DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP11A

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_005268356.1	Gene:	ATP11A / 23250	HGNCID:	13552	Length:	1192	Species:	Homo sapiens

Alignment Length:	1321	Identity:	447/1321 - (33%)
Similarity:	665/1321 - (50%)	Gaps:	320/1321 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 GGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLL 124
            |....|.::.|  .|||.|:|||...|:|:||.|||||:||||||::.::.|:||:|.||:||.|
Human    36 GAEAYIPQRYP--DNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGL 98

  Fly   125 PLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCD 189
            ||.|||.|||.||||||.||::.||.:|..||..|:.||....:|:.:..|::::|:.|...|||
Human    99 PLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCD 163

  Fly   190 LVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDL----PTVDLPEMHKLGIIECESPTTDLYSF 250
            |:.|.|....|.|.:|||:|||||:.||....:|.    ...|:..:|  ..||||.|..|||.|
Human   164 LIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLH--ATIECEQPQPDLYKF 226

  Fly   251 NGKIELKG--GEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSET 313
            .|:|.:..  .:..|.||.:||:||||:.:||||.:.|.|:||||.:|:.||.:....|.::.|.
Human   227 VGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEK 291

  Fly   314 YINRFLIVILVALIA---IVTLLYFLKR---------YNELFVIPKLTYLGDATDSYSVKQ-FLQ 365
            .:|.||||.|..||:   |.|:|.::.:         ||:            .|:|...:. ||:
Human   292 SMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQ------------KTESERQRNLFLK 344

  Fly   366 ---DYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQIN 427
               |:|:|::||||:||:|:|||:|:|:.:||:|:.||.::::.||.:..:||||:|||||||:.
Human   345 AFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVE 409

  Fly   428 ILFSDKTGTLTKNEMNFQQCSINGNKF----LFKKTRLEDEETKALLDINKFSANQR----VFFQ 484
            .:|:|||||||:|.|.|::|.|.|:.:    :.....|.:.....::|.:. |.|.|    :||:
Human   410 YIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSP-SVNGREREELFFR 473

  Fly   485 ALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDN 549
            ||.:||||||..                                                   |:
Human   474 ALCLCHTVQVKD---------------------------------------------------DD 487

  Fly   550 SVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTD 614
            ||                       ||        |   ::||:..:|
Human   488 SV-----------------------DG--------P---RKSPDGGKS----------------- 501

  Fly   615 PNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTAST 679

Human   502 ----------------------------------------------------------------- 501

  Fly   680 PPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEAC 744
                                                            ..|.:|||||.||||..
Human   502 ------------------------------------------------CVYISSSPDEVALVEGV 518

  Fly   745 ANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKW 809
            ..||..|....|..:.:.....|:           |.|:.|.:|.|.|.|:||||||:...|:.:
Human   519 QRLGFTYLRLKDNYMEILNRENHI-----------ERFELLEILSFDSVRRRMSVIVKSATGEIY 572

  Fly   810 IYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSS 874
            ::.|||:|.:||.......:.:.   |.:...|..|||||.:|.:.:.:|||:.....|..|..:
Human   573 LFCKGADSSIFPRVIEGKVDQIR---ARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVA 634

  Fly   875 LENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIAL 939
            |::|::...|.|.:||.:|.|||||||||.||:..|||:.:||.||||:|||||||:|||.....
Human   635 LQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCY 699

  Fly   940 SCGHIPPDAKKYF-----IME--CKNREE-------------MLLHLNALDREIIFGIG---QEC 981
            :|        |.|     ::|  .|..||             :|.|..:|.|:.:.|:.   |:.
Human   700 AC--------KLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDY 756

  Fly   982 ALLIDGKSLGVALAE----ASSEFRDVAVK----CTAVLCCRLSPLQKSEVVSLIKSSNENYNTA 1038
            .|:|||.:|.:.:..    :|..:|::.::    |:||||||::||||:::|.|||.|.|:..|.
Human   757 GLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITL 821

  Fly  1039 SIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYF 1103
            :|||||||||||.|||||||::|:|||||||.:|:|..||..||::||||||::.:|:|.||.||
Human   822 AIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYF 886

  Fly  1104 FYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLY 1168
            ||||:.|:...||:||...||..::||:.:|||||:.:||||||..::.|:....:.|.|.|.||
Human   887 FYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLY 951

  Fly  1169 KKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVV 1233
            :....|..|.|..|:.|.|..::.:::.|:.|: |.:.|..:.:.||......||||:...:|..
Human   952 RDVAKNALLRWRVFIYWTLLGLFDALVFFFGAY-FVFENTTVTSNGQIFGNWTFGTLVFTVMVFT 1015

  Fly  1234 VNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVI---NLDYDTDIYWAYNNLLASLPVWLWI 1295
            |.|||.|::.|.::...|.|..|:|.:||.::::..:   .|:|.. :|:.:..:|:|.|.||.|
Human  1016 VTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQR-MYYVFIQMLSSGPAWLAI 1079

  Fly  1296 IVTCVACLVPDYTIRMLQRAL 1316
            ::.....|:||...::|.|.|
Human  1080 VLLVTISLLPDVLKKVLCRQL 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	31/60 (52%)
		ATPase-Plipid	74..1317	CDD:273734	444/1307 (34%)
		E1-E2_ATPase	127..>345	CDD:278548	95/235 (40%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	94/252 (37%)
ATP11A	XP_005268356.1	PhoLip_ATPase_N	42..95	CDD:292826	29/54 (54%)
		ATPase-Plipid	45..1110	CDD:273734	445/1312 (34%)
		E1-E2_ATPase	102..>187	CDD:278548	40/84 (48%)
		Cation_ATPase	477..585	CDD:289987	49/333 (15%)
		R3H	639..695	CDD:294210	34/55 (62%)
		HAD_like	<806..849	CDD:304363	28/42 (67%)
		PhoLip_ATPase_C	851..1103	CDD:292829	94/252 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144896
Domainoid	1	1.000	214	1.000	Domainoid score	I2728
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	807	1.000	Inparanoid score	I493
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.870