Protein Alignment CG4301 and atp8a2

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: XP_012813389.2
• Gene: atp8a2 / 101730757
• XenbaseID: XB-GENE-6036032
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1295
• Identity: 409/1295 - (31%)
• Similarity: 615/1295 - (47%)
• Gaps: 304/1295 - (23%)

  Fly    57 IQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPM 120
            |.|..||..|.:    .|.:.:.||:::||||:.|.||.||.||.:||.:.::..:.| ||....
 Frog    68 ILINQPQSCKFR----DNTVSTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRY 128

  Fly   121 TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCD 185
            |:|:||:|::.|...|:..||..|::.||.||.....|::.|....:..::|..|:::.|.....
 Frog   129 TTLVPLIFILTVAGIKEIIEDYKRHKADNTVNKKKTIVLKGGTWQNMVWREVAVGDIVKVTNGQH 193

  Fly   186 VPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVPRDLPTV-------DLPEMHKLGIIECESP 243
            :|.|:::|.|::|...|:|.|:|||||:|||   :.:.||..       ||.:|  .|.||||.|
 Frog   194 LPADMIILSSSEPQAMCYIETSNLDGETNLK---IRQGLPATSNLLSEEDLVKM--TGRIECEGP 253

  Fly   244 TTDLYSFNGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKN 308
            ...||.|.|.:.|  |....:|:..|.:||||::::||:.|||..||||..:||..||.....|.
 Frog   254 NRHLYDFIGNLRL--GTNNPVPVGPEQILLRGAQIRNTQWVIGIVVYTGHDTKLMQNSTKAPLKR 316

  Fly   309 ASSETYIN-----RFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYL 368
            ::.|...|     .|.|::::||::.|..|.:..:|.     ....|||| .|:.|. .|..:.|
 Frog   317 SNVEKVTNVQILVLFGILLVMALVSSVGALLWNWKYE-----GTNWYLGD-IDAVST-NFGYNLL 374

  Fly   369 SFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDK 433
            :|:||:|.||||||.||:|:.:...:.|:.||.::|.:|||.|.:..||||||||||:..|||||
 Frog   375 TFIILYNNLIPISLLVTLEVVKFTQALFINWDRDMYYSETDTPAMARTSNLNEELGQVKYLFSDK 439

  Fly   434 TGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGS 498
            |||||.|.|:|::|||.|
 Frog   440 TGTLTCNVMHFKKCSIGG----------------------------------------------- 457

  Fly   499 LEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTII 563
                                                                             
 Frog   458 ----------------------------------------------------------------- 457

  Fly   564 SSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNF 628
                                                                  :|.|..|
 Frog   458 ------------------------------------------------------ITYGHFP---- 464

  Fly   629 RPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTS 693
                 :|.|..|.:|.        .|.|....:..:..|.                ||::   ..
 Frog   465 -----EFERERSSEDF--------SQLPTTSESCDFDDPK----------------LFQN---IE 497

  Fly   694 RESYAAPTFTRQPTILVRAES-QRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDE 757
            .:|....|.....|:|....: ...|:|     .|:.||||||||.|||:....||..:||...:
 Frog   498 NDSPTGDTIKEFLTLLAVCHTVVPEKDE-----DTIIYQASSPDEGALVKGARKLGYTFTGRTPD 557

  Fly   758 TLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPL 822
            ::.:.            |..:|::|:.|:||||:|:|||||||||...|...:|.|||::.:|..
 Frog   558 SVIID------------AMGKEQSFELLNVLEFSSNRKRMSVIVRTPSGNLRLYCKGADNVIFER 610

  Fly   823 CANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYA 887
            .:..| :.:.:|..|:..||..|||||.:|...:.:.||:.:|...::|:..:::|.|..||||.
 Frog   611 LSRES-KYMEQTLNHLEQFASEGLRTLCLAYCDLQDSEYEAWLNVHSEASVVIKDRAQKLEECYE 674

  Fly   888 KIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYF 952
            .||.:|.||||||:||.||..|.:|:.:|..|.||||||||||.|||:||..||..:........
 Frog   675 IIEKDLMLLGATAIEDRLQGGVPETIATLMKAEIKIWVLTGDKQETAVNIGYSCRLVSQTMSLIV 739

  Fly   953 IMECK---NREEMLLHLNALDREIIFGIGQE--CALLIDGKSLGVALA-EASSEFRDVAVKCTAV 1011
            :.|..   .|..:..|...|..    |:|:|  .||:|||::|..||: |....|.|:|:.|.||
 Frog   740 VNEDSLDATRSTLTNHCTNLGD----GLGKENDLALIIDGQTLKYALSFEVRQSFLDLALSCKAV 800

  Fly  1012 LCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFA 1076
            :|||:|||||||:|.::| .:.|..|.:||||||||.|||.||||:||.|.||.||...:|:|.|
 Frog   801 ICCRVSPLQKSEIVDMVK-KHVNAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIA 864

  Fly  1077 KFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIY 1141
            :||.|::||||||.:...|::..:||.||||:|...|...|.....||...:::...:.|||||:
 Frog   865 QFCYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAVVNGFSGQVLFERWCIGLYNVIF 929

  Fly  1142 TSLPILFIAISEKPYTEEKLMRTPQLYK--KNTD--NKQLHWPYFLMWVLFAIYHSVIIFYFAFC 1202
            |:||...:.|.|:..:::.::|.|||||  :|.|  |.::.|.:    .:.|:.||:|:|:|...
 Frog   930 TALPPFTLGICERSCSQDSMLRFPQLYKITQNADGFNTRVFWGH----CINALIHSIILFWFPLK 990

  Fly  1203 FFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIY 1267
            ...::.|..| ||...:...|.::...|||.|.||..||:   :.|..|: .:::.|.::..:::
 Frog   991 MLEHDAVFTN-GQVTDYLFVGNIVYTYVVVTVCLKAGLET---TAWTKFS-HLAVWGSMLMWLVF 1050

  Fly  1268 NVINLDYDTDIYWAYNNLLASLPV-----------------WLWIIVTCVACLVPDYTIR 1310
                       :.||:.:..::|:                 ||.:::...|||:.|.|.|
 Frog  1051 -----------FGAYSAIWPTIPIAPDMLGQAGMVLTSGYFWLGLLLVPTACLLRDVTWR 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	404/1278 (32%)
atp8a2	XP_012813389.2	ATPase-Plipid	78..1115	CDD:273734	404/1285 (31%)