Protein Alignment CG4301 and Atp10d

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_700438.3
• Gene: Atp10d / 231287
• MGIID: 2450125
• Length: 1469
• Species: Mus musculus
• Alignment Length: 1350
• Identity: 432/1350 - (32%)
• Similarity: 669/1350 - (49%)
• Gaps: 177/1350 - (13%)

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISL--LIDSPVSPMTSLLPLVFVIAVTAAK 136
            |||::|||||:.|:|:||.|||.|.||.|||.:.:::.  |:::....:| :||||.|:.:.|.|
Mouse   127 NRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEIT-MLPLVVVLTIIAIK 190

  Fly   137 QGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKS------QDVIPGELIVVERDCDVPCDLVLLRS 195
            .|.||..:|:.|..:|:. :|.:...||   |.      ::|..|:.|.:..:..:|.|:|||.|
Mouse   191 DGLEDYRKYKIDKQINNL-ITKVYSRKE---KKYIDCCWKNVTVGDFIRLSCNEIIPADMVLLFS 251

  Fly   196 TDPHGKCFITTANLDGESNLKTLMVPRDLPTVDL---PEMHKLGIIECESPTTDLYSFNGKIELK 257
            |||.|.|.|.|:.||||||||...|.|.....|.   ||... ..||||||..||..|.|.:|..
Mouse   252 TDPDGICHIETSGLDGESNLKQRQVVRGYTEQDSEVDPEKFS-SRIECESPNNDLSRFRGFLEHA 315

  Fly   258 GGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR----- 317
            ..| || .||.||:||||..::|||.|:|..||.|..:|..||:...|.|.:..|...|.
Mouse   316 NKE-RV-GLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLWC 378

  Fly   318 FLIVILVALIAIVTLLYFLKRYNEL--FVIPKLTYLGDATDSYSVKQFLQDYLSF---LILFNYL 377
            .|::|::.|...:....:|.||..:  |.||:       .|...:...|..:..|   :||...|
Mouse   379 VLLLIVMCLTGALGHGIWLSRYENMLFFNIPE-------PDGRVISPVLTGFYVFWTMIILLQVL 436

  Fly   378 IPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEM 442
            |||||||:||:.::...:|::.|::.|..:.|........|:.|:||||..||||||||||:|:|
Mouse   437 IPISLYVSIEIVKLGQIYFIQSDVDFYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTENKM 501

  Fly   443 NFQQCSINGNKFLFKKT--RL--------EDEETKALLDINKFSANQRVFFQALSICHTVQVA-- 495
            .|::||:.|..:..::.  ||        |:||....|. ...|...|...|.   |.||...
Mouse   502 VFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLG-GSLSNMARPRAQG---CRTVPSGPL 562

  Fly   496 -------SGSLEQADAGTAKRE-PVT--AIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNS 550
                   |||......|....| |.:  |..|.|.|    :|:..::....:.|:|.
Mouse   563 GKPSAQLSGSTSAVGNGEGSGEVPHSRQAAFSSPME----TDVVPDTRLLDKFSQLT-------- 615

  Fly   551 VSAHP---NGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQ 612
                |   .|::.|..||.:..|.:.|  :.:.......|:..:||..|..         :.::.
Mouse   616 ----PQLLTGLDGTAQSSPLETLYIMD--FFIALAICNTVVVSAPNQPRQK---------IGLSS 665

  Fly   613 TDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTA 677
            .....:.:..|....|:.:|:  |||:|          || .|.|  :..|.|.|.|:::.....
Mouse   666 LGGMPIKSLEEIKNIFQKLSV--RRSSS----------PS-LASG--KDSSSGTPCAFVSRISFF 715

  Fly   678 STPPAGVLFRSPST-------TSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSP 735
            |.|.........|:       .|..:....|..:...:.:...|....:........|.|:|.||
Mouse   716 SRPKLSPPMEDESSQMDEIPQASNSACCTETEAQNRAVGLSVSSAEALSGPPPSASNLCYEAESP 780

  Fly   736 DEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVI 800
            ||.|||.|.............|.:.|           .||.....|||.||:|.|.|.||||||:
Mouse   781 DEAALVYAARAYRCTLQSRTPEQVMV-----------DFAALGSLTFQLLHILPFDSVRKRMSVV 834

  Fly   801 VRDTDGKK-WIYTKGAESYVFPLCA-------NSSAELV--TKTDAHISDFARLGLRTLAIARRL 855
            ||....|: .:|||||:|.:..|.:       |...:::  .:|..|:.::|:.|||||.:|:::
Mouse   835 VRHPLSKQVVVYTKGADSVIMELLSVAASDGTNPEQQMIIRERTQRHLDEYAKRGLRTLCVAKKV 899

  Fly   856 ISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAG 920
            :|:.||.::|.....|.:|::||::|..|...::|:.|.|||||.:||.||:.|.:::.:|..||
Mouse   900 MSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEALHQAG 964

  Fly   921 IKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREI------------ 973
            ||||:|||||.|||:|||.:|..:.|| .|.||:..::::...:.::|:..|:
Mouse   965 IKIWMLTGDKQETAVNIAYACKLLEPD-DKLFILNTQSQDACGMLMSAILEELQKRAQVSPELAS 1028

  Fly   974 ----------IFGIGQECALLIDGKSLGVALAEA-SSEFRDVAVKCTAVLCCRLSPLQKSEVVSL 1027
                      ..|.|: ..|:|.||:|..||.|: ..:|.::...|.||:|||.:||||||||.|
Mouse  1029 SRKNFPQPSDAQGQGR-AGLVITGKTLEFALQESLQRQFLELTAWCQAVICCRATPLQKSEVVKL 1092

  Fly  1028 IKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYH 1092
            :: ::.:..|..||||||||||||.|.:|||:.|:||.||...:|||.::|..|.:|||||||:.
Mouse  1093 VR-NHHHVLTLPIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGHWC 1156

  Fly  1093 SVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYT 1157
            ..|||.::|||||||:.::.::|.:||...||.:|:.|...|..:|:::||:|.:...:.||..:
Mouse  1157 YTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKDVS 1221

  Fly  1158 EEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCF 1222
            .|.|::.|:||:....:::.....|.:.:|.|.|.|::.|:..  :|.|.      |..:....|
Mouse  1222 AETLLQLPELYRSGQRSEEYLPLTFWITLLDAFYQSLVCFFVP--YFTYQ------GSDIDIFTF 1278

  Fly  1223 GTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNV--INLDYDTDIYWAYNNL 1285
            |..|....:.::.|.|.:||..|::.::...:.|||.:....:.:..  :..:..::.|......
Mouse  1279 GNPLNTAALFIILLHLVIESKSLTWIHMLVTVGSILSYFFFALAFGALCVTCNPPSNPYGIMRKH 1343

  Fly  1286 LASLPVWLWIIVTCVACLVPDYTIRMLQRA------LNIKSFSIFPGKQR 1329
            :.....:|..::|....|:|.:..|:||.:      |..|.|...|.::|
Mouse  1344 MLDPVFYLVCVLTTFVALLPRFLYRVLQGSVFPSPVLRAKYFDRLPPEER 1393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	427/1336 (32%)
Atp10d	NP_700438.3	P-type_ATPase_APLT_Dnf-like	126..1264	CDD:319770	405/1211 (33%)
		Haloacid Dehalogenase-like Hydrolases	<480..>602	CDD:473868	44/129 (34%)