Protein Alignment CG4301 and Atp8b3

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_001419373.1
• Gene: Atp8b3 / 299616
• RGDID: 1307622
• Length: 1340
• Species: Rattus norvegicus
• Alignment Length: 1427
• Identity: 372/1427 - (26%)
• Similarity: 616/1427 - (43%)
• Gaps: 394/1427 - (27%)

  Fly    20 AHRQTPWADQESFHLKDAFLWN-------WHKGSRVSTINDWLQIQIGGPQDIKKKRPKGQNRIK 77
            ||.:....|:::     .|.|.       :||..|......|.|         ||.:   .|.|.
  Rat     4 AHLEEDLEDKDT-----EFTWEVKANDRAYHKQFRKKGFLCWRQ---------KKYK---SNAIH 51

  Fly    78 STKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSP-MTSLLPLVFVIAVTAAKQGYED 141
            :.||.:.:|||.||.|||||::|.|||.:.|:..:.:....| .|...|||.::.:.||:...:|
  Rat    52 TAKYNVFSFLPLNLYEQFRRVSNLYFLFIIILQSIPEISTLPWFTLFAPLVCLLMIRAARDLVDD 116

  Fly   142 ILRYRTDNVVNSSPVTVIRDGKEAIIKS-QDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFIT 205
            |.|:|:|.::|:.|..::: ||..:.|. :::..|:::.:.:|..||.||:||.||:|...|::.
  Rat   117 IGRHRSDRIINNRPCQILK-GKSFLWKKWKNLCVGDVVCLSKDNIVPADLLLLASTEPSSLCYLE 180

  Fly   206 TANLDGESNLK---TLMVPRDLPTVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRV 263
            ||::|||:|||   .|||...    :|....|:    ||:.||.|.:.::.|.|.:|   ...|.
  Rat   181 TADIDGETNLKFRQALMVTHH----ELTSPKKMASFQGIVTCEEPNSRMHHFVGSLE---WNSRK 238

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIA 328
            .||...|:||||.:::||:...|..:|.|:.:|:..|......|....:..:|:.:|:|.::|:.
  Rat   239 YPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKNCGKIHLKRTKLDLMMNKLVILIFMSLVI 303

  Fly   329 IVTLL-----YFLKRYNELFVIPKLTYLG------DATDSYSVKQFLQDYLSFLILFNYLIPISL 382
            ....|     :.:|.:.     .|..|:.      ||.||:.:      :..||||.:.::|:::
  Rat   304 ASMFLTLGFAFMVKEFK-----AKHHYMSSMQGRTDAMDSFFI------FWGFLILLSVMVPMAM 357

  Fly   383 YVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQC 447
            ::..|...:..|.|:.|||.:|....|.|....:::||:.|||:..:|||||||||:|.|.|::|
  Rat   358 FIIAEFIYLGNSIFINWDLSMYYEPLDIPAKARSTSLNDHLGQVQYIFSDKTGTLTQNIMTFKKC 422

  Fly   448 SINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPV 512
            .|||                                     |
  Rat   423 CING-------------------------------------C----------------------- 427

  Fly   513 TAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGY 577
                                             |.|                        |||.:
  Rat   428 ---------------------------------TYD------------------------SDDEH 435

  Fly   578 GVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEK 642
            |..|::.|.                           ..|...:|          .|||    ..|
  Rat   436 GTLRKRNPY---------------------------SWNPFADG----------KLQF----YNK 459

  Fly   643 DLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPT 707
            :|:.                                      |.|     .::..|...|.|...
  Rat   460 ELES--------------------------------------LVR-----GKQDRAVQEFWRLLA 481

  Fly   708 ILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKR 772
            |......|.:.|:       |.|||:||||:|||.|..|.|.|:.....:|:.:
  Rat   482 ICHTVMVQEKDNQ-------LLYQAASPDEEALVAAARNFGYVFLSRTQDTITL----------- 528

  Fly   773 PFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAH 837
             .....|..:|.|.:::|.|.||||||:||:.:|...:|||||::.:.....:......| |:..
  Rat   529 -VELGEERVYQVLAMMDFNSVRKRMSVLVRNPEGSICLYTKGADTVILERLHHKGVMEAT-TEEV 591

  Fly   838 ISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVE 902
            ::.||...||||.:|.:.::|:.|:::..|..:|...|:||.|...:.|.|:|.||.|||.||:|
  Rat   592 LAAFAEQTLRTLCLAYKDVAEDAYKEWEPEHQEAALLLQNRAQALHQVYNKLEQNLQLLGVTAIE 656

  Fly   903 DALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKN--------- 958
            |.|||.|.:|:..|:...||:|||||||.|||:||..:|..:   ::...|:|.|:
  Rat   657 DKLQDGVPETIRCLKKGNIKMWVLTGDKPETAVNIGFACQLL---SENMSILEDKDIKGLLENYW 718

  Fly   959 -------------REEMLLHLNA--LDREIIFGIGQECALLIDG--------------------- 987
                         ...|.|.:|.  || :::..:.:|...|:..
  Rat   719 DENEHQRAFQTMTHHNMALVINGEFLD-QLLLSLRKEPRALVQNAVVDEATQEPGVSALDFLQAR 782

  Fly   988 ------KSLGVALAEASSE---------------FRDVAVKCTAVLCCRLSPLQKSEVVSLIKSS 1031
                  ::.|..:|.:.|:               |.|:|.||.||:|||::|.||:.||:|:| .
  Rat   783 RISQMWRNFGTTMATSQSDASKTRESPEERRERAFVDLASKCQAVICCRVTPKQKALVVALVK-K 846

  Fly  1032 NENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRL 1096
            .:...|.:||||||||:||:.|.:|:|:.|:||.||.:.:|:..|:||.|:|||||||.:..:|:
  Rat   847 YQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLAQFCYLQRLLLVHGRWSYMRI 911

  Fly  1097 SLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKL 1161
            ...:.|||||.:..|.....|.....||:..:|:..||.|:|::|::||:|:|.:.|:..|.||.
  Rat   912 CKFLRYFFYKTVASMMAQIWFSLFNGFSAQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVTAEKS 976

  Fly  1162 MRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNY-----GQTVAFSC 1221
            ::.|:||.....::..::..|:.    ||.|..|.....|    :..:|::|     |.:..:..
  Rat   977 LKMPELYTAGQKDELFNYSIFVQ----AIAHGTITSLINF----FVTILVSYDMTKTGSSPDYQS 1033

  Fly  1222 FGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINL-------------D 1273
            ||.|:..:.::.:.|::.|...|.:..::.|:::|:..:|:.|.:...:.|             |
  Rat  1034 FGVLVAISSLLSITLEVILVVKYWTLLFVGTVVVSLSSYVIFTSLTESLLLFRISPKTFPFLFAD 1098

  Fly  1274 YDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMRE 1335
            |         |::......|.|::......:|...:|:::|.:    ....|.|:.::...|
  Rat  1099 Y---------NVIREPSSLLVIVLNVTLNTLPMLAVRIIRRTV----LKRHPKKEEEVPSEE 1147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	357/1346 (27%)
Atp8b3	NP_001419373.1	P-type_ATPase_APLT_Dnf-like	47..1015	CDD:319770	335/1220 (27%)