DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP11B

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_055431.1	Gene:	ATP11B / 23200	HGNCID:	13553	Length:	1177	Species:	Homo sapiens

Alignment Length:	1328	Identity:	484/1328 - (36%)
Similarity:	703/1328 - (52%)	Gaps:	250/1328 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 LWNW----------HKGSRVSTI---NDWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQN 90
            :|.|          |: |...||   |.:.|..:..||...      .|||.|:|||:..|:|:|
Human     1 MWRWIRQQLGFDPPHQ-SDTRTIYVANRFPQNGLYTPQKFI------DNRIISSKYTVWNFVPKN 58

  Fly    91 LLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSP 155
            |.|||||:||||||::.::.|:||:|.||:||.|||.|||.|||.||||||.||:.:||.||.:|
Human    59 LFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAP 123

  Fly   156 VTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKT-LM 219
            |.|:|.|.....:|:::..|:::.:.:|...|.|||||.|....|.|.:|||:||||:|||| :.
Human   124 VYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVA 188

  Fly   220 VPRD--LPTV-DLPEMHKLGIIECESPTTDLYSFNGK-IELKGGEGRVLPLSTENVLLRGSRVKN 280
            ||..  |.|| :|..:  :.:|||:.|..|||.|.|: |..:..|..|.||..|::||||:|:||
Human   189 VPETALLQTVANLDTL--VAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKN 251

  Fly   281 TECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIA---IVTLLYFL----KR 338
            |:.:.|.||||||.:|:.||.:....|.::.|..:|.|||:.||.||:   |.|:|.:.    ::
Human   252 TKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEK 316

  Fly   339 YNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLEL 403
            ::|.:...|..:   ..:|..:.:|:.|:|:||:|:|::||||||||:|:|:.:||:|:.|||:|
Human   317 WDEPWYNQKTEH---QRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDL 378

  Fly   404 YENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKA 468
            |..|:||...||||:|||||||:..:|:|||||||:|||.|::|||||.|:
Human   379 YHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKY-------------- 429

  Fly   469 LLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESH 533
                                    |..:|.|               :..||         |.:|
Human   430 ------------------------QEINGRL---------------VPEGP---------TPDS- 445

  Fly   534 NASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSN 598
                 ||.|:.:.   |..:|.|.::....||..
Human   446 -----SEGNLSYL---SSLSHLNNLSHLTTSSSF------------------------------- 471

  Fly   599 RMNNGAASDLNINQTDPNTVTNGV-EPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAH 662
                         :|.|...|..: |....|:.:||                           .|
Human   472 -------------RTSPENETELIKEHDLFFKAVSL---------------------------CH 496

  Fly   663 SYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFT 727
            :....|  :....|...|             .:|..||:                         .
Human   497 TVQISN--VQTDCTGDGP-------------WQSNLAPS-------------------------Q 521

  Fly   728 LDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTS 792
            |:|.||||||||||||.|.:|:|:.|:.:||:.|:.:            .:.|.::.||:|||.|
Human   522 LEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTL------------GKLERYKLLHILEFDS 574

  Fly   793 DRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLIS 857
            ||:||||||:...|:|.::.|||||.:.|.|.....|   ||..|:.:||..|||||.||.|..:
Human   575 DRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIE---KTRIHVDEFALKGLRTLCIAYRKFT 636

  Fly   858 EEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIK 922
            .:||::....:.:|.::|:.|::.....:..||.:|.|||||||||.|||.|.:|:.:|:.||||
Human   637 SKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIK 701

  Fly   923 IWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDG 987
            :|||||||.|||::::|||||.........::..|:..|....|..|.|.|......:..|::||
Human   702 VWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDG 766

  Fly   988 KSLGVALAEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQE 1052
            .||.:||.|....|.:|...|:||||||::||||::|:.|||.|.|...|.::||||||||||||
Human   767 TSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQE 831

  Fly  1053 AHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLF 1117
            |||||||||:|||||||.:|:|.|:|..|.:||.||||::.:|::.||.||||||:.|:...||:
Human   832 AHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLY 896

  Fly  1118 QFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYF 1182
            ||:.|||..::|||::|||||:.:||||||..::.|:......|...|.||:..:.|:.|....|
Human   897 QFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTF 961

  Fly  1183 LMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSF 1247
            |.|.:....|:.|.|:.::.....:..||..||......||||:...:|:.|.:|:.||:   .|
Human   962 LYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALET---HF 1023

  Fly  1248 WYIFTIII---SILGFVVTTVIYNVINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDY 1307
            |.....::   ||:.:.|.::.|..|...:  ..::|:.:..||:|...|..||:..|.||..|.
Human  1024 WTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDI 1088

  Fly  1308 TIRMLQRALNIKSFSIFPGKQRKLKMRE 1335
            ..::..|.|:       |....|.::.|
Human  1089 IKKVFDRHLH-------PTSTEKAQLTE 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	30/63 (48%)
		ATPase-Plipid	74..1317	CDD:273734	470/1260 (37%)
		E1-E2_ATPase	127..>345	CDD:278548	99/229 (43%)
		Cation_ATPase	<734..823	CDD:289987	40/88 (45%)
		HAD_like	<1036..1066	CDD:304363	24/29 (83%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	89/253 (35%)
ATP11B	NP_055431.1	PhoLip_ATPase_N	35..89	CDD:292826	30/59 (51%)
		ATPase-Plipid	39..1106	CDD:273734	473/1284 (37%)
		E1-E2_ATPase	96..>180	CDD:278548	40/83 (48%)
		Cation_ATPase	494..605	CDD:289987	52/189 (28%)
		HAD_like	629..868	CDD:304363	115/238 (48%)
		PhoLip_ATPase_C	847..1100	CDD:292829	90/262 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	214	1.000	Domainoid score	I2728
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32919
Inparanoid	1	1.050	807	1.000	Inparanoid score	I493
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.940