DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and Atp8a1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_017176112.1	Gene:	Atp8a1 / 11980	MGIID:	1330848	Length:	1177	Species:	Mus musculus

Alignment Length:	1344	Identity:	429/1344 - (31%)
Similarity:	630/1344 - (46%)	Gaps:	326/1344 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GFRRIDRLGAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQIQIGGPQDIKKKRPKGQNR 75
            |:.:.|.:.  .:|..||||                .|.|      |.|..||..|    ...|.
Mouse    30 GYEKTDDVS--EKTSLADQE----------------EVRT------IFINQPQLTK----FCNNH 66

  Fly    76 IKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQGY 139
            :.:.||.:|||||:.|..||||.||.:||.:.::..:.| ||....|:|:||:|::||.|.|:..
Mouse    67 VSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEII 131

  Fly   140 EDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFI 204
            |||.|::.||.||.....|:|:|...|:..:.|..||::.|.....:|.||:.|.|::|...|:|
Mouse   132 EDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLLSLSSSEPQAMCYI 196

  Fly   205 TTANLDGESNLKTLMVPRDLP-TVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRVL 264
            .|:|||||:|||   :.:.|| |.|:.::..|    |.||||||...||.|.|.|.| .|.|.|
Mouse   197 ETSNLDGETNLK---IRQGLPATSDIKDIDSLMRISGRIECESPNRHLYDFVGNIRL-DGHGTV- 256

  Fly   265 PLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNS-----RLTRNKNASSETYINRFLIVILV 324
            ||..:.:||||::::||:.|.|..||||..:||..||     :|:..:..::...:..|.|:|.:
Mouse   257 PLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAM 321

  Fly   325 ALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQ 389
            :|:..|....:.:|::.......|.|.|       ...|..::|:|:||||.||||||.||:|:.
Mouse   322 SLVCSVGSAIWNRRHSGKDWYLHLHYGG-------ASNFGLNFLTFIILFNNLIPISLLVTLEVV 379

  Fly   390 RVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF 454
            :...::|:.|||:::...||...:..||||||||||:..:|||||||||.|.|.|::|:|.|
Mouse   380 KFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAG--- 441

  Fly   455 LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGP 519
                                                   ||.|.:.:
Mouse   442 ---------------------------------------VAYGHVPE------------------ 449

  Fly   520 PEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKR 584
            ||.|..|....:|.....:...|....:||..:.||..
Mouse   450 PEDYGCSPDEWQSSQFGDEKTFNDPSLLDNLQNNHPTA--------------------------- 487

  Fly   585 PVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWE 649
            |::.:
Mouse   488 PIICE------------------------------------------------------------ 492

  Fly   650 APSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAES 714
                                :||......|                  |.|
Mouse   493 --------------------FLTMMAVCHT------------------AVP-------------- 505

  Fly   715 QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPRE 779
            :|..::|       .|||:||||.|||.|...|..|:||...:::.:.            :..:|
Mouse   506 EREGDKI-------IYQAASPDEGALVRAAKQLNFVFTGRTPDSVIID------------SLGQE 551

  Fly   780 ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSS--AELVTKTDAHISDFA 842
            |.::.|:||||||.||||||:||...||..:|.|||::.::...|.:|  .|:..|   |:..||
Mouse   552 ERYELLNVLEFTSARKRMSVVVRTPSGKLRLYCKGADTVIYERLAETSKYKEITLK---HLEQFA 613

  Fly   843 RLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQD 907
            ..|||||..|...|||.:::::.....:|::|::||....||.|..||.||.||||||:||.|||
Mouse   614 TEGLRTLCFAVAEISESDFEEWRAVYHRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQD 678

  Fly   908 DVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECK---NREEMLLHL--- 966
            .|.:|:.:|..|.||||:|||||.|||:||..||..:..:.....|.|..   .||.:..|.
Mouse   679 QVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLKRNMGMIVINEGSLDGTRETLSRHCTTL 743

  Fly   967 -NALDREIIFGIGQECALLIDGKSLGVALAEASSE-FRDVAVKCTAVLCCRLSPLQKSEVVSLIK 1029
             :||.:|      .:.||:||||:|..||.....: |.|:|:.|.||:|||:|||||||||.::|
Mouse   744 GDALRKE------NDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVK 802

  Fly  1030 SSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSV 1094
             ......|.:||||||||||||.||||:||.|.||.|||..:|::.|:|..||.||:|||.::..
Mouse   803 -KQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYN 866

  Fly  1095 RLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEE 1159
            |:|..:||.||||||...|...|.|...||...:::...:.||||::|::|.|.:.|.|:...:|
Mouse   867 RVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKE 931

  Fly  1160 KLMRTPQLYKKNTDNKQLHWPYFLMWV--LFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFSCF 1222
            .:::.|:|||  |....|.:...:.||  |..::||||:|:|......|..|..| |:|..:...
Mouse   932 NMLKYPELYK--TSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGN-GKTSDYLLL 993

  Fly  1223 GTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAYNNLLA 1287
            |..:...||:.|.||..||:   |:|..|: .|:|.|.:...|::           :..|::|..
Mouse   994 GNFVYTFVVITVCLKAGLET---SYWTWFS-HIAIWGSIALWVVF-----------FGIYSSLWP 1043

  Fly  1288 SLPV-----------------WLWIIVTCVACLVPDYTIRMLQR 1314
            ::|:                 |:.::...||.|:.|...::::|
Mouse  1044 AVPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIKR 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	25/64 (39%)
		ATPase-Plipid	74..1317	CDD:273734	415/1281 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	84/227 (37%)
		Cation_ATPase	<734..823	CDD:289987	35/88 (40%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	80/266 (30%)
Atp8a1	XP_017176112.1	ATPase-Plipid	62..1099	CDD:273734	415/1284 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820