DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp11c

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001032952.1	Gene:	Atp11c / 320940	MGIID:	1859661	Length:	1129	Species:	Mus musculus

Alignment Length:	1316	Identity:	432/1316 - (32%)
Similarity:	645/1316 - (49%)	Gaps:	301/1316 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQG 138
            |||.|:||||..|||:||.||||||||||||::.::.:.:|:|.||:||.|||.|||.|||.|||
Mouse    43 NRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVTAIKQG 107

  Fly   139 YEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCF 203
            |||.||:|.||.||.|.|.:|.:.|....:|:.:..|:::.|:.:...||||:||.|....|.|:
Mouse   108 YEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCY 172

  Fly   204 ITTANLDGESNLKTLMVPRDLPTVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGG--EGR 262
            :|||:||||||.||....||  |:.|.....:    ..||||.|..|||.|.|:|.:...  |..
Mouse   173 VTTASLDGESNCKTHYAVRD--TIALCTAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAV 235

  Fly   263 VLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALI 327
            ...|..||:||:|:.:|||:.:.|.||||||.:|:.||.:....|.::.|..||.||||.|..|:
Mouse   236 ARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINAFLIVYLFILL 300

  Fly   328 ---AIVTLLYFL---KRYNELFVIPKLTYLGDAT----DSYSVKQFLQDYLSFLILFNYLIPISL 382
               |:.|.|.::   ..||:      ..:....|    :::.|.:...|:|||::|||::||:|:
Mouse   301 TKAAVCTTLKYVWQSSPYND------EPWYNQKTQKERETFQVLKMFTDFLSFMVLFNFIIPVSM 359

  Fly   383 YVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQC 447
            |||:|:|:.:||:|:.||.:.::.|.::..:||||:|||||||::.:|:|||||||:|.|.|.:|
Mouse   360 YVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIEC 424

  Fly   448 SINGNKFLFKKTRLE----DEETKALLDINKFSAN-QRVFFQALSICHTVQVASGSLEQADAGTA 507
            .|:|:|  :|.|..|    .:....|...:|...| :.:|.:||.:||||
Mouse   425 CIDGHK--YKGTTQEVDGLSQTDGPLAYFDKADKNREALFLRALCLCHTV--------------- 472

  Fly   508 KREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLV 572
                         ||.:..|:
Mouse   473 -------------EMKTNDDV-------------------------------------------- 480

  Fly   573 SDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRR 637
              ||        ||               .||.
Mouse   481 --DG--------PV---------------EGAG-------------------------------- 488

  Fly   638 STSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTF 702

Mouse   489 ----------------------------------------------------------------- 488

  Fly   703 TRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPH 767
                                   ||  |.:|||||.|||:.....|..:.|:.:..:||.
Mouse   489 -----------------------FT--YISSSPDEIALVKGAKRFGFTFLGNQNGYIRVE----- 523

  Fly   768 MDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVT 832
                  ..:...|.::.||.|.|.|.|:|||||||...|...::.|||:|.:||...:...||
Mouse   524 ------NQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHSHQIEL-- 580

  Fly   833 KTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLG 897
             |..|:...|..|.|||.:|.:.|..::::....:|.:|..:|::|::..|:.:.:||:|::|:|
Mouse   581 -TKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIG 644

  Fly   898 ATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFI----MECKN 958
            ||||||.|||..|:|:.:|.|||:|:|||||||:|||.:...:|.....:.:...:    :|...
Mouse   645 ATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESE 709

  Fly   959 REEMLLH--LNALDREIIFGI-------------GQECALLIDGKSLGVALAEA--------SSE 1000
            |:|..||  |....::::...             .||..|:|||.:|.:.|..:        .|.
Mouse   710 RKEDRLHELLIEYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKSI 774

  Fly  1001 FRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGR 1065
            |..:.:|||||||||::||||:::|.::|:...:..|.||||||||||||.|:||||||.|:|||
Mouse   775 FLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGR 839

  Fly  1066 QAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYD 1130
            ||||.:|::..||..||:|||||||.:.||::.||.||||||:.|:...||:||...||...:||
Mouse   840 QAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYD 904

  Fly  1131 SLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVI 1195
            :.:||:||:.:||||||..::.|:....:.|...|:||.|.|.|..|....||.|...|.:...
Mouse   905 AAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGT- 968

  Fly  1196 IFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGF 1260
            :|:|...|.:..:.|.:.|:......|||::...:|..|.|||.|::.:.::...|.|..|:..:
Mouse   969 VFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY 1033

  Fly  1261 VVTTVIYNVINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSI 1323
            |..:..:..|...:  ...:|:.:..:|.|:..||.||:.....|.|:..:.:::   |::..|
Mouse  1034 VFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVVK---NVRRRS- 1094

  Fly  1324 FPGKQRKLKMREKFES 1339
               .:|.|..|...:|
Mouse  1095 ---ARRNLSCRRASDS 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	29/46 (63%)
		ATPase-Plipid	74..1317	CDD:273734	426/1292 (33%)
		E1-E2_ATPase	127..>345	CDD:278548	96/229 (42%)
		Cation_ATPase	<734..823	CDD:289987	32/88 (36%)
		HAD_like	<1036..1066	CDD:304363	23/29 (79%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	84/250 (34%)
Atp11c	NP_001032952.1	P-type_ATPase_APLT_Dnf-like	42..974	CDD:319770	400/1174 (34%)
		Cyt_bd_oxida_II	<993..1083	CDD:376764	23/89 (26%)
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:Q8NB49	1113..1118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835000
Domainoid	1	1.000	168	1.000	Domainoid score	I3810
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	804	1.000	Inparanoid score	I495
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.910