DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8a2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_012813389.2	Gene:	atp8a2 / 101730757	XenbaseID:	XB-GENE-6036032	Length:	1197	Species:	Xenopus tropicalis

Alignment Length:	1295	Identity:	409/1295 - (31%)
Similarity:	615/1295 - (47%)	Gaps:	304/1295 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 IQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPM 120
            |.|..||..|.:    .|.:.:.||:::||||:.|.||.||.||.:||.:.::..:.| ||....
Frog    68 ILINQPQSCKFR----DNTVSTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRY 128

  Fly   121 TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCD 185
            |:|:||:|::.|...|:..||..|::.||.||.....|::.|....:..::|..|:::.|.....
Frog   129 TTLVPLIFILTVAGIKEIIEDYKRHKADNTVNKKKTIVLKGGTWQNMVWREVAVGDIVKVTNGQH 193

  Fly   186 VPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTV-------DLPEMHKLGIIECESP 243
            :|.|:::|.|::|...|:|.|:|||||:|||   :.:.||..       ||.:|  .|.||||.|
Frog   194 LPADMIILSSSEPQAMCYIETSNLDGETNLK---IRQGLPATSNLLSEEDLVKM--TGRIECEGP 253

  Fly   244 TTDLYSFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKN 308
            ...||.|.|.:.|  |....:|:..|.:||||::::||:.|||..||||..:||..||.....|.
Frog   254 NRHLYDFIGNLRL--GTNNPVPVGPEQILLRGAQIRNTQWVIGIVVYTGHDTKLMQNSTKAPLKR 316

  Fly   309 ASSETYIN-----RFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYL 368
            ::.|...|     .|.|::::||::.|..|.:..:|.     ....|||| .|:.|. .|..:.|
Frog   317 SNVEKVTNVQILVLFGILLVMALVSSVGALLWNWKYE-----GTNWYLGD-IDAVST-NFGYNLL 374

  Fly   369 SFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDK 433
            :|:||:|.||||||.||:|:.:...:.|:.||.::|.:|||.|.:..||||||||||:..|||||
Frog   375 TFIILYNNLIPISLLVTLEVVKFTQALFINWDRDMYYSETDTPAMARTSNLNEELGQVKYLFSDK 439

  Fly   434 TGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGS 498
            |||||.|.|:|::|||.|
Frog   440 TGTLTCNVMHFKKCSIGG----------------------------------------------- 457

  Fly   499 LEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTII 563

Frog   458 ----------------------------------------------------------------- 457

  Fly   564 SSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNF 628
                                                                  :|.|..|
Frog   458 ------------------------------------------------------ITYGHFP---- 464

  Fly   629 RPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTS 693
                 :|.|..|.:|.        .|.|....:..:..|.                ||::   ..
Frog   465 -----EFERERSSEDF--------SQLPTTSESCDFDDPK----------------LFQN---IE 497

  Fly   694 RESYAAPTFTRQPTILVRAES-QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDE 757
            .:|....|.....|:|....: ...|:|     .|:.||||||||.|||:....||..:||...:
Frog   498 NDSPTGDTIKEFLTLLAVCHTVVPEKDE-----DTIIYQASSPDEGALVKGARKLGYTFTGRTPD 557

  Fly   758 TLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPL 822
            ::.:.            |..:|::|:.|:||||:|:|||||||||...|...:|.|||::.:|..
Frog   558 SVIID------------AMGKEQSFELLNVLEFSSNRKRMSVIVRTPSGNLRLYCKGADNVIFER 610

  Fly   823 CANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYA 887
            .:..| :.:.:|..|:..||..|||||.:|...:.:.||:.:|...::|:..:::|.|..||||.
Frog   611 LSRES-KYMEQTLNHLEQFASEGLRTLCLAYCDLQDSEYEAWLNVHSEASVVIKDRAQKLEECYE 674

  Fly   888 KIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYF 952
            .||.:|.||||||:||.||..|.:|:.:|..|.||||||||||.|||:||..||..:........
Frog   675 IIEKDLMLLGATAIEDRLQGGVPETIATLMKAEIKIWVLTGDKQETAVNIGYSCRLVSQTMSLIV 739

  Fly   953 IMECK---NREEMLLHLNALDREIIFGIGQE--CALLIDGKSLGVALA-EASSEFRDVAVKCTAV 1011
            :.|..   .|..:..|...|..    |:|:|  .||:|||::|..||: |....|.|:|:.|.||
Frog   740 VNEDSLDATRSTLTNHCTNLGD----GLGKENDLALIIDGQTLKYALSFEVRQSFLDLALSCKAV 800

  Fly  1012 LCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFA 1076
            :|||:|||||||:|.::| .:.|..|.:||||||||.|||.||||:||.|.||.||...:|:|.|
Frog   801 ICCRVSPLQKSEIVDMVK-KHVNAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIA 864

  Fly  1077 KFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIY 1141
            :||.|::||||||.:...|::..:||.||||:|...|...|.....||...:::...:.|||||:
Frog   865 QFCYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAVVNGFSGQVLFERWCIGLYNVIF 929

  Fly  1142 TSLPILFIAISEKPYTEEKLMRTPQLYK--KNTD--NKQLHWPYFLMWVLFAIYHSVIIFYFAFC 1202
            |:||...:.|.|:..:::.::|.|||||  :|.|  |.::.|.:    .:.|:.||:|:|:|...
Frog   930 TALPPFTLGICERSCSQDSMLRFPQLYKITQNADGFNTRVFWGH----CINALIHSIILFWFPLK 990

  Fly  1203 FFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIY 1267
            ...::.|..| ||...:...|.::...|||.|.||..||:   :.|..|: .:::.|.::..:::
Frog   991 MLEHDAVFTN-GQVTDYLFVGNIVYTYVVVTVCLKAGLET---TAWTKFS-HLAVWGSMLMWLVF 1050

  Fly  1268 NVINLDYDTDIYWAYNNLLASLPV-----------------WLWIIVTCVACLVPDYTIR 1310
                       :.||:.:..::|:                 ||.:::...|||:.|.|.|
Frog  1051 -----------FGAYSAIWPTIPIAPDMLGQAGMVLTSGYFWLGLLLVPTACLLRDVTWR 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	24/64 (38%)
		ATPase-Plipid	74..1317	CDD:273734	404/1278 (32%)
		E1-E2_ATPase	127..>345	CDD:278548	77/229 (34%)
		Cation_ATPase	<734..823	CDD:289987	35/88 (40%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	77/264 (29%)
atp8a2	XP_012813389.2	ATPase-Plipid	78..1115	CDD:273734	404/1285 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010