Protein Alignment CG4301 and tat-1

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_001255165.1
• Gene: tat-1 / 176666
• WormBaseID: WBGene00013034
• Length: 1192
• Species: Caenorhabditis elegans
• Alignment Length: 1300
• Identity: 379/1300 - (29%)
• Similarity: 573/1300 - (44%)
• Gaps: 355/1300 - (27%)

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQ 137
            |||.:.||...:|||:.|.|||||..|.:||.:.::..:.| ||....|:.:|.:.:::|:|.|:
 Worm    31 NRISTCKYNGFSFLPRFLYEQFRRYNNIFFLAIALLQQIPDVSPTGRYTTAVPFLIILSVSALKE 95

  Fly   138 GYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKC 202
            .:||:.|.|:||.||:..|.::.||.....:.:||..|:.|.::.|...|.||:||.|::..|..
 Worm    96 IFEDVKRRRSDNKVNAFSVEILVDGHWIEKQWKDVSVGDFIRIDNDSLFPADLLLLASSEQQGMA 160

  Fly   203 FITTANLDGESNLKTLMVPRDLPTVDLPEMHKLGIIE----CESPTTDLYSFNGKIELKGGEGRV 263
            :|.|:|||||:|||.........|:..||  ||...|    ||.|:..:..|||.||:.|....
 Worm   161 YIETSNLDGETNLKIKQALDITSTMTSPE--KLSQFESEITCEPPSRHVNEFNGNIEINGVARH- 222

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR---FLIVILVA 325
              ...:.:||||:|:|||..:.|..:|||..|||.:||:....|:.:.:...|.   ||..:|||
 Worm   223 --FGIDQLLLRGARLKNTAWIFGAVIYTGHDSKLLMNSKRAPLKSGTIDVQTNYRIIFLFFVLVA 285

  Fly   326 LIAIVTLLYFLKRYNELFVIPKLTYLG----DATDSYSVKQFLQDYLSFLILFNYLIPISLYVTI 386
            |..|......:.|.|.   ||:..||.    |...|     ||...|:|.||:|.||||||.||:
 Worm   286 LALISATGSEIWRGNN---IPQAWYLSFLEHDPKGS-----FLWGVLTFFILYNNLIPISLQVTL 342

  Fly   387 ELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSING 451
            |:.|...:.::..|:|:|:..:|...:..||||||||||:..:.||||||||:|.|.|::.||..
 Worm   343 EVVRFFQAIYINNDIEMYDVNSDSCAIARTSNLNEELGQVKFIMSDKTGTLTRNVMKFKRLSIGS 407

  Fly   452 NKF------------LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADA 504
            ..:            |.:..|..||.:.::|::.|.          :::||||
 Worm   408 RNYGNNEDDEFADASLIEDYRQGDEHSTSILEVLKM----------MAVCHTV------------ 450

  Fly   505 GTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNP 569
                          .||
 Worm   451 --------------VPE------------------------------------------------ 453

  Fly   570 LLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQ 634
                                                                             
 Worm   454 ----------------------------------------------------------------- 453

  Fly   635 FRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAA 699
                  .||         ||
 Worm   454 ------NKD---------GQ--------------------------------------------- 458

  Fly   700 PTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIV 764
                                        |.||:|||||.|||...|:          :::.....
 Worm   459 ----------------------------LIYQSSSPDEAALVRGAAS----------QSVSFHTR 485

  Fly   765 PPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRD-TDGKKWIYTKGAESYVFPLC--ANS 826
            .|.......|.:  :||.:.|.|::|||||||||||||| ..|...:|||||::.:|...  ...
 Worm   486 QPQKVICNVFGE--DETIEILDVIDFTSDRKRMSVIVRDGAGGDIKLYTKGADTVIFERLEHGKE 548

  Fly   827 SAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIES 891
            ..|.|.....|:.|:|..|.|||..:.|.::|:||..:..|..:|..:::||.:|..:...|:|.
 Worm   549 QEEAVEYCTEHLEDYASFGYRTLCFSMRHLTEQEYSQWAPEYKKAILAIDNRAKLLADAAEKLER 613

  Fly   892 NLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMEC 956
            |:.|:||||:||.||:.|.:|:.:|.||.|::|:|||||.|||:|||.||.            .|
 Worm   614 NMILVGATAIEDKLQEWVPETIQALMAADIRVWMLTGDKRETAINIAHSCA------------LC 666

  Fly   957 KNREEMLL--------HLNALDREIIFGIGQE-----CALLIDGKSLGVAL-AEASSEFRDVAVK 1007
            ....|:|:        ....|::.:...|..|     .|::||||||..|| .||...|.|:|::
 Worm   667 HTNTELLIVDKTTYEETYQKLEQFVARAIELEKQEKGFAMVIDGKSLLHALTGEARKHFGDLALR 731

  Fly  1008 CTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCAD 1072
            |.||:|||:||:||:|||.:::...::. ..:||||||||:|||.|:||:||.|.||.|||..:|
 Worm   732 CHAVVCCRMSPMQKAEVVEMVRKLAKHV-VLAIGDGANDVAMIQAANVGVGISGEEGLQAASASD 795

  Fly  1073 FAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLY 1137
            :|..:|..|:|||||||.::..|...::||.|||||....|...|...:.:|..::::...:.::
 Worm   796 YAIPRFHFLRRLLLVHGAWNHDRSVKVILYSFYKNICLYIIELWFAMFSAWSGQTIFERWTIGMF 860

  Fly  1138 NVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFC 1202
            |||:|:.|.:.:.:.:.|...|::|:.|.|| .:..|:......|.:|:..||.||:.:|:..:.
 Worm   861 NVIFTAWPPVVLGLFDHPVPAEQIMKYPALY-ASFQNRAFSIGNFSLWIGLAIVHSLSLFFLTYA 924

  Fly  1203 FFYYNNVLLN-------------YGQTVAFSCFGTLL---MWTVVVVV----NLKLWLESMYLSF 1247
            ...:..|..|             |...||..||..||   .||..|||    ::.||     :.|
 Worm   925 TMEHQVVWDNGLTGGWLMLGNCAYTFVVATVCFKALLECDSWTWPVVVACIGSIGLW-----IVF 984

  Fly  1248 WYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRML 1312
            ..:::::...:|.:             ..|:......:::|...||.::...:|.|:.|..|:.|
 Worm   985 VIVYSLVFPHIGGI-------------GADMAGMAAIMMSSYTFWLALLFIPLATLLWDLVIKSL 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	378/1299 (29%)
tat-1	NP_001255165.1	P-type_ATPase_APLT_Dnf-like	30..922	CDD:319770	352/1166 (30%)
		MelB	<831..>1032	CDD:441813	48/219 (22%)