Protein Alignment CG4301 and dnf1

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_001342913.1
• Gene: dnf1 / 3361515
• PomBaseID: SPAC821.13C
• Length: 1562
• Species: Schizosaccharomyces pombe
• Alignment Length: 1575
• Identity: 408/1575 - (25%)
• Similarity: 631/1575 - (40%)
• Gaps: 530/1575 - (33%)

  Fly    47 RVSTIN---DWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTI 108
            |:..||   |..||      |.:..:|..||.|.|::|....|:|..::.||.:.||.|||::.|
pombe   210 RIIIINPYDDSSQI------DERTGKPYMQNSIVSSRYNKYNFVPLQIIAQFSKTANCYFLLIAI 268

  Fly   109 ISLLID-SPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIR------------ 160
            :.::.. |.....|:::||:..|::...::|:::..|||.|.|.|.....|:|
pombe   269 MQMIPGWSTTGTYTTIIPLLIFISIAILREGFDNYRRYRQDRVENRIQTQVLRHVDVDPPIVEEH 333

  Fly   161 --------------------------DGKE----------------------------------- 164
                                      |.:|
pombe   334 SSFFRRRRWRRSRSQESASRSTIRSTDEREPERTSEDPPQLPPSPSSPSSPALSVKPNIDPQPPL 398

  Fly   165 --------------------AIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANL 209
                                |....:||..|::|.:..|..:|.|::.|.|.:|:|..:|.||.|
pombe   399 YNSTLTTTRSIPANKPTFFWASCDRKDVRVGDIIRLTSDQTLPADVIALSSPNPNGAIYIETAAL 463

  Fly   210 DGESNLKTLMVPRDLPTV--DLPEMHKL-GIIECESPTTDLYSFNGKIELKGGEGRVLPLSTENV 271
            |||::|||.:|...|.::  |:.::.:| |....|.|..|||:|||.::|...:|.: |||..:|
pombe   464 DGETSLKTRLVNSTLRSLCKDINDLIRLSGTCTVEDPNGDLYNFNGSMKLDSIQGEI-PLSNNDV 527

  Fly   272 LLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRN---KNASSETYINR---FLIVILVALIAIV 330
            |.|||.::||..:....::||..||:::|:  .||   |..|.:...||   |:..::|::....
pombe   528 LYRGSNLRNTSELFALVIFTGEESKIRMNA--VRNVSVKAPSMQKVTNRIVIFIFALVVSMAIYC 590

  Fly   331 TLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSW 395
            |..||:.:..   |..||.||     :.|...|:...:||:||:|.::||||||::|:.||..::
pombe   591 TAAYFVWQKK---VERKLWYL-----TNSKLSFVPILVSFIILYNTMVPISLYVSMEIIRVFQTF 647

  Fly   396 FMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTR 460
            .::.|::||..|.|..|.|.:|::.|||||:..:|||||||||.|.|.|:..|:.|  |.::...
pombe   648 LVQSDIDLYYPENDTRCEVRSSSILEELGQVTHVFSDKTGTLTDNIMLFRNLSVGG--FAWQHVG 710

  Fly   461 LEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSI 525
            .|:.:.        .|.:|:               |..|:    |.||          ||::.:|
pombe   711 AENPKL--------VSTSQK---------------SDDLD----GEAK----------PPQLENI 738

  Fly   526 SDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKR 590
            .                 |.||......|.|
pombe   739 Q-----------------GTTIQLLQYVHDN---------------------------------- 752

  Fly   591 SPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQA 655
                                             |.|.|   |.:.|
pombe   753 ---------------------------------PHTTF---SKRVR------------------- 762

  Fly   656 PGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNE 720
                         .:|.|.....|                  ..|:|..:             |:
pombe   763 -------------IFLLNLAICHT------------------CLPSFDEE-------------NQ 783

  Fly   721 IRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRL 785
            |      ..||:.||||.|||.|...||.:....|.::|.:|:..|...:..|.||    |::.|
pombe   784 I------YKYQSISPDELALVHAAQQLGYIVIDRDIDSLTIRLHYPLDPHSHPIAK----TYRIL 838

  Fly   786 HVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVF------------------------------ 820
            :::||||.||.||||||..:|:..::.|||:|.:.
pombe   839 NIIEFTSKRKCMSVIVRMPNGRICLFCKGADSAIIKRLRLSNLAKRKDKSVTKAEQARKSIEIDK 903

  Fly   821 -----------------------------------------------PLCANS------------ 826
                                                           |..:.|
pombe   904 AIIRNSQSTSRPSLTASRPSLSRRRNDYINNVTSWLDERREKMGVVRPRASTSILETRRRPAVGR 968

  Fly   827 ---------------------------------SAELVTKTDAHISDFARLGLRTLAIARRLISE 858
                                             .|:|...|..|:..||..|||||..|.|.|.|
pombe   969 HSLAGGERLMEDKKYLSKQEEAEGSIYESLNHNDAKLFENTFEHVHAFATDGLRTLMYAHRFIDE 1033

  Fly   859 EEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKI 923
            .|||.:.:....|.:||.||:||.:|....||.:|:..||||:||.||..|.:::.||..||||.
pombe  1034 SEYQSWKLVNDAALNSLSNRQQLLDEAADLIEKDLEFAGATAIEDKLQVGVPESINSLFRAGIKF 1098

  Fly   924 WVLTGDKVETALNIALSCGHI-------------------------------------PPDAKKY 951
            |:|||||.|||:||..|||.|                                     |.....:
pombe  1099 WMLTGDKKETAINIGHSCGVIKEYSTVVVMGSLDGVEGSDETVSGGQRLSLDRPPTNDPASLMIH 1163

  Fly   952 FIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASSE----FRDVAVKCTAVL 1012
            .::.|.|    .:|.|:|...:|         :|||.:|  |..|...|    |.:.||:..:|:
pombe  1164 QLISCMN----AIHSNSLAHLVI---------VIDGSTL--ADIENDPELFLLFINTAVEADSVI 1213

  Fly  1013 CCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAK 1077
            |||.||:||:.:|..::::.|...|.:|||||||::|||||||||||.||||.||||.:||:..:
pombe  1214 CCRSSPMQKALMVQKVRNTLEKAVTLAIGDGANDIAMIQEAHVGIGIAGREGLQAARSSDFSIGR 1278

  Fly  1078 FCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYT 1142
            |..|.:||..||.:..||||..:|..|||...|..:..:.|....::..|:|:|..||.:|.:::
pombe  1279 FKFLIKLLFCHGRWSYVRLSKYILGTFYKEQFFFLMQAIMQPFVGYTGQSLYESWGLTCFNTLFS 1343

  Fly  1143 SLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFF--- 1204
            ||.::.:.|.||..:...::..|:||:|..:|:..:|..:..|...|...:.::||..:..|
pombe  1344 SLCVIGLGIFEKDLSASTVIAVPELYQKGINNEAFNWRVYFGWCSIAFIQAFLVFYVTYSLFGMK 1408

  Fly  1205 -YYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKL-WLESMYLSFWYIFTIIISILGFVVTTVIY 1267
             ..:|.:..|||         |:....:.::|.|| ::|..|::       ||||:..|:|::.:
pombe  1409 ELNDNNIFAYGQ---------LIFTAAIFIMNFKLVFIEMQYIN-------IISIIVLVLTSLAW 1457

  Fly  1268 NVINL----DY-DTDIYWAYNNLL----ASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSI 1323
            .:.|:    .| |.::|.|.:..|    .:...||.::...|..|..|...:||:|.|......|
pombe  1458 FLFNIFISEHYPDKNLYLARSQFLHHFGKNPSWWLTMLFVMVCALTIDIVAQMLRRTLRPTDTDI 1522

  Fly  1324 FPGKQRKLKMREKFE 1338
            |...:....:|.:||
pombe  1523 FVEMENDAFVRSRFE 1537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	393/1522 (26%)
dnf1	NP_001342913.1	P-type_ATPase_APLT_Dnf-like	233..1401	CDD:319770	363/1392 (26%)