DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp11c

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_004917005.2	Gene:	atp11c / 100498300	XenbaseID:	XB-GENE-976439	Length:	1149	Species:	Xenopus tropicalis

Alignment Length:	1354	Identity:	435/1354 - (32%)
Similarity:	667/1354 - (49%)	Gaps:	317/1354 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RLGAHRQTPWADQESFHLKDAFLWNWHKGSRVSTINDWLQIQIGGPQDIKKK----RPK-GQNRI 76
            |||..|..|..:                 :||.|...::     ||:...:.    :|| ..|||
Frog     3 RLGCSRLCPGEE-----------------NRVGTRTVYV-----GPRSASETDAYIQPKFCDNRI 45

  Fly    77 KSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSPMTSLLPLVFVIAVTAAKQGYED 141
            .|:|||:..|:|:||.||||||||||||::.:|..::|:|.||:||.|||.|||.|||.||||||
Frog    46 VSSKYTIWNFIPKNLFEQFRRIANFYFLIIFLIQAIVDTPTSPVTSGLPLFFVITVTAIKQGYED 110

  Fly   142 ILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKCFITT 206
            .||:|.|:.||.|.|.||...|....:|:.:..|:::.|..:...|||||:|.::...|.|.:||
Frog   111 WLRHRADHEVNKSTVYVIEGSKCVKKESEKIKVGDIVEVRDNETFPCDLVMLSTSCRDGTCTVTT 175

  Fly   207 ANLDGESNLKTL-MVPRDLPTVDLPEMHKL-GIIECESPTTDLYSFNGKIELKGGEG-RVLPLST 268
            |:||||||.||. .||.........:::.. ..||||.|..|||.|:|:|::...:. :...|..
Frog   176 ASLDGESNFKTYHAVPETAILATYEDLNAFSATIECEQPQPDLYKFHGRIDVNTNQDVKARSLGP 240

  Fly   269 ENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINRFLIVILVALIAIVTLL 333
            ||:||:|:.:|||:.:.|.||||||.:|:.||.:....|.::.|..||.||||.|..|::..|:.
Frog   241 ENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKRSAVEKSINAFLIVYLCILVSKATIC 305

  Fly   334 YFLKR------------YNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTI 386
            ..||.            |||.....|        :::.:.:...|:|||::|||::||:|:|||:
Frog   306 TSLKYLWQSNPANDEPWYNEKTRKEK--------EAFKILKMFTDFLSFMVLFNFIIPVSMYVTV 362

  Fly   387 ELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSING 451
            |:|:.:||:|:.||:|:::.|.::..:||||:|||||||:..:|:|||||||:|:|.|.:|.|:|
Frog   363 EMQKFLGSFFIAWDMEMFDEEINEGALVNTSDLNEELGQVEYVFTDKTGTLTENKMEFIECCIDG 427

  Fly   452 NKFLFKKTRLED--EETKALLDINKFSAN-QRVFFQALSICHTVQVASGSLEQADAGTAKREPVT 513
            :|  :..|...|  ..|..|....|.|.: :.:|.:||.:|||||
Frog   428 HK--YANTDAMDGLSLTDGLAYFGKASQDLEELFLRALCLCHTVQ-------------------- 470

  Fly   514 AIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYG 578
                          :.||.|
Frog   471 --------------MKEECH--------------------------------------------- 476

  Fly   579 VERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKD 643
                                                    |:|
Frog   477 ----------------------------------------TDG---------------------- 479

  Fly   644 LQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTI 708
                                                         ||.:|.::.|
Frog   480 ---------------------------------------------PSFSSTDNCA---------- 489

  Fly   709 LVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRP 773
                                 |.:|||||.|||......|..|.|.::..:.|.
Frog   490 ---------------------YISSSPDEIALVTGAKRYGFTYMGTENNVMSVE----------- 522

  Fly   774 FAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHI 838
            ..|...|.:|.||||.|...|:||||:|:...||.:::.|||:|.:||..|.   :.|.:...|:
Frog   523 NQKNEIERYQLLHVLNFDPVRRRMSVLVKAKTGKIFLFCKGADSSMFPRVAR---DQVQRIKVHV 584

  Fly   839 SDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVED 903
            ...|..|.|||.:|.:.:|:|.|::...:|.:|..:|::|::...:.|..||:::.|||||||||
Frog   585 EKNALDGYRTLCVAFKEVSQELYENINKQLEEAKLALQDREERLAKVYDDIEADMHLLGATAVED 649

  Fly   904 ALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHI----------PPDAKKYFIMECKN 958
            .||:..|:|:.:|.|||:|:|||||||:|||.:...:|...          ..|.::|...|.:.
Frog   650 RLQEQAAETIEALHAAGMKVWVLTGDKLETAKSTCYACRLFQSNTELLELTTKDLEEYERKEDRL 714

  Fly   959 REEMLLHLNALDREI---------IFGIGQECALLIDGKSLGVALAE--ASSEFRDVAV----KC 1008
            :|.::.:...|.:|.         .:...|:..|:|||.:|.:.|..  :||.::::.:    ||
Frog   715 QELLMEYHRKLVQEAPKLKGGANRSWTGNQDHGLIIDGATLSLILNSNCSSSHYKNIFLQICQKC 779

  Fly  1009 TAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADF 1073
            :||||||::||||:::|.::|::..:..|.|:||||||||||.||||||||.|:|||||||.:|:
Frog   780 SAVLCCRMAPLQKAQIVKMVKNTKGSPITLSVGDGANDVSMILEAHVGIGIKGKEGRQAARSSDY 844

  Fly  1074 AFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYN 1138
            |..||..|::|||.|||.:.||::.||.||||||:.|:...||:||...||...:||:.:||:||
Frog   845 AVPKFKHLRKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYN 909

  Fly  1139 VIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCF 1203
            :.:||:|||..::.|:....|.|...|:||.:.:||..|.|..||.|.|...:.. ::|:|...|
Frog   910 ICFTSMPILAYSLLEQRINIEILSSNPKLYMRISDNAMLQWGPFLYWTLLGAFEG-LVFFFGVYF 973

  Fly  1204 FYYNNVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISILGFVVTTVIYN 1268
            .:.|..|...||......|||::...:|..|.|||.|::.|.::.....|..|:..:|:.::.:.
Frog   974 LFQNPALEGNGQVYGNWSFGTMVFTILVFTVTLKLALDTRYWTWMNHLAIWGSLAFYVIFSLFWG 1038

  Fly  1269 VINLDY--DTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKS 1320
            .|...:  ...:|:.::::|.|:.:||.||:.....|.|:..:.:::   |:|:
Frog  1039 GIIWPFLKQQRMYFVFSHILTSVSIWLGIILLIFVSLYPEIVLILVK---NLKT 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	32/68 (47%)
		ATPase-Plipid	74..1317	CDD:273734	421/1287 (33%)
		E1-E2_ATPase	127..>345	CDD:278548	93/232 (40%)
		Cation_ATPase	<734..823	CDD:289987	33/88 (38%)
		HAD_like	<1036..1066	CDD:304363	23/29 (79%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	85/250 (34%)
atp11c	XP_004917005.2	P-type_ATPase_APLT_Dnf-like	42..971	CDD:319770	393/1170 (34%)
atp11c	XP_004917005.2	7TMR-DISM_7TM	954..>1071	CDD:377898	31/117 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	215	1.000	Domainoid score	I2659
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	795	1.000	Inparanoid score	I498
OMA	1	1.010	-	-		QHG52404
OrthoDB	1	1.010	-	-		D185990at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.080