DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP8B3

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_006722717.1	Gene:	ATP8B3 / 148229	HGNCID:	13535	Length:	1310	Species:	Homo sapiens

Alignment Length:	1430	Identity:	366/1430 - (25%)
Similarity:	615/1430 - (43%)	Gaps:	393/1430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LGAHRQTPWADQESFHLKDAFLWNWHKGSRV-------STINDWLQIQIGGPQDIKKKRPKGQNR 75
            ||........|:.|     ||.|.....:|.       ..|..|           ::|:.| .|.
Human    90 LGQREDLQDEDRNS-----AFTWKVQANNRAYNGQFKEKVILCW-----------QRKKYK-TNV 137

  Fly    76 IKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSL-LPLVFVIAVTAAKQGY 139
            |::.||...:|||.||.|||.|::|.:||::.|:..:.|....|..|| .|:|.::.:.|.:...
Human   138 IRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLV 202

  Fly   140 EDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFI 204
            :|:.|:::|..:|:.|..::........|.||:..|:::.:.:|..||.|::||.||:|...|::
Human   203 DDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYV 267

  Fly   205 TTANLDGESNLK---TLMVP-RDLPTVDLPEMHKLGIIECESPTTDLYSFNGKIELKGGEGRVLP 265
            .|.::|||:|||   .|||. ::|.|:......: |.:.||:|.:.::.|.|.:|   ...:...
Human   268 ETVDIDGETNLKFRQALMVTHKELATIKKMASFQ-GTVTCEAPNSRMHHFVGCLE---WNDKKYS 328

  Fly   266 LSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIV 330
            |...|:||||.|::||:...|..:|.|..:|:..|......|....:..:|:.::||.::::.:.
Human   329 LDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVC 393

  Fly   331 TLLYF-----LKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQR 390
            .:|.|     :|.:.:...     ||.....|....:....:.|||||.:..||:|:::..|...
Human   394 LVLAFGFGFSVKEFKDHHY-----YLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIY 453

  Fly   391 VIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKFL 455
            :..|.|::||:::|....|.|....:::||:.|||:..:|||||||||:|.:.|.:|.|:|
Human   454 LGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKCCISG---- 514

  Fly   456 FKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGPP 520
                                    ||:                                   ||
Human   515 ------------------------RVY-----------------------------------GP- 519

  Fly   521 EMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRP 585
                                       |:..:..|.          .||.|.:
Human   520 ---------------------------DSEATTRPK----------ENPYLWN------------ 535

  Fly   586 VVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEA 650
                   .||....:.:.||                          .|...|:..::.:::.|..
Human   536 -------KFADGKLLFHNAA--------------------------LLHLVRTNGDEAVREFWRL 567

  Fly   651 PSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQ 715
               .|..|                                                |::||...:
Human   568 ---LAICH------------------------------------------------TVMVRESPR 581

  Fly   716 RRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE 780
            .|.::       |.|||:||||.|||.|..|.|.|:.....:|:.:            .....|.
Human   582 ERPDQ-------LLYQAASPDEGALVTAARNFGYVFLSRTQDTVTI------------MELGEER 627

  Fly   781 TFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFARLG 845
            .:|.|.:::|.|.||||||:||..:|...:|||||::.:|.......| :...|:..::.||:..
Human   628 VYQVLAIMDFNSTRKRMSVLVRKPEGAICLYTKGADTVIFERLHRRGA-MEFATEEALAAFAQET 691

  Fly   846 LRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVA 910
            ||||.:|.|.::|:.|:|:.....:|:..|:||.|..::.|.::|.:|.||||||:||.|||.|.
Human   692 LRTLCLAYREVAEDIYEDWQQRHQEASLLLQNRAQALQQVYNEMEQDLRLLGATAIEDRLQDGVP 756

  Fly   911 DTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECKNREEMLLHL-----NALD 970
            :|:..|:.:.||||||||||.|||:||..:|..:   ::...|:|.|....:|...     |.|.
Human   757 ETIKCLKKSNIKIWVLTGDKQETAVNIGFACELL---SENMLILEEKEISRILETYWENSNNLLT 818

  Fly   971 REIIFGIGQECALLIDG-----------------------------------------------K 988
            ||.:..:  :.||:|:|                                               :
Human   819 RESLSQV--KLALVINGDFLDKLLVSLRKEPRALAQNVNMDEAWQELGQSRRDFLYARRLSLLCR 881

  Fly   989 SLGVAL---------AEASSE------FRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTA 1038
            ..|:.|         |..|||      |.|:|.||.||:|||::|.||:.:|:|:|..:: ..|.
Human   882 RFGLPLAAPPAQDSRARRSSEVLQERAFVDLASKCQAVICCRVTPKQKALIVALVKKYHQ-VVTL 945

  Fly  1039 SIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYF 1103
            :|||||||::||:.|.||:|:.|:||.||.:.:||...:||.|:|||||||.:..||:...:.||
Human   946 AIGDGANDINMIKTADVGVGLAGQEGMQAVQNSDFVLGQFCFLQRLLLVHGRWSYVRICKFLRYF 1010

  Fly  1104 FYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLY 1168
            |||::..|.:...|..:..|:...:|:..||.|:|::|::||:|:|.:.|:..:.|:.:..|:||
Human  1011 FYKSMASMMVQVWFACYNGFTGQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVSAEQSLEKPELY 1075

  Fly  1169 KKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAF----------CFFYYNNVLLNYGQTVAFSCFG 1223
            .....::..::..|:..:...:..|::.|:...          .|..:.    ::...||.||
Human  1076 VVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTLWISRDTAGPASFSDHQ----SFAVVVALSC-- 1134

  Fly  1224 TLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGF--VVTTVIYNVINLDYDTDIYWAYN--- 1283
             ||..|:.|::.:|.|      :...:.||::| |||  ::||.          |..:|.:.
Human  1135 -LLSITMEVILIIKYW------TALCVATILLS-LGFYAIMTTT----------TQSFWLFRVSP 1181

  Fly  1284 ----------NLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMREKFE 1338
                      ::::|..:.|.::::......|...:|:           |||..:......||.|
Human  1182 TTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRV-----------IFPALKELRAKEEKVE 1235

Fly 1339 1338
Human 1236 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	21/63 (33%)
		ATPase-Plipid	74..1317	CDD:273734	348/1344 (26%)
		E1-E2_ATPase	127..>345	CDD:278548	61/226 (27%)
		Cation_ATPase	<734..823	CDD:289987	32/88 (36%)
		HAD_like	<1036..1066	CDD:304363	17/29 (59%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	65/273 (24%)
ATP8B3	XP_006722717.1	PhoLip_ATPase_N	108..184	CDD:292826	24/87 (28%)
		ATPase-Plipid	133..1220	CDD:273734	349/1354 (26%)
		Cation_ATPase	<593..669	CDD:289987	32/87 (37%)
		HAD_like	<931..975	CDD:304363	21/44 (48%)
		PhoLip_ATPase_C	975..1220	CDD:292829	65/279 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750