DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp11a

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_017455639.1	Gene:	Atp11a / 306600	RGDID:	1308688	Length:	1229	Species:	Rattus norvegicus

Alignment Length:	1378	Identity:	456/1378 - (33%)
Similarity:	671/1378 - (48%)	Gaps:	354/1378 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQ---IQIGGPQDIKKKRPKG-------- 72
            |.||......:|          .|..|.     .:|:.   |.:|     .|:.|.|
  Rat    42 GGHRFEERVPRE----------GWCAGE-----ENWVDSRTIYVG-----HKEPPPGAEAYIPQR 86

  Fly    73 --QNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAA 135
              .|||.|:|||...|:|:||.||||||||||||::.::.|:||:|.||:||.|||.|||.|||.
  Rat    87 YPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLIIDTPTSPVTSGLPLFFVITVTAI 151

  Fly   136 KQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHG 200
            ||||||.||::.|:.:|..||..|:.||....:|:.:..|::::|:.|...||||:.|.|....|
  Rat   152 KQGYEDWLRHKADSAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNRADG 216

  Fly   201 KCFITTANLDGESNLKTLMVPRDL----PTVDLPEMHKLGIIECESPTTDLYSFNGKIELKG--G 259
            .|.:|||:|||||:.||....:|.    ...|:..:|  ..||||.|..|||.|.|:|.:..  .
  Rat   217 TCHVTTASLDGESSHKTHYAVQDTKGFHTEADVDSLH--ATIECEQPQPDLYKFVGRINVYNDLN 279

  Fly   260 EGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIV--- 321
            :..|.||.:||:||||:.:||||.:.|.|:||||.:|:.||.:....|.::.|..:|.||||
  Rat   280 DPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLC 344

  Fly   322 ILVALIAIVTLLYFLKR---------YNELFVIPKLTYLGDATDSYSVKQ-FLQ---DYLSFLIL 373
            |||:...|.|:|.::.:         ||:            .|:|...:. ||:   |:|:|::|
  Rat   345 ILVSKALINTVLKYVWQSEPFRDEPWYNQ------------KTESERQRNLFLRAFTDFLAFMVL 397

  Fly   374 FNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLT 438
            |||:||:|:|||:|:|:.:||:|:.||.::::.|..:..:||||:|||||||:..:|:|||||||
  Rat   398 FNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLT 462

  Fly   439 KNEMNFQQCSINGNKF----LFKKTRLEDEETKALLDINK-FSANQR--VFFQALSICHTVQVAS 496
            :|.|.|::|.|.|:.:    :.....|.|.....::|.:. .|..:|  :||:|:.:||||||
  Rat   463 ENNMAFKECCIEGHVYVPHVICNGQVLPDSSGIDMIDSSPGVSGREREELFFRAICLCHTVQV-- 525

  Fly   497 GSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNST 561
                                             ::.|
  Rat   526 ---------------------------------KDDH---------------------------- 529

  Fly   562 IISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTT 626
                      ..||..|.:
  Rat   530 ----------CGDDVDGPQ---------------------------------------------- 538

  Fly   627 NFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPST 691
                                                                        :||..
  Rat   539 ------------------------------------------------------------KSPDA 543

  Fly   692 TSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDD 756
            .|                                  ..|.:|||||.||||....||..|
  Rat   544 KS----------------------------------CVYISSSPDEVALVEGMQRLGFTY----- 569

  Fly   757 ETLRVRIVPPHMDYKRPFAKPRE---ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESY 818
                :|:...:|:...     ||   |.|:.|.||.|.|.|:||||||:.|.|:.:::.|||:|.
  Rat   570 ----LRLKDNYMEILN-----RENDIERFELLEVLTFDSVRRRMSVIVKSTTGEIYLFCKGADSS 625

  Fly   819 VFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSE 883
            :||.......:.|.   :.:...|..|||||.:|.:.:..|:|:|....|..|..:|::|::...
  Rat   626 IFPRVIEGKVDQVR---SRVERNAVEGLRTLCVAYKRLEPEQYEDACRLLQDAKVALQDREKKLA 687

  Fly   884 ECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDA 948
            |.|.:||.:|.|||||||||.||:..|||:.:||.||||:|||||||:|||.....:|
  Rat   688 EAYEQIEKDLILLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYAC------- 745

  Fly   949 KKYF-----IME--CKNREEMLLH-------------LNALDREIIFGIG---QECALLIDGKSL 990
             |.|     ::|  .|..||..||             ..:|.|:...|:.   .:..|:|||.:|
  Rat   746 -KLFRRSTQLLELTTKKLEEQSLHDVLFELSKTVLRCSGSLTRDSFSGLSTDMHDYGLIIDGAAL 809

  Fly   991 GVAL-----AEASSEFRDVAVK----CTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGAND 1046
            .:.:     ..:|..:|::.::    |:||||||::||||:::|.|||.|.|:..|.:|||||||
  Rat   810 SLIMKPREDGSSSGNYRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEHPITLAIGDGAND 874

  Fly  1047 VSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFM 1111
            ||||.|||||||::|:|||||||.:|:|..||..||::||||||::.:|:|.||.||||||:.|:
  Rat   875 VSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFI 939

  Fly  1112 GIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQ 1176
            ...||:||...||..::||:.:|||||:.:||||||..::.|:....:.|.|.|.||:....|..
  Rat   940 FPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPSLYRDIAKNAL 1004

  Fly  1177 LHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLE 1241
            |.|..|:.|....::.:::.|:.|:..|....|.:| ||......||||:...:|..|.|||.|:
  Rat  1005 LRWRLFIYWTFLGVFDALVFFFGAYFMFENTTVTIN-GQMFGNWTFGTLVFTVMVFTVTLKLALD 1068

  Fly  1242 SMYLSFWYIFTIIISILGFVVTTVIYNVI---NLDYDTDIYWAYNNLLASLPVWLWIIVTCVACL 1303
            :.|.::...|.|..|:|.::|.::::..|   .|.|.. :|:.:..:|:|.|.||.||:.....|
  Rat  1069 THYWTWINHFVIWGSLLFYIVFSLLWGGIIWPFLSYQR-MYYVFIYMLSSGPAWLGIILLVTVGL 1132

  Fly  1304 VPDYTIRMLQRAL 1316
            :||...::|.|.|
  Rat  1133 LPDVLKKVLCRQL 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	34/73 (47%)
		ATPase-Plipid	74..1317	CDD:273734	444/1310 (34%)
		E1-E2_ATPase	127..>345	CDD:278548	94/235 (40%)
		Cation_ATPase	<734..823	CDD:289987	37/91 (41%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	95/252 (38%)
Atp11a	XP_017455639.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338594
Domainoid	1	1.000	169	1.000	Domainoid score	I3703
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	743	1.000	Inparanoid score	I560
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.910