DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp10d

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_700438.3	Gene:	Atp10d / 231287	MGIID:	2450125	Length:	1469	Species:	Mus musculus

Alignment Length:	1350	Identity:	432/1350 - (32%)
Similarity:	669/1350 - (49%)	Gaps:	177/1350 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISL--LIDSPVSPMTSLLPLVFVIAVTAAK 136
            |||::|||||:.|:|:||.|||.|.||.|||.:.:::.  |:::....:| :||||.|:.:.|.|
Mouse   127 NRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEIT-MLPLVVVLTIIAIK 190

  Fly   137 QGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKS------QDVIPGELIVVERDCDVPCDLVLLRS 195
            .|.||..:|:.|..:|:. :|.:...||   |.      ::|..|:.|.:..:..:|.|:|||.|
Mouse   191 DGLEDYRKYKIDKQINNL-ITKVYSRKE---KKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFS 251

  Fly   196 TDPHGKCFITTANLDGESNLKTLMVPRDLPTVDL---PEMHKLGIIECESPTTDLYSFNGKIELK 257
            |||.|.|.|.|:.||||||||...|.|.....|.   ||... ..||||||..||..|.|.:|..
Mouse   252 TDPDGICHIETSGLDGESNLKQRQVVRGYTEQDSEVDPEKFS-SRIECESPNNDLSRFRGFLEHA 315

  Fly   258 GGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR----- 317
            ..| || .||.||:||||..::|||.|:|..||.|..:|..||:...|.|.:..|...|.
Mouse   316 NKE-RV-GLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWC 378

  Fly   318 FLIVILVALIAIVTLLYFLKRYNEL--FVIPKLTYLGDATDSYSVKQFLQDYLSF---LILFNYL 377
            .|::|::.|...:....:|.||..:  |.||:       .|...:...|..:..|   :||...|
Mouse   379 VLLLIVMCLTGALGHGIWLSRYENMLFFNIPE-------PDGRVISPVLTGFYVFWTMIILLQVL 436

  Fly   378 IPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEM 442
            |||||||:||:.::...:|::.|::.|..:.|........|:.|:||||..||||||||||:|:|
Mouse   437 IPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTENKM 501

  Fly   443 NFQQCSINGNKFLFKKT--RL--------EDEETKALLDINKFSANQRVFFQALSICHTVQVA-- 495
            .|::||:.|..:..::.  ||        |:||....|. ...|...|...|.   |.||...
Mouse   502 VFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLG-GSLSNMARPRAQG---CRTVPSGPL 562

  Fly   496 -------SGSLEQADAGTAKRE-PVT--AIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNS 550
                   |||......|....| |.:  |..|.|.|    :|:..::....:.|:|.
Mouse   563 GKPSAQLSGSTSAVGNGEGSGEVPHSRQAAFSSPME----TDVVPDTRLLDKFSQLT-------- 615

  Fly   551 VSAHP---NGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQ 612
                |   .|::.|..||.:..|.:.|  :.:.......|:..:||..|..         :.::.
Mouse   616 ----PQLLTGLDGTAQSSPLETLYIMD--FFIALAICNTVVVSAPNQPRQK---------IGLSS 665

  Fly   613 TDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTA 677
            .....:.:..|....|:.:|:  |||:|          || .|.|  :..|.|.|.|:::.....
Mouse   666 LGGMPIKSLEEIKNIFQKLSV--RRSSS----------PS-LASG--KDSSSGTPCAFVSRISFF 715

  Fly   678 STPPAGVLFRSPST-------TSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSP 735
            |.|.........|:       .|..:....|..:...:.:...|....:........|.|:|.||
Mouse   716 SRPKLSPPMEDESSQMDEIPQASNSACCTETEAQNRAVGLSVSSAEALSGPPPSASNLCYEAESP 780

  Fly   736 DEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVI 800
            ||.|||.|.............|.:.|           .||.....|||.||:|.|.|.||||||:
Mouse   781 DEAALVYAARAYRCTLQSRTPEQVMV-----------DFAALGSLTFQLLHILPFDSVRKRMSVV 834

  Fly   801 VRDTDGKK-WIYTKGAESYVFPLCA-------NSSAELV--TKTDAHISDFARLGLRTLAIARRL 855
            ||....|: .:|||||:|.:..|.:       |...:::  .:|..|:.::|:.|||||.:|:::
Mouse   835 VRHPLSKQVVVYTKGADSVIMELLSVAASDGTNPEQQMIIRERTQRHLDEYAKRGLRTLCVAKKV 899

  Fly   856 ISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAG 920
            :|:.||.::|.....|.:|::||::|..|...::|:.|.|||||.:||.||:.|.:::.:|..||
Mouse   900 MSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEALHQAG 964

  Fly   921 IKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREI------------ 973
            ||||:|||||.|||:|||.:|..:.|| .|.||:..::::...:.::|:..|:
Mouse   965 IKIWMLTGDKQETAVNIAYACKLLEPD-DKLFILNTQSQDACGMLMSAILEELQKRAQVSPELAS 1028

  Fly   974 ----------IFGIGQECALLIDGKSLGVALAEA-SSEFRDVAVKCTAVLCCRLSPLQKSEVVSL 1027
                      ..|.|: ..|:|.||:|..||.|: ..:|.::...|.||:|||.:||||||||.|
Mouse  1029 SRKNFPQPSDAQGQGR-AGLVITGKTLEFALQESLQRQFLELTAWCQAVICCRATPLQKSEVVKL 1092

  Fly  1028 IKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYH 1092
            :: ::.:..|..||||||||||||.|.:|||:.|:||.||...:|||.::|..|.:|||||||:.
Mouse  1093 VR-NHHHVLTLPIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGHWC 1156

  Fly  1093 SVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYT 1157
            ..|||.::|||||||:.::.::|.:||...||.:|:.|...|..:|:::||:|.:...:.||..:
Mouse  1157 YTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKDVS 1221

  Fly  1158 EEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCF 1222
            .|.|::.|:||:....:::.....|.:.:|.|.|.|::.|:..  :|.|.      |..:....|
Mouse  1222 AETLLQLPELYRSGQRSEEYLPLTFWITLLDAFYQSLVCFFVP--YFTYQ------GSDIDIFTF 1278

  Fly  1223 GTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNV--INLDYDTDIYWAYNNL 1285
            |..|....:.::.|.|.:||..|::.::...:.|||.:....:.:..  :..:..::.|......
Mouse  1279 GNPLNTAALFIILLHLVIESKSLTWIHMLVTVGSILSYFFFALAFGALCVTCNPPSNPYGIMRKH 1343

  Fly  1286 LASLPVWLWIIVTCVACLVPDYTIRMLQRA------LNIKSFSIFPGKQR 1329
            :.....:|..::|....|:|.:..|:||.:      |..|.|...|.::|
Mouse  1344 MLDPVFYLVCVLTTFVALLPRFLYRVLQGSVFPSPVLRAKYFDRLPPEER 1393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	22/48 (46%)
		ATPase-Plipid	74..1317	CDD:273734	427/1336 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	87/233 (37%)
		Cation_ATPase	<734..823	CDD:289987	35/89 (39%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	69/256 (27%)
Atp10d	NP_700438.3	ATPase-Plipid	124..1377	CDD:273734	427/1332 (32%)
		PhoLip_ATPase_N	<124..175	CDD:292826	22/47 (47%)
		E1-E2_ATPase	181..406	CDD:278548	86/231 (37%)
		Cation_ATPase	<779..859	CDD:289987	36/90 (40%)
		HAD_like	<1101..1132	CDD:304363	21/30 (70%)
		PhoLip_ATPase_C	1132..1377	CDD:292829	69/252 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835006
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840