DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp10b

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_795973.2	Gene:	Atp10b / 319767	MGIID:	2442688	Length:	1474	Species:	Mus musculus

Alignment Length:	1391	Identity:	434/1391 - (31%)
Similarity:	672/1391 - (48%)	Gaps:	221/1391 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QDIKK--KRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPV-SPMTSLL 124
            ||.||  :|..| |.|.:|||||:|||||||.|||.|.||.|||.:.|::.:....| ....::.
Mouse    57 QDWKKVCRRYPG-NSICTTKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIF 120

  Fly   125 PLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVI--RDGKEAIIKSQDVIPGELIVVERDCDVP 187
            ||..|:.:...|.|.||..||..|..:||:.:.:.  ::.:..:.:.|||..|:.:.::.:..||
Mouse   121 PLATVLLIIMVKDGIEDFKRYCFDREMNSASIQIYERKEQRYMLKRWQDVRVGDFVQMQCNEIVP 185

  Fly   188 CDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDL--PTVDLPEMHKLGIIECESPTTDLYSF 250
            .|::||.|:||.|.|.:.|||||||:|||...|.:..  |.|.....|....|.||.|...|..|
Mouse   186 ADILLLFSSDPSGVCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEHFHSTIVCEKPNNHLSKF 250

  Fly   251 NGKIE----LKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASS 311
            .|.:|    .:.|.|      :|::||||..::|||...|..:|.|..:|..||:...|.|.:..
Mouse   251 KGYMEHPDQTRTGFG------SESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKI 309

  Fly   312 ETYINRFL-----IVILVALIAIVTLLYFLKRYNE--LFVIPKL--TYLGDATDSYSVKQFLQDY 367
            |..||..:     ::.|:.||..|....:...:.|  .|.:|..  .:|..|...:.:      :
Mouse   310 ERRINTDIFFCIGLLFLMCLIGAVGHSLWNGTFKEHPPFDVPDADGNFLSLALGGFYM------F 368

  Fly   368 LSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSD 432
            |:.:||...||||||||:|||.::...:.:..||:||:.|||........|:.|:||||..:|||
Mouse   369 LTMIILLQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSD 433

  Fly   433 KTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKAL-LDINKFSANQRVFF------------- 483
            ||||||:|:|.|::|:|.|:::..::.....|..|.| .|..:::..|.:.|
Mouse   434 KTGTLTENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRS 498

  Fly   484 ----QALSICHTVQVASGS-LEQADAGTAKREPVTAIKSGPPEMYSIS---DITEESHNASQQSE 540
                |.|..||:.:|...| ..|...|..:       .|.||..:|.|   |:|.:.:..|:..:
Mouse   499 QGGAQPLRRCHSARVPIQSHCRQRSVGRWE-------TSQPPVAFSSSIEKDVTPDKNLLSKVRD 556

  Fly   541 LNVGHTIDNSVSAHPNG---------------VNSTIISSDVNP-----LLVSDDGYGVERRKRP 585
            ..:.....::..|.|:.               .||.::|:...|     ...::...|....|..
Mouse   557 AALWLETSDTRPAKPSHSTTASIADFFLALTICNSVMVSTTTEPRKRVTTPPANKALGTSLEKIQ 621

  Fly   586 VVIKRSPNFARSNRMNNGAASDLNINQT-DPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWE 649
            .:.:|....:.|...::.|.||.::.:: .||.      ||.:           :.|||......
Mouse   622 QLFQRLKLLSLSQSFSSTAPSDTDLGESLGPNL------PTID-----------SDEKDDTSVCS 669

  Fly   650 APSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTS-RESYAAPTFTR-QPTILVRA 712
            .......|:|                 :||...|.:..|.|.|| .|...|||.:: :|
Mouse   670 GDCSTDGGYR-----------------SSTWEQGDILGSESGTSLEEGLEAPTLSQDEP------ 711

  Fly   713 ESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKP 777
                          .|.|:|.||||.|||.|.............|.:.||:             |
Mouse   712 --------------ELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRL-------------P 749

  Fly   778 RE--ETFQRLHVLEFTSDRKRMSVIVRD--TDGKKWIYTKGAESYVFPLCANSSAE--------- 829
            :.  .||..|..|.|.|.||||||:||.  || :..:|||||:|.:..|..:.:.|
Mouse   750 QGICLTFDLLFTLGFDSVRKRMSVVVRHPLTD-EIIVYTKGADSVIMDLLEDPACESNIDVEKKL 813

  Fly   830 --LVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESN 892
              :..:|..|:..:||.|||||.||::::.||::|.:.....:|.:||:||::|..|....:|::
Mouse   814 KRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLENH 878

  Fly   893 LDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECK 957
            |.|||||.:||.||:.|.||:.:|:.|||::|||||||.|||:|||.||..:......|.| ..:
Mouse   879 LTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLLDQTDTVYSI-NTE 942

  Fly   958 NREEMLLHLNALDREI------------IFG--------------IGQECALLIDGKSL-GVALA 995
            |:|.....||....:|            :.|              :..|..|:||||:| .:...
Mouse   943 NQETCESILNCTLEDIKRFHEPQQPARKLCGHRIPPKMPSVNSGAMAPEIGLVIDGKTLNAIFQG 1007

  Fly   996 EASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIM 1060
            :..::|.::...|.:|||||.:|||||.:|.|:: ...:..|.|||||||||||||.|.:||||.
Mouse  1008 KLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVR-DKLSVMTLSIGDGANDVSMIQAADIGIGIS 1071

  Fly  1061 GREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSS 1125
            |:||.||...:|||.|:|..||:|||||||:...||:.:|:|:||||:.::.::|.:||...||.
Mouse  1072 GQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSG 1136

  Fly  1126 SSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAI 1190
            |::.|...:..:|:.:||||.:...:.:|..:.|.|:..|:|||...:::..:.|.|.:.:..|.
Mouse  1137 STMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAF 1201

  Fly  1191 YHSVIIFYFAFCFFYYNNVLLNY-GQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYI---F 1251
            |.|:|.|:..:         |.| |..:....|||.:....:..:.|.   ::|.:..|.:   .
Mouse  1202 YQSLICFFIPY---------LTYRGSDIDVFTFGTPINTISLTTILLH---QAMEMKTWTVLHGL 1254

  Fly  1252 TIIISILGFVVTTVIYNV--INLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQ- 1313
            .::.|.|.:.|.::|||.  :..:..|:.||.....|:....:|..::|.|..|:|.|.:..||
Mouse  1255 VLLGSFLMYFVVSLIYNATCVTCNSPTNPYWVMERQLSDPTFYLICLLTPVVALLPRYFLLSLQG 1319

  Fly  1314 ---RALNIKSFSI--FPGKQRKLKMR 1334
               ::|..|:..|  .|..:|.|:::
Mouse  1320 TYGKSLISKAQKIDKLPIDKRNLEIQ 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	31/60 (52%)
		ATPase-Plipid	74..1317	CDD:273734	422/1357 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	73/232 (31%)
		Cation_ATPase	<734..823	CDD:289987	34/92 (37%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	75/258 (29%)
Atp10b	NP_795973.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..43
		P-type_ATPase_APLT_Dnf-like	68..1211	CDD:319770	396/1232 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..707		23/102 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1348..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.600