DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp13a5

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_783581.2	Gene:	Atp13a5 / 268878	MGIID:	2444068	Length:	1216	Species:	Mus musculus

Alignment Length:	1371	Identity:	246/1371 - (17%)
Similarity:	438/1371 - (31%)	Gaps:	528/1371 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 YTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRY 145
            :||..:|.|..:|.     :...:::|:||:                 |::|...:|  :.:..:
Mouse   213 FTLTLWLSQGYIEY-----SVAIIILTVISI-----------------VLSVYDLRQ--QSVKLH 253

  Fly   146 RTDNVVNSSPVTV-IRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANL 209
            :.....|...||: :||.....::|:.::||:::::.....:|||.:|:     .|.|.:....|
Mouse   254 KLVEEHNKVQVTITVRDKGLQELESRLLVPGDILILPGKISLPCDAILI-----DGSCVVNEGML 313

  Fly   210 DGESNLKTLMVPRDLPTVDLPEMHKLGIIECESPTTDLYS----FNGK--IELK-GGEG--RVLP 265
            .|||          :|....|.......:..:|.:.:.|.    |.|.  |::| ..:|  |.:.
Mouse   314 TGES----------IPVTKTPLPQTENTMPWKSHSLEDYRKHVLFCGTEVIQVKPSAQGLVRAVV 368

  Fly   266 LSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIV 330
            |.|.....:|..|::            ::....||.:|          |.:.|..::.:|.:.:|
Mouse   369 LQTGYNTAKGDLVRS------------ILYPRPLNFKL----------YNDAFKFMVFLACVGVV 411

  Fly   331 TLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSW 395
            ...|.|..|....|.|:.|    ||.:             |||.:..:|..|...:    .||:.
Mouse   412 GFFYALGVYMYHEVPPRET----ATMA-------------LILLSATVPPVLPAAL----TIGNV 455

  Fly   396 FMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMN-FQQCSINGNKFLFKKT 459
            :.:..|:..:.....|..:|.      .||||::..|||||||::.:: :......||.|
Mouse   456 YAQKRLKKEKIFCISPQRINM------CGQINLVCFDKTGTLTEDGLDLWGTVPTAGNCF----- 509

  Fly   460 RLEDEETKALLDINKFSANQRV----FFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPP 520
                      ..::.|::.:.|    ...|::.||::.:..|:::
Mouse   510 ----------QAVHSFASGEAVPWGPLCAAMTSCHSLILLDGTIQ-------------------- 544

  Fly   521 EMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRP 585
                                   |..:|                      |...:|.|.
Mouse   545 -----------------------GDPLD----------------------LKMFEGTGW------ 558

  Fly   586 VVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEA 650
                         .|.:...:.......|.:||..
Mouse   559 -------------NMEDSQVASCKFGMADSSTVIK------------------------------ 580

  Fly   651 PSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQ 715
                 ||.:.:.|          ||.:.|    :|.:.|
Mouse   581 -----PGPKASQS----------PVDSIT----ILRQFP-------------------------- 600

  Fly   716 RRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE 780

Mouse   601 ----------------------------------------------------------------- 600

  Fly   781 TFQRLHVLEFTSDRKRMSVIVR-DTDGKKWIYTKGAESYVFPLCANSSAELVTKT-DAHISDFAR 843
                     |:|..:|||||.: ..|....:|.|||...|...|   .:|.|.|. ...:.::..
Mouse   601 ---------FSSGLQRMSVIAQLAGDLHLHVYMKGAPEMVARFC---RSETVPKNFSQELRNYTV 653

  Fly   844 LGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDD 908
            .|.|.:|:|.:.:..|...|.              ..|:.|   |:||.|..||...:|:.|:.:
Mouse   654 QGFRVIALAHKTLKMERLSDM--------------DHLARE---KVESELAFLGLLIMENRLKKE 701

  Fly   909 VADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEML---------- 963
            ....|..|..|.|:..::|||.::||:.:|.:...||. ..:..|:|.....:::
Mouse   702 TRPVLKELSEARIRTVMVTGDNLQTAITVAKNSEMIPV-GSQVVIVEANEPGDLVPASVTWQLVG 765

  Fly   964 ----------LHLNALDREIIFGIGQECALLIDGKSLGVALAEASSEFRDVAVKCTAVLCCRLSP 1018
                      .:::..:..:..|.|...|:  .|||..|......|....:.|..|  :..|:||
Mouse   766 TQEPGSGKKDTYIDIGNSSVPAGKGYHFAM--SGKSYQVLFHHFYSMLPQILVNGT--IFARMSP 826

  Fly  1019 LQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGI-----------------------M 1060
            .|||.:|.  :....||.....||||||...::.||.||.:                       :
Mouse   827 GQKSSLVE--EFQKLNYYVGMCGDGANDCGALKMAHAGISLSEQEASVASPFTSKTANIECVPHL 889

  Fly  1061 GREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSS 1125
            .|||| ||..:.|...|:      |.::|....:..|||    :::..:|....:|.|
Mouse   890 IREGR-AALVSSFGVFKY------LTMYGIIQFIGTSLL----YWQLQLFGNYQYLLQ------- 936

  Fly  1126 SSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDN---------------K 1175
             .|..:|.::|...|..:.|.|      .||.....:.:|||......|               |
Mouse   937 -DVAITLMVSLTMSINHAYPKL------APYRPAGQLLSPQLLLSVFMNSCFTCIVQVCTFLTVK 994

  Fly  1176 QLHWPYFLMWVLFAIYHSVIIFYFAFCFF---------------YYNNVLLNYGQTVAFSCFGTL 1225
            |..|           |..|  :.::.||.               :..|..|.....::|.  ||.
Mouse   995 QQPW-----------YCEV--YKYSECFLVNQSNLSANVSLDRNWTGNATLVPASVLSFE--GTT 1044

  Fly  1226 LMWTVV---------VVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDIY-- 1279
            | |.:|         :....|.:.:.:|.:  |:|:::::....:...:::    .|:. |:|
Mouse  1045 L-WPIVTFNCISAAFIFSKGKPFRKPIYAN--YLFSLLLASAAGLTIFILF----CDFQ-DLYRK 1101

  Fly  1280 ---------WAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNI-KSFSIFPGKQRKLKMR 1334
                     |..:.|:|:      .:..|||..|.|..::..:..|.| |.|..:...|.::..|
Mouse  1102 MEFIPTPTSWRVSILIAA------FVQFCVAFFVEDAVLQNRELWLFIKKEFGFYSKSQYRILQR 1160

  Fly  1335 EKFEST 1340
            :..|.:
Mouse  1161 KLAEDS 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	8/39 (21%)
		ATPase-Plipid	74..1317	CDD:273734	239/1345 (18%)
		E1-E2_ATPase	127..>345	CDD:278548	45/227 (20%)
		Cation_ATPase	<734..823	CDD:289987	13/89 (15%)
		HAD_like	<1036..1066	CDD:304363	13/52 (25%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	53/298 (18%)
Atp13a5	NP_783581.2	P5-ATPase	23..137	CDD:289194
		P-ATPase-V	24..1118	CDD:273738	233/1315 (18%)
		Cation_ATPase_N	<170..239	CDD:279080	8/47 (17%)
		E1-E2_ATPase	228..471	CDD:278548	61/319 (19%)
		Cation_ATPase	<594..637	CDD:289987	17/149 (11%)
		HAD_like	<823..873	CDD:304363	19/51 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000