Protein Alignment CG4301 and ATP11A

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_001392590.1
• Gene: ATP11A / 23250
• HGNCID: 13552
• Length: 1192
• Species: Homo sapiens
• Alignment Length: 1321
• Identity: 447/1321 - (33%)
• Similarity: 665/1321 - (50%)
• Gaps: 320/1321 - (24%)

  Fly    60 GGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLL 124
            |....|.::.|  .|||.|:|||...|:|:||.|||||:||||||::.::.|:||:|.||:||.|
Human    36 GAEAYIPQRYP--DNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLIIDTPTSPVTSGL 98

  Fly   125 PLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCD 189
            ||.|||.|||.||||||.||::.||.:|..||..|:.||....:|:.:..|::::|:.|...|||
Human    99 PLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCD 163

  Fly   190 LVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDL----PTVDLPEMHKLGIIECESPTTDLYSF 250
            |:.|.|....|.|.:|||:|||||:.||....:|.    ...|:..:|  ..||||.|..|||.|
Human   164 LIFLSSNRGDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEEDIGGLH--ATIECEQPQPDLYKF 226

  Fly   251 NGKIELKG--GEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSET 313
            .|:|.:..  .:..|.||.:||:||||:.:||||.:.|.|:||||.:|:.||.:....|.::.|.
Human   227 VGRINVYSDLNDPVVRPLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEK 291

  Fly   314 YINRFLIVILVALIA---IVTLLYFLKR---------YNELFVIPKLTYLGDATDSYSVKQ-FLQ 365
            .:|.||||.|..||:   |.|:|.::.:         ||:            .|:|...:. ||:
Human   292 SMNAFLIVYLCILISKALINTVLKYMWQSEPFRDEPWYNQ------------KTESERQRNLFLK 344

  Fly   366 ---DYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQIN 427
               |:|:|::||||:||:|:|||:|:|:.:||:|:.||.::::.||.:..:||||:|||||||:.
Human   345 AFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVE 409

  Fly   428 ILFSDKTGTLTKNEMNFQQCSINGNKF----LFKKTRLEDEETKALLDINKFSANQR----VFFQ 484
            .:|:|||||||:|.|.|::|.|.|:.:    :.....|.:.....::|.:. |.|.|    :||:
Human   410 YIFTDKTGTLTENNMEFKECCIEGHVYVPHVICNGQVLPESSGIDMIDSSP-SVNGREREELFFR 473

  Fly   485 ALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDN 549
            ||.:||||||..                                                   |:
Human   474 ALCLCHTVQVKD---------------------------------------------------DD 487

  Fly   550 SVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTD 614
            ||                       ||        |   ::||:..:|
Human   488 SV-----------------------DG--------P---RKSPDGGKS----------------- 501

  Fly   615 PNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTAST 679
                                                                             
Human   502 ----------------------------------------------------------------- 501

  Fly   680 PPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEAC 744
                                                            ..|.:|||||.||||..
Human   502 ------------------------------------------------CVYISSSPDEVALVEGV 518

  Fly   745 ANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKW 809
            ..||..|....|..:.:.....|:           |.|:.|.:|.|.|.|:||||||:...|:.:
Human   519 QRLGFTYLRLKDNYMEILNRENHI-----------ERFELLEILSFDSVRRRMSVIVKSATGEIY 572

  Fly   810 IYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSS 874
            ::.|||:|.:||.......:.:.   |.:...|..|||||.:|.:.:.:|||:.....|..|..:
Human   573 LFCKGADSSIFPRVIEGKVDQIR---ARVERNAVEGLRTLCVAYKRLIQEEYEGICKLLQAAKVA 634

  Fly   875 LENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIAL 939
            |::|::...|.|.:||.:|.|||||||||.||:..|||:.:||.||||:|||||||:|||.....
Human   635 LQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETAAATCY 699

  Fly   940 SCGHIPPDAKKYF-----IME--CKNREE-------------MLLHLNALDREIIFGIG---QEC 981
            :|        |.|     ::|  .|..||             :|.|..:|.|:.:.|:.   |:.
Human   700 AC--------KLFRRNTQLLELTTKRIEEQSLHDVLFELSKTVLRHSGSLTRDNLSGLSADMQDY 756

  Fly   982 ALLIDGKSLGVALAE----ASSEFRDVAVK----CTAVLCCRLSPLQKSEVVSLIKSSNENYNTA 1038
            .|:|||.:|.:.:..    :|..:|::.::    |:||||||::||||:::|.|||.|.|:..|.
Human   757 GLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAPLQKAQIVKLIKFSKEHPITL 821

  Fly  1039 SIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYF 1103
            :|||||||||||.|||||||::|:|||||||.:|:|..||..||::||||||::.:|:|.||.||
Human   822 AIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYF 886

  Fly  1104 FYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLY 1168
            ||||:.|:...||:||...||..::||:.:|||||:.:||||||..::.|:....:.|.|.|.||
Human   887 FYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILLYSLMEQHVGIDVLKRDPTLY 951

  Fly  1169 KKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVV 1233
            :....|..|.|..|:.|.|..::.:::.|:.|: |.:.|..:.:.||......||||:...:|..
Human   952 RDVAKNALLRWRVFIYWTLLGLFDALVFFFGAY-FVFENTTVTSNGQIFGNWTFGTLVFTVMVFT 1015

  Fly  1234 VNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVI---NLDYDTDIYWAYNNLLASLPVWLWI 1295
            |.|||.|::.|.::...|.|..|:|.:||.::::..:   .|:|.. :|:.:..:|:|.|.||.|
Human  1016 VTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVIWPFLNYQR-MYYVFIQMLSSGPAWLAI 1079

  Fly  1296 IVTCVACLVPDYTIRMLQRAL 1316
            ::.....|:||...::|.|.|
Human  1080 VLLVTISLLPDVLKKVLCRQL 1100

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	444/1307 (34%)
ATP11A	NP_001392590.1	P-type_ATPase_APLT_Dnf-like	47..983	CDD:319770	407/1187 (34%)
		RDD	<965..1061	CDD:469900	28/96 (29%)