-------------AEASSEFRDVA----------- 1005
            .::|...|    .||..||.........|:             .|..|:.|.:|
  Rat   768 IIHATHPE----QGQPAALEFLPTEPSAAMNGAKDPVQATDYPVEPESQSRHLALSGSTFAVLQK 828

  Fly  1006 --------VKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGR 1062
                    |...|.:..|::|.||:::|..::  ...|.....||||||...::.|.|||.:...
  Rat   829 HFPKLLPKVLVQATVFARMAPEQKTQLVCELQ--RLQYCVGMCGDGANDCGALKAADVGISLSQA 891

  Fly  1063 EGR-------------------QAARCA-DFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKN 1107
            |..                   :..||: |.:|:.|   |.:.|                  |..
  Rat   892 EASVVSPFTSSMASIECVPTVIREGRCSLDTSFSVF---KYMAL------------------YSL 935

  Fly  1108 IVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTP---QLYK 1169
            ..|:.::.|:..:|     ::.|..||.:...|.|::.:|             :.||.   .|.:
  Rat   936 TQFISVLILYTINT-----NLGDLQFLAIDLFITTTVAVL-------------MSRTGPALTLVR 982

  Fly  1170 KNTDNKQLHWPYFLMWVLFAIYHSVIIF-------YFAFC----FFYYNNV------LLNYGQTV 1217
            .......|..|     ||.::...|.:.       ||...    |...|..      |.||..||
  Rat   983 ARPPGALLSVP-----VLGSLLLQVALVAGIQLGGYFLVIAQPWFVPLNRTVPAPDNLPNYENTV 1042

  Fly  1218 AFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVI 1266
            .||..|...:.....|.....:.:.:|.:  ..|.:.:::||.|:..:|
  Rat  1043 IFSLSGFQYLILAAAVSKGAPFRQPLYTN--VPFLVALALLGSVLVGLI 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	5/15 (33%)
		ATPase-Plipid	74..1317	CDD:273734	229/1284 (18%)
		E1-E2_ATPase	127..>345	CDD:278548	53/242 (22%)
		Cation_ATPase	<734..823	CDD:289987	22/98 (22%)
		HAD_like	<1036..1066	CDD:304363	11/48 (23%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	44/220 (20%)
Atp13a2	XP_006239308.1	P-ATPase-V	39..1116	CDD:273738	229/1284 (18%)
		P5-ATPase	39..>110	CDD:289194
		E1-E2_ATPase	258..493	CDD:278548	56/303 (18%)
		Cation_ATPase	<621..658	CDD:289987	13/45 (29%)
		COG4087	<843..>892	CDD:226572	16/50 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000