DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp9a

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	NP_056546.2	Gene:	Atp9a / 11981	MGIID:	1330826	Length:	1047	Species:	Mus musculus

Alignment Length:	1301	Identity:	348/1301 - (26%)
Similarity:	566/1301 - (43%)	Gaps:	314/1301 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 DWLQ-----------IQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVM 106
            :||:           :.:|.|:...::.|:  |.|.:.||...||||..|..|||...|||||::
Mouse    26 EWLRCCGGGEPRPRTVWLGHPEKRDQRYPR--NVINNQKYNFFTFLPGVLFSQFRYFFNFYFLLL 88

  Fly   107 TIISLLIDSPVSPM-TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQ 170
            .....:.:..:..: |..:||.||:|||..::..|:|..|..|..:||...:.:.......:||.
Mouse    89 ACSQFVPEMRLGALYTYWVPLGFVLAVTIIREAVEEIRCYVRDKEMNSQVYSRLTSRGTVKVKSS 153

  Fly   171 DVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVP----RDLPT-VDLP 230
            ::..|:||:||::..||.|::.||:::.:|.||:.|..||||::.| |.:|    :.||| .||.
Mouse   154 NIQVGDLILVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWK-LRLPVACTQRLPTAADLL 217

  Fly   231 EMHKLGIIECESPTTDLYSFNGKIELKGGEGRVL-PLSTENVLLRGSRVKNTECVIGCAVYTGMI 294
            ::.  ..:..|.|..|:::|.|....:..:..:. .||.||.|..|: |..:..|:|..:|||..
Mouse   218 QIR--SYVYAEEPNIDIHNFLGTFTREDSDPPISESLSIENTLWAGT-VIASGTVVGVVLYTGRE 279

  Fly   295 SKLQLNSRLTRNKNASSETYINRFLIVILVALIAI----VTLLYFLKRYNELFVIPKLTYLGDAT 355
            .:..:|:...|:|....:..:|....::..||:.:    |.|.:|..|:
Mouse   280 LRSVMNTSDPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRW---------------- 328

  Fly   356 DSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLN 420
                   :|| .:.||:||:.:|||||.|.:::.:::.||.:..|.::      ...||.:|.:.
Mouse   329 -------YLQ-IIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKI------PGTVVRSSTIP 379

  Fly   421 EELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQA 485
            |:||:|:.|.:|||||||:|||            :||:..|
Mouse   380 EQLGRISYLLTDKTGTLTQNEM------------VFKRLHL------------------------ 408

  Fly   486 LSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNS 550
                .||.....|:::..:                .::||  .|::|.:...|.    |.|:...
Mouse   409 ----GTVAYGLDSMDEVQS----------------HIFSI--YTQQSQDPPAQK----GPTVTTK 447

  Fly   551 VSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDP 615
            |                             ||            ..|:|::....:....:...|
Mouse   448 V-----------------------------RR------------TMSSRVHEAVKAIALCHNVTP 471

  Fly   616 NTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTP 680
            ...:|||..            ::.:||..:.|...
Mouse   472 VYESNGVTD------------QAEAEKQFEDSCRV------------------------------ 494

  Fly   681 PAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACA 745
                                                             ||||||||.|||:...
Mouse   495 -------------------------------------------------YQASSPDEVALVQWTE 510

  Fly   746 NLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQR--LHVLEFTSDRKRMSVIVRD-TDGK 807
            ::|:...|.|..::::|             .|.::....  |.|..||.:.|||.:|||| :.|:
Mouse   511 SVGLTLVGRDQSSMQLR-------------TPGDQVLNLTILQVFPFTYESKRMGIIVRDESTGE 562

  Fly   808 KWIYTKGAESYVFPLCANSSAELVTKTD---AHISDFARLGLRTLAIARRLISEEEYQDFLVELA 869
            ...|.|||:..:        |.:|...|   ....:.||.|||.|.:|::.::||:||||.....
Mouse   563 ITFYMKGADVVM--------AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYV 619

  Fly   870 QANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETA 934
            ||..|:.:|..........:|..::||..|.|||.||.||..||.:|:.||||:|:|||||:|||
Mouse   620 QAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETA 684

  Fly   935 LNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASS 999
            ...|.:...:..:...:......||.|..|.|||..|:      .:|||:|.|.||.|.|.....
Mouse   685 TCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRK------HDCALVISGDSLEVCLKYYEY 743

  Fly  1000 EFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREG 1064
            ||.::|.:|.||:|||.:|.||:::|.|::...... |.::|||.||||||||:..|:|:.|:||
Mouse   744 EFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKL-TCAVGDGGNDVSMIQESDCGVGVEGKEG 807

  Fly  1065 RQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVY 1129
            :||:..|||:..:|..|.|||:|||.....|.:.|..:..::::....:..:|.....|:|..:|
Mouse   808 KQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLY 872

  Fly  1130 DSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSV 1194
            ....:..|:.|||..|: |..:.:|....|..|..|:|||.....:.|.:..||:|||.:||...
Mouse   873 QGFLIIGYSTIYTMFPV-FSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGS 936

  Fly  1195 IIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTI--IISI 1257
            .|.|.|...|....|     ..||.|....:|...::|.:.::.|       .| :.|:  ::|:
Mouse   937 TIMYGALLLFESEFV-----HIVAISFTSLILTELLMVALTIQTW-------HW-LMTVAELLSL 988

  Fly  1258 LGFVVTTVIYNVINLDYDTDIYWAYNNLLASLP-VWLWIIVTCVACLVPDYTIRMLQRALNIKSF 1321
            ..::.:.|.     |....|:|:     :|:|. :|...::|.|:|| |.|.::.|:|..:..|:
Mouse   989 ACYIASLVF-----LHEFIDVYF-----IATLSFLWKVSVITLVSCL-PLYVLKYLRRRFSPPSY 1042

  Fly  1322 S 1322
            |
Mouse  1043 S 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	20/64 (31%)
		ATPase-Plipid	74..1317	CDD:273734	341/1262 (27%)
		E1-E2_ATPase	127..>345	CDD:278548	66/227 (29%)
		Cation_ATPase	<734..823	CDD:289987	28/91 (31%)
		HAD_like	<1036..1066	CDD:304363	17/29 (59%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	67/251 (27%)
Atp9a	NP_056546.2	PhoLip_ATPase_N	40..104	CDD:292826	20/65 (31%)
		ATPase-Plipid	53..1045	CDD:273734	344/1274 (27%)
		E1-E2_ATPase	109..337	CDD:278548	70/255 (27%)
		Cation_ATPase	<499..573	CDD:289987	28/86 (33%)
		HAD_like	652..802	CDD:119389	67/156 (43%)
		PhoLip_ATPase_C	811..1039	CDD:292829	67/252 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834996
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930