DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp8b3

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_234937.3	Gene:	Atp8b3 / 299616	RGDID:	1307622	Length:	1340	Species:	Rattus norvegicus

Alignment Length:	1427	Identity:	372/1427 - (26%)
Similarity:	616/1427 - (43%)	Gaps:	394/1427 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AHRQTPWADQESFHLKDAFLWN-------WHKGSRVSTINDWLQIQIGGPQDIKKKRPKGQNRIK 77
            ||.:....|:::     .|.|.       :||..|......|.|         ||.:   .|.|.
  Rat     4 AHLEEDLEDKDT-----EFTWEVKANDRAYHKQFRKKGFLCWRQ---------KKYK---SNAIH 51

  Fly    78 STKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSP-MTSLLPLVFVIAVTAAKQGYED 141
            :.||.:.:|||.||.|||||::|.|||.:.|:..:.:....| .|...|||.::.:.||:...:|
  Rat    52 TAKYNVFSFLPLNLYEQFRRVSNLYFLFIIILQSIPEISTLPWFTLFAPLVCLLMIRAARDLVDD 116

  Fly   142 ILRYRTDNVVNSSPVTVIRDGKEAIIKS-QDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFIT 205
            |.|:|:|.::|:.|..::: ||..:.|. :::..|:::.:.:|..||.||:||.||:|...|::.
  Rat   117 IGRHRSDRIINNRPCQILK-GKSFLWKKWKNLCVGDVVCLSKDNIVPADLLLLASTEPSSLCYLE 180

  Fly   206 TANLDGESNLK---TLMVPRDLPTVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRV 263
            ||::|||:|||   .|||...    :|....|:    ||:.||.|.:.::.|.|.:|   ...|.
  Rat   181 TADIDGETNLKFRQALMVTHH----ELTSPKKMASFQGIVTCEEPNSRMHHFVGSLE---WNSRK 238

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIA 328
            .||...|:||||.:::||:...|..:|.|:.:|:..|......|....:..:|:.:|:|.::|:.
  Rat   239 YPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKNCGKIHLKRTKLDLMMNKLVILIFMSLVI 303

  Fly   329 IVTLL-----YFLKRYNELFVIPKLTYLG------DATDSYSVKQFLQDYLSFLILFNYLIPISL 382
            ....|     :.:|.:.     .|..|:.      ||.||:.:      :..||||.:.::|:::
  Rat   304 ASMFLTLGFAFMVKEFK-----AKHHYMSSMQGRTDAMDSFFI------FWGFLILLSVMVPMAM 357

  Fly   383 YVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQC 447
            ::..|...:..|.|:.|||.:|....|.|....:::||:.|||:..:|||||||||:|.|.|::|
  Rat   358 FIIAEFIYLGNSIFINWDLSMYYEPLDIPAKARSTSLNDHLGQVQYIFSDKTGTLTQNIMTFKKC 422

  Fly   448 SINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPV 512
            .|||                                     |
  Rat   423 CING-------------------------------------C----------------------- 427

  Fly   513 TAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGY 577
                                             |.|                        |||.:
  Rat   428 ---------------------------------TYD------------------------SDDEH 435

  Fly   578 GVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEK 642
            |..|::.|.                           ..|...:|          .|||    ..|
  Rat   436 GTLRKRNPY---------------------------SWNPFADG----------KLQF----YNK 459

  Fly   643 DLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPT 707
            :|:.                                      |.|     .::..|...|.|...
  Rat   460 ELES--------------------------------------LVR-----GKQDRAVQEFWRLLA 481

  Fly   708 ILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKR 772
            |......|.:.|:       |.|||:||||:|||.|..|.|.|:.....:|:.:
  Rat   482 ICHTVMVQEKDNQ-------LLYQAASPDEEALVAAARNFGYVFLSRTQDTITL----------- 528

  Fly   773 PFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAH 837
             .....|..:|.|.:::|.|.||||||:||:.:|...:|||||::.:.....:......| |:..
  Rat   529 -VELGEERVYQVLAMMDFNSVRKRMSVLVRNPEGSICLYTKGADTVILERLHHKGVMEAT-TEEV 591

  Fly   838 ISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVE 902
            ::.||...||||.:|.:.::|:.|:::..|..:|...|:||.|...:.|.|:|.||.|||.||:|
  Rat   592 LAAFAEQTLRTLCLAYKDVAEDAYKEWEPEHQEAALLLQNRAQALHQVYNKLEQNLQLLGVTAIE 656

  Fly   903 DALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKN--------- 958
            |.|||.|.:|:..|:...||:|||||||.|||:||..:|..:   ::...|:|.|:
  Rat   657 DKLQDGVPETIRCLKKGNIKMWVLTGDKPETAVNIGFACQLL---SENMSILEDKDIKGLLENYW 718

  Fly   959 -------------REEMLLHLNA--LDREIIFGIGQECALLIDG--------------------- 987
                         ...|.|.:|.  || :::..:.:|...|:..
  Rat   719 DENEHQRAFQTMTHHNMALVINGEFLD-QLLLSLRKEPRALVQNAVVDEATQEPGVSALDFLQAR 782

  Fly   988 ------KSLGVALAEASSE---------------FRDVAVKCTAVLCCRLSPLQKSEVVSLIKSS 1031
                  ::.|..:|.:.|:               |.|:|.||.||:|||::|.||:.||:|:| .
  Rat   783 RISQMWRNFGTTMATSQSDASKTRESPEERRERAFVDLASKCQAVICCRVTPKQKALVVALVK-K 846

  Fly  1032 NENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRL 1096
            .:...|.:||||||||:||:.|.:|:|:.|:||.||.:.:|:..|:||.|:|||||||.:..:|:
  Rat   847 YQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLAQFCYLQRLLLVHGRWSYMRI 911

  Fly  1097 SLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKL 1161
            ...:.|||||.:..|.....|.....||:..:|:..||.|:|::|::||:|:|.:.|:..|.||.
  Rat   912 CKFLRYFFYKTVASMMAQIWFSLFNGFSAQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVTAEKS 976

  Fly  1162 MRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNY-----GQTVAFSC 1221
            ::.|:||.....::..::..|:.    ||.|..|.....|    :..:|::|     |.:..:..
  Rat   977 LKMPELYTAGQKDELFNYSIFVQ----AIAHGTITSLINF----FVTILVSYDMTKTGSSPDYQS 1033

  Fly  1222 FGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINL-------------D 1273
            ||.|:..:.::.:.|::.|...|.:..::.|:::|:..:|:.|.:...:.|             |
  Rat  1034 FGVLVAISSLLSITLEVILVVKYWTLLFVGTVVVSLSSYVIFTSLTESLLLFRISPKTFPFLFAD 1098

  Fly  1274 YDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMRE 1335
            |         |::......|.|::......:|...:|:::|.:    ....|.|:.::...|
  Rat  1099 Y---------NVIREPSSLLVIVLNVTLNTLPMLAVRIIRRTV----LKRHPKKEEEVPSEE 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	22/64 (34%)
		ATPase-Plipid	74..1317	CDD:273734	357/1346 (27%)
		E1-E2_ATPase	127..>345	CDD:278548	68/230 (30%)
		Cation_ATPase	<734..823	CDD:289987	31/88 (35%)
		HAD_like	<1036..1066	CDD:304363	17/29 (59%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	67/266 (25%)
Atp8b3	XP_234937.3	PhoLip_ATPase_N	20..96	CDD:292826	27/87 (31%)
		ATPase-Plipid	45..1143	CDD:273734	359/1366 (26%)
		Cation_ATPase	483..577	CDD:289987	37/112 (33%)
		COG4087	<839..890	CDD:226572	24/51 (47%)
		PhoLip_ATPase_C	883..1131	CDD:292829	66/264 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338607
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750