DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and tat-3

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_499363.3	Gene:	tat-3 / 176498	WormBaseID:	WBGene00012360	Length:	1411	Species:	Caenorhabditis elegans

Alignment Length:	1465	Identity:	440/1465 - (30%)
Similarity:	694/1465 - (47%)	Gaps:	319/1465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GAHRQTPWADQESFHLKDAFLW-----------------NWHKGSRV---STINDWL-------- 55
            |.||:|            :.||                 ....|.|:   ..:..||
Worm    27 GHHRRT------------SSLWVPPTRPIFSSPTQVIKEKAENGGRILKTHPVTRWLFPTQPMLP 79

  Fly    56 QIQIGGPQDIKKKRPKGQ--------NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLL 112
            |.::..|.:.|:..|:.:        |||.:|||:::||:|:||.||..|.||.||:.:.|::::
Worm    80 QQRLVVPNNQKEPPPRYEQPNRKYCGNRISTTKYSVLTFIPKNLFEQLHRAANLYFIFIVILNMI 144

  Fly   113 IDSPVSPMTSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAI--IKSQDVIPG 175
            |.: .....|:||:.||:.:||.|..:||..||::|..:|.|...|....::..  ::.|:::.|
Worm   145 IGA-FGKYISVLPIAFVLGITAIKDAFEDYRRYKSDQKINHSTCRVWDASQQRYRKLEWQNILVG 208

  Fly   176 ELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVDLPEMHKLGI--- 237
            :.:.:..|..:|.|::||||:|.:|.|::.|.|||||||||.....|     .:.:.|...:
Worm   209 DFVHLSHDEIIPADILLLRSSDVNGVCYVETCNLDGESNLKQRQAIR-----SMGKYHNANVPLE 268

  Fly   238 ---------IECESPTTDLYSFNGKIE-LKGGEGRVLP-------LSTENVLLRGSRVKNTECVI 285
                     |.||.||||:|.|.|::| ::||.    |       |:.|||||||..||||:.|.
Worm   269 YSPAEFNYRIACEQPTTDVYKFEGRLEAIEGGP----PLAREFTILAKENVLLRGCVVKNTDFVE 329

  Fly   286 GCAVYTGMISKLQLNSRLTRNKNASSETYIN---RFLIVILVALIAIVTLL--YFLKRYNELFVI 345
            |..:|.|..:|..||:...|.|.:|.|...|   .:.:..|:||..|..:|  .:|:.::..:::
Worm   330 GIVLYAGKDTKAMLNNNGPRYKRSSLEKMTNVDILWSVCTLLALCVIGAVLSGVWLRTFSTPYIV 394

  Fly   346 PKLTYL---------GDATDSYSVK-QFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWD 400
            |.|.::         .|:...||.. :....:.|::|:...:|||||||:||..::...|||..|
Worm   395 PFLVFIHPNSSYHNNNDSQYKYSPSYESWFSFWSYIIVLQVMIPISLYVSIEFIKIFQVWFMSQD 459

  Fly   401 LELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF----------- 454
            ..:|.::.|:.......|:.||||||..:.||||||||:|:|.|::||:|||.:
Worm   460 RNMYYDKVDKRLQCRALNITEELGQIQYVMSDKTGTLTENQMVFRRCSVNGNDYGGRPVVDAVDS 524

  Fly   455 ---LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIK 516
               |...|...|:.|:..|.:                        .:|.:|.|.|.:..|
Worm   525 SLELVASTLRSDQPTEKKLQM------------------------AALAEAAAKTRRLRP----- 560

  Fly   517 SGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSA----------------------HPNG-- 557
            |..|.:        ||..||  |.|.:|..||:.|.|                      .|:|
Worm   561 SRDPAL--------ESQLAS--SVLKLGADIDDPVFAFFLTMAICNTVVVNAKPHEDLMDPDGDI 615

  Fly   558 VNSTIISSDVNPLLVS--DDGY----GVE-------RRKRPVVIKRSPNFARSNRMNNGAASDLN 609
            |||.....:|:|...|  :||:    .||       :...||:|..          .|....::.
Worm   616 VNSRFAPEEVSPRRGSSLEDGFKYLADVEEESPASTQASTPVMITE----------ENDGFEEIE 670

  Fly   610 INQTDPNTVTNGVEPTTNFRPISLQF---RRSTSEKDLQQSWEAPSGQAPG--HRRAHSYGAPNA 669
            :.:. |...|:..:.|.....||.:.   :..:.|||...:.|...|:..|  ||
Worm   671 LIEF-PEVKTDETQMTEKEETISAEVAAKKSGSDEKDNNYNGERKEGKGFGILHR---------- 724

  Fly   670 YLTNPVTASTPPAGVL-FRSP--------STTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFI 725
                |...|.|.|.:. .:||        |::|.|:..||                   .:..|
Worm   725 ----PSILSVPFAKLKGMKSPFRRSVDKRSSSSTETAVAP-------------------PLHSF- 765

  Fly   726 FTLDYQASSPDEKALVEACANLG--MVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVL 788
                |.:.||||.|||||....|  ::....||..:.:|.....:.||            .||.|
Worm   766 ----YDSESPDELALVEAAREYGIRLLRRRFDDVIVYLRHSTSSVKYK------------VLHTL 814

  Fly   789 EFTSDRKRMSVIVRDTDGKKWI--YTKGAESYVFPLCA---NSSA---ELVTKTDAHISDFARLG 845
            .|.:||||||||:|::.|.|.|  .||||::.|.|:.:   ::||   |::.|:..|::.:|:.|
Worm   815 PFDADRKRMSVIIRESSGLKRIIVLTKGADATVIPVLSEAFSTSARGEEVIFKSQEHLTQYAKEG 879

  Fly   846 LRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVA 910
            ||||.::.::.:|||||.:..:..:|...:.:::.:..|...:.|.:|:|||.||:||.|||.|.
Worm   880 LRTLCLSMKIWTEEEYQGWKEKHEEAELDMMDKETMLAESTLRAEQDLELLGVTAIEDRLQDGVP 944

  Fly   911 DTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKN---------REEMLLHL 966
            :.:.||:.|||::|||||||:|||:|||.|.....|.      |:..|         .:.:..||
Worm   945 ECIHSLREAGIRVWVLTGDKIETAVNIAYSSRLFSPS------MDLLNIGANGVRAVSDLLTEHL 1003

  Fly   967 NALDR--EIIFGIGQECALLIDGKSLGVALAEASSE-FRDVAVKCTAVLCCRLSPLQKSEVVSLI 1028
            ..:.|  |:.........|:::..::...|...:.| |..:...|.:|||||.:||||:::|:|.
Worm  1004 KRIARAYEVSADAADSFGLVLNASTMSYCLDPHNLERFVKLLRGCRSVLCCRATPLQKAQLVNLA 1068

  Fly  1029 KSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHS 1093
            |:..:. ...:||||||||||||.|.||||:.|:||.||...:|||.|:|..|..|||||||::.
Worm  1069 KNHLKG-KVLAIGDGANDVSMIQGADVGIGLSGQEGMQAVMSSDFAMARFRFLSNLLLVHGHWNY 1132

  Fly  1094 VRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTE 1158
            .||:..:|||||||.:.:.::|.:|....||:....|.::|.:||:|:||:|.|.....::..:.
Worm  1133 YRLAQTILYFFYKNAMLVFVIFWYQIFNGFSAQVPIDPVYLMVYNLIFTSVPPLLFGCLDQDASA 1197

  Fly  1159 EKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCFG 1223
            |.|:..|:||::....|:..|..|.:.:|.|::.|:::|:  .|:|.|.      |..|....||
Worm  1198 ELLLDCPRLYEQGRLGKRYRWYSFWINMLDAVWQSLVVFF--ICYFTYR------GSNVDMWTFG 1254

  Fly  1224 TLLMWTVVVVVNLKLWLESMYLS---FWYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAYNNL 1285
            .||:..:::|....|.|...|.:   ||.:|   :|:|.|.:..::||..     ....|.:.|:
Worm  1255 HLLVTQLIIVNTFHLALFVQYWTWPMFWSMF---LSVLLFFICALLYNGF-----VTANWTWTNV 1311

  Fly  1286 -----------LASLPVWLWIIVTCVACLVPDYTI 1309
                       .:||..|:.:|::.|.||.|.|.:
Worm  1312 KDPPSMVSLKSFSSLEFWMALIISVVLCLTPRYVL 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	23/71 (32%)
		ATPase-Plipid	74..1317	CDD:273734	426/1374 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	81/244 (33%)
		Cation_ATPase	<734..823	CDD:289987	37/92 (40%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	79/256 (31%)
tat-3	NP_499363.3	PhoLip_ATPase_N	94..152	CDD:292826	21/58 (36%)
		ATPase-Plipid	103..1357	CDD:273734	426/1377 (31%)
		Cation_ATPase	<770..848	CDD:289987	35/89 (39%)
		HAD_like	<1075..1107	CDD:304363	21/31 (68%)
		PhoLip_ATPase_C	1107..1356	CDD:292829	79/256 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3083
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4775
orthoMCL	1	0.900	-	-		OOG6_102565
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.670