DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP10B

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001353581.1	Gene:	ATP10B / 23120	HGNCID:	13543	Length:	1461	Species:	Homo sapiens

Alignment Length:	1402	Identity:	431/1402 - (30%)
Similarity:	674/1402 - (48%)	Gaps:	232/1402 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DWLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPV 117
            ||        :::.::.|  .||..:|||||.||||:||.|||.|.||.|||.:.|::.:....|
Human    58 DW--------EEVSRRYP--GNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEV 112

  Fly   118 -SPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKS--QDVIPGELIV 179
             ....::|||..|:.|...|.|.||..|:|.|..:|.|.:.:....::..::.  :||..|:.|.
Human   113 FHREITMLPLAIVLFVIMIKDGMEDFKRHRFDKAINCSNIRIYERKEQTYVQKCWKDVRVGDFIQ 177

  Fly   180 VERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDL---PEMHKLGIIECE 241
            ::.:..||.|::||.|:||:|.|.:.||:||||:|||...|.:.....::   ||:....|: ||
Human   178 MKCNEIVPADILLLFSSDPNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHNTIV-CE 241

  Fly   242 SPTTDLYSFNGKIE----LKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSR 302
            .|...|..|.|.:|    .:.|.|      .|::||||..::|||..:|..:|.|..:|..||:.
Human   242 KPNNHLNKFKGYMEHPDQTRTGFG------CESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNS 300

  Fly   303 LTRNKNASSETYINRFL-----IVILVALIAIVTLLYFLKRYNE--LFVIPKLTYLGDATDSY-- 358
            ..|.|.:..|..:|..:     |:||:.||..|....:...:.|  .|.:|      ||..|:
Human   301 GPRYKRSKIERRMNIDIFFCIGILILMCLIGAVGHSIWNGTFEEHPPFDVP------DANGSFLP 359

  Fly   359 SVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEEL 423
            |.......:|:.:||...||||||||:|||.::...:|:..||:||:.|||........|:.|:|
Human   360 SALGGFYMFLTMIILLQVLIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDL 424

  Fly   424 GQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKAL-LDINKFSANQRVFF---- 483
            |||..:|||||||||:|:|.|::|:|.|:::..::.....|..|.| .|..:::..|.:.|
Human   425 GQIQYIFSDKTGTLTENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARW 489

  Fly   484 -------------QALSICHTVQV-ASGSLEQADAGTAKREPVTAIKSGPPEMYSIS---DITEE 531
                         |.|....:.:| ..|...|...|  .||     .|.||..:|.|   |:|.:
Human   490 AQDPATMRSQKGAQPLRRSQSARVPIQGHYRQRSMG--HRE-----SSQPPVAFSSSIEKDVTPD 547

  Fly   532 SHNASQQSELNVG-HTIDNSVSAHPN---------------GVNSTIISSDVNP-----LLVSDD 575
            .:..::..:..:. .|:.:|..|..:               ..||.::|:...|     :..|..
Human   548 KNLLTKVRDAALWLETLSDSRPAKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSK 612

  Fly   576 GYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTS 640
            ..|....|...:.::....:.|...::.|.||.::.:                   ||....:|:
Human   613 ALGTSLEKIQQLFQKLKLLSLSQSFSSTAPSDTDLGE-------------------SLGANVATT 658

  Fly   641 EKDLQQSWEAPSG----QAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTS-RESYAAP 700
            :.|.:......||    ...|:|                 :|....|.:..|.|.|| .|:..||
Human   659 DSDERDDASVCSGGDSTDDGGYR-----------------SSMWDQGDILESGSGTSLEEALEAP 706

  Fly   701 TFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVP 765
            .     |.|.|.|              ..|:|.||||.|||.|.............|.:.||:
Human   707 A-----TDLARPE--------------FCYEAESPDEAALVHAAHAYSFTLVSRTPEQVTVRL-- 750

  Fly   766 PHMDYKRPFAKPREE--TFQRLHVLEFTSDRKRMSVIVR-DTDGKKWIYTKGAESYVF-----PL 822
                       |:..  ||..|..|.|.|.||||||:|| ...|:..:|||||:|.:.     |.
Human   751 -----------PQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLEDPA 804

  Fly   823 CA------NSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQL 881
            |.      ....::..:|..|:..:||.|||||.||::::|||:::.:.....:|.:||:||.:|
Human   805 CVPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDEL 869

  Fly   882 SEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPP 946
            ..|....:|:.|.|||||.:||.||:.|.||:.:|:.|||::|||||||.|||:|||.|| .:..
Human   870 LMETAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSC-RLLN 933

  Fly   947 DAKKYFIMECKNRE--EMLLH-----------LNALDREIIFG--------------IGQECALL 984
            .....:.:..:|:|  |.:|:           |...||: :||              :..|..|:
Human   934 QTDTVYTINTENQETCESILNCALEELKQFRELQKPDRK-LFGFRLPSKTPSITSEAVVPEAGLV 997

  Fly   985 IDGKSL-GVALAEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVS 1048
            ||||:| .:...:...:|.::...|.:|||||.:|||||.:|.|:: ......|.||||||||||
Human   998 IDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVR-DKLRVMTLSIGDGANDVS 1061

  Fly  1049 MIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGI 1113
            |||.|.:||||.|:||.||...:|||..:|..||:|||||||:...||:.:|:|:.|||:.::.:
Human  1062 MIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNL 1126

  Fly  1114 MFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLH 1178
            :|.:||...||||::.|...:..:|:.:||||.|...:.:|..:.|.|:..|:|||...:::..:
Human  1127 LFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQNSECYN 1191

  Fly  1179 WPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESM 1243
            ...|.:.::.|.|.|:|.|:..:        |...|..:....|||.:....:..:.|.   ::|
Human  1192 LSTFWISMVDAFYQSLICFFIPY--------LAYKGSDIDVFTFGTPINTISLTTILLH---QAM 1245

  Fly  1244 YLSFWYIF---TIIISILGFVVTTVIYNV--INLDYDTDIYWAYNNLLASLPVWLWIIVTCVACL 1303
            .:..|.||   .::.|.|.:.:.:::||.  :..:..|:.||.....|::...:|...:|.|..|
Human  1246 EMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVAL 1310

  Fly  1304 VPDYTIRMLQ----RALNIKSFSI--FPGKQRKLKMR 1334
            :|.|....||    ::|..|:..|  .|..:|.|:::
Human  1311 LPRYFFLSLQGTCGKSLISKAQKIDKLPPDKRNLEIQ 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	25/64 (39%)
		ATPase-Plipid	74..1317	CDD:273734	422/1360 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	73/233 (31%)
		Cation_ATPase	<734..823	CDD:289987	34/96 (35%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	73/257 (28%)
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	396/1235 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..541		13/51 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..687		12/83 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1346..1397		0/2 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.600