DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and CG33298

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_995666.1	Gene:	CG33298 / 2768929	FlyBaseID:	FBgn0032120	Length:	1517	Species:	Drosophila melanogaster

Alignment Length:	1450	Identity:	457/1450 - (31%)
Similarity:	721/1450 - (49%)	Gaps:	268/1450 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GHDHLSGFRRIDRLGAHRQT---PWADQESFHLKDAFLWNWHKGSRVS-----------TINDWL 55
            |..|.....|.:.:...|:|   ||       .|...|.|::.|.:..           |:
  Fly   183 GRGHSRQASRSESIYTLRRTEAPPW-------WKRLTLCNYNTGDKFEERSYRTVVPNHTV---- 236

  Fly    56 QIQIGGPQDIKKKRPKGQ---NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SP 116
                 .|:..|:..|.||   |:|::|||||::|:|:||||||.|:||.||:.:.:::.:.: |.
  Fly   237 -----PPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISA 296

  Fly   117 VSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDG---KEAIIKSQDVIPGELI 178
            .....:::|::||:.|||.|..:||..|..:|..:|::...|. ||   :...:|.|::..|:::
  Fly   297 FGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVY-DGETERYKKVKWQELRVGDIV 360

  Fly   179 VVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPR---DLPTVDLPEMHKLGIIEC 240
            .:..:..||.|::|||::||.|.|:|.|.:||||:|||...|.|   ::.::.:|... :..:|.
  Fly   361 HLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKF-VSRVEA 424

  Fly   241 ESPTTDLYSFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTR 305
            ::|||.||.|:|.:....|| || |:|||.:|||.||:|||:.:.|..||.|..:|..||:...|
  Fly   425 DAPTTKLYRFHGALIHPTGE-RV-PISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPR 487

  Fly   306 NKNASSETYINRFLI--VILVALIAIVTLL---YFLKRYNELFVIP-----KLTYLGDATDSYSV 360
            .|.:..|..:|..:|  ||::.::.:|..:   .:|..:.. |.:|     |||         :.
  Fly   488 YKRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFTH-FPVPYLPPNKLT---------AN 542

  Fly   361 KQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQ 425
            .:.:..:.:::::...:||:||||||||.:::..:.:..:::|::.||::.......|:.|||||
  Fly   543 MESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQ 607

  Fly   426 INILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETK------ALLDINKFSAN------ 478
            |..:|:|||||||:|:|.|::|.:||:.:....:.||...:|      .|:..:..:::
  Fly   608 IQHIFTDKTGTLTENKMIFRRCVVNGSDYNHPPSELEKIYSKPGAPAPPLIPNDNLNSDMAQLTQ 672

  Fly   479 --------QRV--FFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESH 533
                    ||:  |...|:||:||.|  |:....|...|         ||..|:..|.:......
  Fly   673 GTYLTPHAQRIQEFLVVLAICNTVIV--GAAPHRDMMNA---------SGIIEVQQIGNSPANLK 726

  Fly   534 NASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVS--DDGYGVERRKRPVVIKRSPNF-- 594
            :..|:.:|....|...:.:...||..:       .|.:||  .|.|......|.|.....||.
  Fly   727 HGKQRQKLLASSTSTTTTTTIINGPTT-------QPQVVSIPADRYIRLAESRSVTPSPPPNLLF 784

  Fly   595 ---ARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAP 656
               |:|:                        :||.:  |||     |::|.......|:||   |
  Fly   785 ALPAQSH------------------------QPTLS--PIS-----SSAESSPNSESESPS---P 815

  Fly   657 GHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRK--- 718
            ..:        |..|:|.::    |.|   |:.:..:.:..:..||....|     :.:|.|
  Fly   816 PMK--------NKSLSNSIS----PTG---RAKAVINSKITSIATFLNAKT-----QGKRMKLPS 860

  Fly   719 NEIRDFIFTLD----YQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPRE 779
            ::......|.|    |:|.||||.|||.|      .|:.|   ...:...|..:....|.|....
  Fly   861 SKTGTIYRTADGRPLYEAESPDELALVNA------AYSYD---CCLLNRSPNQILVSMPMAGATR 916

  Fly   780 ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWI-YTKGAESYVFPL---CANSSAE--LVTKTDAHI 838
            | ::.|.||.|.|.||.||::||....::.: |||||:|.:.|:   |:::|.|  |..:|...:
  Fly   917 E-YEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLL 980

  Fly   839 SDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVED 903
            ..:||.|||.|.:|:|.::..:|.|:.....:...|||||::...:.:||:||||.|||||.:||
  Fly   981 DRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIED 1045

  Fly   904 ALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNA 968
            .|||.|.:|:.||.:|||.:|||||||.|||:|||.|.        |.|..:.:     |:.|.|
  Fly  1046 RLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSA--------KLFTQQME-----LIRLTA 1097

  Fly   969 LDREI-------------------IFGIGQ-----ECALLIDGKSLGVALAEASS---EFRDVAV 1006
            ..|:.                   ..|.||     :.||::|||:|...|...|.   .|..::.
  Fly  1098 RSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQRALVVDGKTLTFILDPKSKLILPFLRLSK 1162

  Fly  1007 KCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCA 1071
            :|.:|||||.:||||:.:|.::| ...|..|.:||||||||||||.|.||:||.|:||.||...|
  Fly  1163 RCASVLCCRSTPLQKAYLVKVVK-EELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAA 1226

  Fly  1072 DFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTL 1136
            ||...:|..|:||||.||::...|||.::|||||||..|:.::|.:|.:..||...:.|.::|.|
  Fly  1227 DFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLML 1291

  Fly  1137 YNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPY----FLMWVLFAIYHSVIIF 1197
            ||:|:||||.|.|.:.:|...|:.|::.|.|||    |.:|...|    |.:.:|.|:|.|::||
  Fly  1292 YNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYK----NGRLGVAYRPHDFWLILLDALYQSLVIF 1352

  Fly  1198 YFAFCFFYYNNV-LLNYGQTVAFSC-FGTLL-------MWTVVVVVNLKLWLESMYLSFWYIFTI 1253
            :.|.|.:..::| :..:|.|:..|| |..|:       .|||:.|:::.|.|.|.||     |.|
  Fly  1353 FVALCAYAESDVGIWEFGTTITASCLFANLVHCAIEIRSWTVLHVLSIVLSLGSFYL-----FAI 1412

  Fly  1254 IISILGFVVTTVIYNVINLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNI 1318
                   |..:|..|...:   ...||......||...||.|:::.|..::|    |:|...:.|
  Fly  1413 -------VYDSVCMNCFGV---RSSYWVIFVCFASAVHWLVIMLSTVVAVLP----RLLLTTVRI 1463

  Fly  1319 KSFSIFPGKQRKLKMREKFE 1338
               |:.|....|:.::.|.|
  Fly  1464 ---SLCPDDSTKVILQSKRE 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	26/67 (39%)
		ATPase-Plipid	74..1317	CDD:273734	434/1341 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	80/228 (35%)
		Cation_ATPase	<734..823	CDD:289987	32/92 (35%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	89/261 (34%)
CG33298	NP_995666.1	PhoLip_ATPase_N	249..299	CDD:292826	22/49 (45%)
		ATPase-Plipid	250..1473	CDD:273734	437/1358 (32%)
		E1-E2_ATPase	302..>394	CDD:278548	32/92 (35%)
		Cation_ATPase	<880..965	CDD:289987	33/94 (35%)
		HAD_like	<1177..1240	CDD:304363	33/63 (52%)
		PhoLip_ATPase_C	1223..1468	CDD:292829	91/270 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14244
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	1	1.100	-	-	P	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.700