DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and ATP8A1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_011511917.1	Gene:	ATP8A1 / 10396	HGNCID:	13531	Length:	1171	Species:	Homo sapiens

Alignment Length:	1351	Identity:	435/1351 - (32%)
Similarity:	638/1351 - (47%)	Gaps:	333/1351 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GFRRIDRLGAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQIQIGGPQDIKKKRPKGQNR 75
            |:.:.|.:.  .:|..||||                .|.|      |.|..||..|    ...|.
Human    17 GYEKTDDVS--EKTSLADQE----------------EVRT------IFINQPQLTK----FCNNH 53

  Fly    76 IKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQGY 139
            :.:.||.:|||||:.|..||||.||.:||.:.::..:.| ||....|:|:||:|::||.|.|:..
Human    54 VSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEII 118

  Fly   140 EDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFI 204
            |||.|::.||.||.....|:|:|...|:..:.|..|::::::....:|.|.|||.|::|...|:|
Human   119 EDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYI 183

  Fly   205 TTANLDGESNLKTLMVPRDLP-TVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGRVL 264
            .|:|||||:|||   :.:.|| |.|:.::..|    |.||||||...||.|.|.|.| .|.|.|
Human   184 ETSNLDGETNLK---IRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRL-DGHGTV- 243

  Fly   265 PLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNS-----RLTRNKNASSETYINRFLIVILV 324
            ||..:.:||||::::||:.|.|..||||..:||..||     :|:..:..::...:..|.|:|.:
Human   244 PLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAM 308

  Fly   325 ALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQ 389
            :|:..|....:.:|::.......|.|.|       ...|..::|:|:||||.||||||.||:|:.
Human   309 SLVCSVGSAIWNRRHSGKDWYLNLNYGG-------ASNFGLNFLTFIILFNNLIPISLLVTLEVV 366

  Fly   390 RVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGNKF 454
            :...::|:.|||:::...||...:..||||||||||:..:|||||||||.|.|.|::|:|.|
Human   367 KFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAG--- 428

  Fly   455 LFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKSGP 519
                                                   ||.|.:.:
Human   429 ---------------------------------------VAYGHVPE------------------ 436

  Fly   520 PEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKR 584
            ||.|..|  .:|..|:.                                        :|.|:
Human   437 PEDYGCS--PDEWQNSQ----------------------------------------FGDEK--- 456

  Fly   585 PVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWE 649
                    .|:.|:.:.|     |..|           .||.   ||..:|
Human   457 --------TFSDSSLLEN-----LQNN-----------HPTA---PIICEF-------------- 480

  Fly   650 APSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAES 714
                                 ||......|                  |.|
Human   481 ---------------------LTMMAVCHT------------------AVP-------------- 492

  Fly   715 QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPRE 779
            :|..::|       .|||:||||.|||.|...|..|:||...:::.:.            :..:|
Human   493 EREGDKI-------IYQAASPDEGALVRAAKQLNFVFTGRTPDSVIID------------SLGQE 538

  Fly   780 ETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSS--AELVTKTDAHISDFA 842
            |.::.|:||||||.|||||||||...||..:|.|||::.::...|.:|  .|:..|   |:..||
Human   539 ERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRLAETSKYKEITLK---HLEQFA 600

  Fly   843 RLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQD 907
            ..|||||..|...|||.::|::.....:|::|::||....||.|..||.||.||||||:||.|||
Human   601 TEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQD 665

  Fly   908 DVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECK----------NREEM 962
            .|.:|:.:|..|.||||:|||||.|||:||..||..:..:.....|.|..          .||.:
Human   666 QVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDVEDRAVEGTRETL 730

  Fly   963 LLHL----NALDREIIFGIGQECALLIDGKSLGVALAEASSE-FRDVAVKCTAVLCCRLSPLQKS 1022
            ..|.    :||.:|      .:.||:||||:|..||.....: |.|:|:.|.||:|||:||||||
Human   731 SRHCTTLGDALRKE------NDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKS 789

  Fly  1023 EVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLV 1087
            |||.::| ......|.:||||||||||||.||||:||.|.||.|||..:|::.|:|..||.||::
Human   790 EVVEMVK-KQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMI 853

  Fly  1088 HGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAIS 1152
            ||.::..|:|..:||.||||||...|...|.|...||...:::...:.||||::|::|.|.:.|.
Human   854 HGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIF 918

  Fly  1153 EKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWV--LFAIYHSVIIFYFAFCFFYYNNVLLNYGQ 1215
            |:...:|.:::.|:|||  |....|.:...:.||  |..::||||:|:|......|.....| |:
Human   919 ERSCRKENMLKYPELYK--TSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGN-GK 980

  Fly  1216 TVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDIYW 1280
            |..:...|..:...||:.|.||..||:   |:|..|: .|:|.|.:...|::           :.
Human   981 TSDYLLLGNFVYTFVVITVCLKAGLET---SYWTWFS-HIAIWGSIALWVVF-----------FG 1030

  Fly  1281 AYNNLLASLPV-----------------WLWIIVTCVACLVPDYTIRMLQR 1314
            .|::|..::|:                 |:.::...||.|:.|...::::|
Human  1031 IYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKR 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	25/64 (39%)
		ATPase-Plipid	74..1317	CDD:273734	421/1288 (33%)
		E1-E2_ATPase	127..>345	CDD:278548	83/227 (37%)
		Cation_ATPase	<734..823	CDD:289987	36/88 (41%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	78/266 (29%)
ATP8A1	XP_011511917.1	PhoLip_ATPase_N	38..100	CDD:292826	26/71 (37%)
		ATPase-Plipid	49..1093	CDD:273734	421/1291 (33%)
		E1-E2_ATPase	106..>191	CDD:278548	32/84 (38%)
		Cation_ATPase	486..581	CDD:289987	44/145 (30%)
		HAD_like	<803..853	CDD:304363	32/49 (65%)
		PhoLip_ATPase_C	834..1086	CDD:292829	78/266 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820