DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and tat-2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_001294447.1	Gene:	tat-2 / 177256	WormBaseID:	WBGene00019166	Length:	1349	Species:	Caenorhabditis elegans

Alignment Length:	1355	Identity:	396/1355 - (29%)
Similarity:	619/1355 - (45%)	Gaps:	338/1355 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQ 137
            |.||::||.:|||:||||.|||:|||||||||:.|:..:.. |.:|..::.:|||.|:|.:|.|.
Worm    74 NVIKTSKYNIITFIPQNLFEQFQRIANFYFLVLMILQFIPQISSISWYSTAVPLVIVLAFSAIKD 138

  Fly   138 GYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKC 202
            ||:|..|:.:|..||.....|:|:|........:|..|::|.:..:..|..||:||.:::|:|.|
Worm   139 GYDDAQRHISDRNVNGRKSYVVRNGSLCEEDWSNVKVGDVIRMMSNQFVAADLLLLSTSEPYGVC 203

  Fly   203 FITTANLDGESNLK-------TLMVPRDLPTVDLPEMHKLGIIECESPTTDLYSFNGKIELKGGE 260
            ||.|..||||:|||       |..:..||..:...:    |.|.||.|...|..||||:.....|
Worm   204 FIETMELDGETNLKNRAAIACTQEMGDDLDGITRFD----GEIICEPPNNKLDKFNGKLIWNNHE 264

  Fly   261 GRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVA 325
            ..|   :.:|:||||..:|||....|..|:.|..:||.:||..|:.|..|.:.::|..::.|::.
Worm   265 YGV---NNDNILLRGCILKNTRWCYGVVVFAGKDTKLMMNSGKTKFKRTSLDRFLNILIVGIVLF 326

  Fly   326 LIA---IVTLL-----YFLKRYNELF-----VIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYL 377
            |||   |.|:|     |...||..::     |:|.....|..  ..::..||| :.|::||.|.:
Worm   327 LIAMCLICTILCAVWEYQTGRYFTIYLPWDDVVPSPEQRGGR--QIALIAFLQ-FFSYIILLNTV 388

  Fly   378 IPISLYVTIELQRVIGSWFMEWDLEL-YEN-ETDQPCVVNTSNLNEELGQINILFSDKTGTLTKN 440
            :||||||::|:.|.|.|.::.:|.:: ||| |...|...:|:.|||||||:..:|||||||||:|
Worm   389 VPISLYVSVEIIRFIHSLWINYDTQMYYENGEKSVPAKAHTTTLNEELGQVQYVFSDKTGTLTRN 453

  Fly   441 EMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAG 505
            .|.|.:|:|||
Worm   454 IMTFNKCTING------------------------------------------------------ 464

  Fly   506 TAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPL 570
                             .|..||.:..           |..|:
Worm   465 -----------------ISYGDIYDHK-----------GEVIE---------------------- 479

  Fly   571 LVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQF 635
                                                                   ||.:..||.|
Worm   480 -------------------------------------------------------TNDKTKSLDF 489

  Fly   636 RRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRS-PSTTSRESYAA 699
                       ||.                          :||.|......:: ...|.|:....
Worm   490 -----------SWN--------------------------SASEPTFKFFDKNLVDATKRQVPEI 517

  Fly   700 PTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIV 764
            ..|.|...:......:|.|.:       |.|||.||||.||..|..|.|.|:.....:::.:.::
Worm   518 DQFWRLLALCHTVMPERDKGQ-------LVYQAQSPDEHALTSAARNFGYVFRARTPQSITIEVM 575

  Fly   765 PPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAE 829
                        ..|||.:.|.:|:|.:|||||||||:..|||..:|.|||:..:......|:::
Worm   576 ------------GNEETHELLAILDFNNDRKRMSVIVKGPDGKIRLYCKGADMMIMQRIHPSTSQ 628

  Fly   830 LV-TKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNL 893
            :: |.|:.|::|||.:|||||.:..:.:....:.|:...:.:|::::::|:...:..|.:||.:|
Worm   629 IMRTSTNTHLADFANIGLRTLCLGYKDLDPAYFSDWDSRVKKASAAMQDRESAVDALYEEIEKDL 693

  Fly   894 DLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIM---- 954
            .|:||||:||.|||.|.:.:..|..|.||||||||||.|||:|||.||..:..:.|:..::
Worm   694 ILIGATAIEDKLQDGVPEAIARLSEANIKIWVLTGDKTETAINIAYSCRLLTDETKEIVVVDGQT 758

  Fly   955 ---------ECKNREEMLLHL-------------------------NALDREIIF---------- 975
                     :.:|..|.:|.|                         .::||.|:.
Worm   759 DTEVEVQLKDTRNTFEQILALPSPLGGKPRIEIETIHEESEAISSARSMDRNIVTPDLKSAEMAE 823

  Fly   976 ----GIGQECALLIDGKSLGVALA-EASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENY 1035
                |:    ||:|:|.||..||. .....|.:||..|.||:|||::||||::||.|:| .|:..
Worm   824 HESGGV----ALVINGDSLAFALGPRLERTFLEVACMCNAVICCRVTPLQKAQVVDLVK-RNKKA 883

  Fly  1036 NTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLV 1100
            .|.||||||||||||:.||:|:||.|:||.||...:|::..:|..|:|||||||.:..:|::..:
Worm   884 VTLSIGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSIGQFKYLERLLLVHGRWSYIRMAKFL 948

  Fly  1101 LYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTP 1165
            .||||||..|....|.:.|...:|:.:|:|::.:..||:.:|:||:|.:...::...:...:|.|
Worm   949 RYFFYKNFAFTLTNFWYSFFCGYSAQTVFDAVLIACYNLFFTALPVLAMGSLDQDVDDHYSLRYP 1013

  Fly  1166 QLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQ------TVAFSCFGT 1224
            :||.....|...:...|:..||..::.|::||:..:..||  |.....|:      .:||:.|..
Worm  1014 KLYLPGQFNLFFNMRIFIYSVLHGMFSSLVIFFIPYGAFY--NAAAASGKDLDDYSALAFTTFTA 1076

  Fly  1225 LLMWTVVVVVNLKLWLESMY---LSFWYIFTIIISILGFVVTTVIYNVINLDY-----DTDIYWA 1281
            |     ||||..::..::.|   :|.:.|:..:  :|.|:|..::|..:.:.:     .:..|..
Worm  1077 L-----VVVVTGQIAFDTSYWTAISHFVIWGSL--VLYFLVCFLLYEWLPVSWIVKTSSSISYGV 1134

  Fly  1282 YNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMREK 1336
            ....:.:...|..|::..|..|:|    .||.|...:.:   .|....:|::|:|
Worm  1135 AFRTMVTPHFWFSILMVSVVLLLP----VMLNRFFWLDT---HPSFADRLRIRKK 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	27/47 (57%)
		ATPase-Plipid	74..1317	CDD:273734	392/1334 (29%)
		E1-E2_ATPase	127..>345	CDD:278548	80/237 (34%)
		Cation_ATPase	<734..823	CDD:289987	32/88 (36%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	68/262 (26%)
tat-2	NP_001294447.1	PhoLip_ATPase_N	60..122	CDD:292826	27/47 (57%)
		ATPase-Plipid	71..1178	CDD:273734	393/1349 (29%)
		Cation_ATPase	526..615	CDD:289987	37/107 (35%)
		R3H	675..738	CDD:294210	32/62 (52%)
		HAD_like	<885..916	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	916..1172	CDD:292829	68/271 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920