DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp9b

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_002936489.3	Gene:	atp9b / 100497381	XenbaseID:	XB-GENE-1012387	Length:	1256	Species:	Xenopus tropicalis

Alignment Length:	1292	Identity:	362/1292 - (28%)
Similarity:	566/1292 - (43%)	Gaps:	289/1292 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 WLQIQIGGPQDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVS 118
            ||    |.|:..::|.|:  |.||:.||.:.||:|..|.:||:...|.||||:.....:....:.
Frog   227 WL----GCPEKCEEKYPR--NAIKNQKYNIFTFIPGVLYQQFKFFLNLYFLVVACSQFVSALKIG 285

  Fly   119 PM-TSLLPLVFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVER 182
            .: |...||.||:|||..::..::..|::.|..:||...:.:....:..:||.|:..|:||:||:
Frog   286 YLYTYWAPLGFVLAVTMVREAADEYRRFQRDKEMNSQLYSKLTIRGKVQVKSSDIQVGDLIIVEK 350

  Fly   183 DCDVPCDLVLLRSTDPHGKCFITTANLDGESNLK---TLMVPRDLPTV-DLPEMHKLGIIECESP 243
            :..:|.|:|.||:::..|.|||.|..||||::.|   .:...:.||.: ||..::  ..:..:.|
Frog   351 NQRIPADMVFLRTSEKTGSCFIRTDQLDGETDWKLKIAVSCTQRLPALGDLFSIN--AYVYAQKP 413

  Fly   244 TTDLYSFNGKIELKGGEGRV-LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNK 307
            ..|::||.|....:..:..: ..||.||.|. .|.|..:..|||..:|||..::..:|:...:||
Frog   414 QLDIHSFEGNFTREDTDPSIHESLSIENTLW-ASTVVASGTVIGVVIYTGKETRSVMNTSNPKNK 477

  Fly   308 NASSETYINRFLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLI 372
            ....:..:|:....:.:||:|:..::..|:.    ||.|...||                ..||:
Frog   478 VGMLDLELNQLTKALFLALVALSVVMVTLQG----FVGPWYRYL----------------FRFLL 522

  Fly   373 LFNYLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTL 437
            ||:|:|||||.|.:::.:....|.      :..:|.....||.||.:.||||::..|.:||||||
Frog   523 LFSYIIPISLRVNLDMGKAAYGWM------IMRDENIPGTVVRTSTIPEELGRLVYLLTDKTGTL 581

  Fly   438 TKNEMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQA 502
            |:|||            :||:..|                            .||...:.::::.
Frog   582 TQNEM------------VFKRLHL----------------------------GTVSYGTDTMDEI 606

  Fly   503 DAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDV 567
                                        ::|.||..|.:....:.:|:.||.|:
Frog   607 ----------------------------QNHIASSYSLVQPSQSCNNNTSATPS----------- 632

  Fly   568 NPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPIS 632
                          ||                   |.:|...:.:|..:.|...|      :.|:
Frog   633 --------------RK-------------------GQSSAPKVRKTVSSRVHEAV------KAIA 658

  Fly   633 LQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESY 697
            |                           .|:        ..||..|.  |||
Frog   659 L---------------------------CHN--------VTPVYESR--AGV------------- 673

  Fly   698 AAPTFTRQPTILVRAESQRRKNEI-RDFI-FTLDYQASSPDEKALVEACANLGMVYTGDDDETLR 760
                           ..:...:|: :||. ....||||||||.|||:...::|:.....|..:::
Frog   674 ---------------NGETEYSEVDQDFCDENRTYQASSPDEVALVQWTESVGLTLVNRDLTSMQ 723

  Fly   761 VRIVPPHMDYKRPFAKPREE--TFQRLHVLEFTSDRKRMSVIVR-DTDGKKWIYTKGAESYVFPL 822
            ::             .|..:  ||..|.:..|||:.|||.:||| ::.|....|.|||:.
Frog   724 LK-------------TPGGQILTFCILQIFPFTSESKRMGIIVREESSGDITFYMKGADV----- 770

  Fly   823 CANSSAELVTKT---DAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEE 884
               :.|.:|...   |....:.||.|||||.:|::.:|||:||||.....||..|:.:|......
Frog   771 ---AMATIVQYNDWLDEECGNMAREGLRTLVVAKKSLSEEQYQDFENRYNQAKLSMHDRALKVAA 832

  Fly   885 CYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAK 949
            ....:|..::||..|.|||.||.||..||..|:.||||||:|||||:|||..||.|...:..:..
Frog   833 VVESLEREMELLCLTGVEDQLQTDVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRNQD 897

  Fly   950 KYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVALAEASSEFRDVAVKCTAVLCC 1014
            .:......||.|..|.|||..|:      .:|||:|.|.||.|.|.....||.::|.:|.||:||
Frog   898 IHIFRPVSNRSEAHLELNAFRRK------HDCALVIAGDSLEVCLKYYEHEFVELACQCPAVVCC 956

  Fly  1015 RLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFC 1079
            |.||.||:.:|.|:: .:....|.:||||.|||||||.|..||||.|:||:||:..|||:..:|.
Frog   957 RCSPTQKAHIVKLLQ-QHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFK 1020

  Fly  1080 MLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSL 1144
            .:.|||:|||.....|.:.|..:..::.:|...:..:|.....|:|..:|....:..|..|||..
Frog  1021 HIGRLLMVHGRNSYKRSAALGQFVIHRGLVISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMF 1085

  Fly  1145 PILFIAISE--KPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYN 1207
            |:..:.:.:  ||   |..:..|:|||..|..:.|.:..||:|||.:||...|:.:.|...|...
Frog  1086 PVFSLVLDQDVKP---ETALLYPELYKDLTKGRSLSFKTFLIWVLISIYQGGILMFGALVLFESE 1147

  Fly  1208 NVLLNYGQTVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFW-YIFTIIISILGFVVTTVIYNV-- 1269
            .|     ..||.|....:|...::|.:.::.|       .| .:...:.|:..:|.:....|.
Frog  1148 FV-----HVVAISFTALILTELLMVALTIRTW-------HWLMVVAELFSLASYVASLAFLNEYF 1200

  Fly  1270 ----INLDYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFS 1322
                ::|....|.  |:...|..|  |..:.:|.|:|| |.|.::.|:|..:..|:|
Frog  1201 GLGRVSLGAFLDA--AFITTLTFL--WKVLAITVVSCL-PLYILKYLKRKFSPPSYS 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	20/64 (31%)
		ATPase-Plipid	74..1317	CDD:273734	354/1265 (28%)
		E1-E2_ATPase	127..>345	CDD:278548	63/222 (28%)
		Cation_ATPase	<734..823	CDD:289987	27/91 (30%)
		HAD_like	<1036..1066	CDD:304363	20/29 (69%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	66/257 (26%)
atp9b	XP_002936489.3	P-type_ATPase_APLT_Neo1-like	240..1165	CDD:319841	334/1174 (28%)
atp9b	XP_002936489.3	Cation_ATPase	658..769	CDD:404183	41/188 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920