Protein Alignment CG4301 and ATP9A

DIOPT Version :9

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: NP_006036.1
• Gene: ATP9A / 10079
• HGNCID: 13540
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1301
• Identity: 347/1301 - (26%)
• Similarity: 566/1301 - (43%)
• Gaps: 314/1301 - (24%)

  Fly    53 DWLQ-----------IQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVM 106
            :||:           :.:|.|:...::.|:  |.|.:.||...||||..|..||:...|.|||::
Human    26 EWLRCCGGGEARPRTVWLGHPEKRDQRYPR--NVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLL 88

  Fly   107 TIISLLIDSPVSPM-TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQ 170
            .....:.:..:..: |..:||.||:|||..::..|:|..|..|..|||...:.:.......:||.
Human    89 ACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSS 153

  Fly   171 DVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITTANLDGESNLKTLMVP----RDLPT-VDLP 230
            ::..|:||:||::..||.|::.||:::.:|.||:.|..||||::.| |.:|    :.||| .||.
Human   154 NIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWK-LRLPVACTQRLPTAADLL 217

  Fly   231 EMHKLGIIECESPTTDLYSFNGKIELKGGEGRVL-PLSTENVLLRGSRVKNTECVIGCAVYTGMI 294
            ::.  ..:..|.|..|:::|.|....:..:..:. .||.||.|..|: |..:..|:|..:|||..
Human   218 QIR--SYVYAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGT-VVASGTVVGVVLYTGRE 279

  Fly   295 SKLQLNSRLTRNKNASSETYINRFLIVILVALIAI----VTLLYFLKRYNELFVIPKLTYLGDAT 355
            .:..:|:...|:|....:..:|....::..||:.:    |.|.:|..|:
Human   280 LRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRW---------------- 328

  Fly   356 DSYSVKQFLQDYLSFLILFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLN 420
                   :|| .:.||:||:.:|||||.|.:::.:::.||.:..|.::      ...||.:|.:.
Human   329 -------YLQ-IIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKI------PGTVVRSSTIP 379

  Fly   421 EELGQINILFSDKTGTLTKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQA 485
            |:||:|:.|.:|||||||:|||            :||:..|
Human   380 EQLGRISYLLTDKTGTLTQNEM------------IFKRLHL------------------------ 408

  Fly   486 LSICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNS 550
                .||.....|:::..:                .::||  .|::|.:...|.    |.|:...
Human   409 ----GTVAYGLDSMDEVQS----------------HIFSI--YTQQSQDPPAQK----GPTLTTK 447

  Fly   551 VSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDP 615
            |                             ||            ..|:|::....:....:...|
Human   448 V-----------------------------RR------------TMSSRVHEAVKAIALCHNVTP 471

  Fly   616 NTVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTP 680
            ...:|||..            ::.:||..:.|...
Human   472 VYESNGVTD------------QAEAEKQYEDSCRV------------------------------ 494

  Fly   681 PAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACA 745
                                                             ||||||||.|||:...
Human   495 -------------------------------------------------YQASSPDEVALVQWTE 510

  Fly   746 NLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE--TFQRLHVLEFTSDRKRMSVIVRD-TDGK 807
            ::|:...|.|..::::|             .|.::  .|..|.:..||.:.|||.:|||| :.|:
Human   511 SVGLTLVGRDQSSMQLR-------------TPGDQILNFTILQIFPFTYESKRMGIIVRDESTGE 562

  Fly   808 KWIYTKGAESYVFPLCANSSAELVTKTD---AHISDFARLGLRTLAIARRLISEEEYQDFLVELA 869
            ...|.|||:..:        |.:|...|   ....:.||.|||.|.:|::.::||:||||.....
Human   563 ITFYMKGADVVM--------AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYV 619

  Fly   870 QANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETA 934
            ||..|:.:|..........:|..::||..|.|||.||.||..||.:|:.||||:|:|||||:|||
Human   620 QAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETA 684

  Fly   935 LNIALSCGHIPPDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASS 999
            ...|.:...:..:...:......||.|..|.|||..|:      .:|||:|.|.||.|.|.....
Human   685 TCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRK------HDCALVISGDSLEVCLKYYEY 743

  Fly  1000 EFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREG 1064
            ||.::|.:|.||:|||.:|.||:::|.|::...... |.::|||.||||||||:..|:|:.|:||
Human   744 EFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKL-TCAVGDGGNDVSMIQESDCGVGVEGKEG 807

  Fly  1065 RQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVY 1129
            :||:..|||:..:|..|.|||:|||.....|.:.|..:..::::....:..:|.....|:|..:|
Human   808 KQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLY 872

  Fly  1130 DSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSV 1194
            ....:..|:.|||..|: |..:.:|....|..|..|:|||.....:.|.:..||:|||.:||...
Human   873 QGFLIIGYSTIYTMFPV-FSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGS 936

  Fly  1195 IIFYFAFCFFYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTI--IISI 1257
            .|.|.|...|....|     ..||.|....:|...::|.:.::.|       .| :.|:  ::|:
Human   937 TIMYGALLLFESEFV-----HIVAISFTSLILTELLMVALTIQTW-------HW-LMTVAELLSL 988

  Fly  1258 LGFVVTTVIYNVINLDYDTDIYWAYNNLLASLP-VWLWIIVTCVACLVPDYTIRMLQRALNIKSF 1321
            ..::.:.|.     |....|:|:     :|:|. :|...::|.|:|| |.|.::.|:|..:..|:
Human   989 ACYIASLVF-----LHEFIDVYF-----IATLSFLWKVSVITLVSCL-PLYVLKYLRRRFSPPSY 1042

  Fly  1322 S 1322
            |
Human  1043 S 1043

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	18/64 (28%)
		ATPase-Plipid	74..1317	CDD:273734	340/1262 (27%)
		E1-E2_ATPase	127..>345	CDD:278548	67/227 (30%)
		Cation_ATPase	<734..823	CDD:289987	28/91 (31%)
		HAD_like	<1036..1066	CDD:304363	17/29 (59%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	67/251 (27%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	320/1175 (27%)
		Cation_ATPase	464..571	CDD:404183	38/210 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144889
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850