DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp10b

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_002940174.2	Gene:	atp10b / 100489696	XenbaseID:	XB-GENE-6045964	Length:	1443	Species:	Xenopus tropicalis

Alignment Length:	1441	Identity:	442/1441 - (30%)
Similarity:	689/1441 - (47%)	Gaps:	254/1441 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DAFLWNW-----HKGSRVST-INDWLQIQIGGPQ-DIKKKR-------------------PKGQN 74
            |:.|:.|     :..|:.|: ....|..:..||. ::||:|                   .|| |
Frog     2 DSSLYRWTHVAQNSSSKCSSETTPLLPPKRKGPSYNLKKERIVFANNKTYERDWKAVSRYYKG-N 65

  Fly    75 RIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPV-SPMTSLLPLVFVIAVTAAKQG 138
            :|::|||||::|||:||.|||.|.||.||:.:..::.:....| ....:::||..|:.|.|.|..
Frog    66 KIRTTKYTLLSFLPKNLFEQFYRSANIYFVFLAALNWVPQIGVFHKEITMVPLAIVLGVIAIKDA 130

  Fly   139 YEDILRYRTDNVVNSSPVTVIRDGKEAIIKS--QDVIPGELIVVERDCDVPCDLVLLRSTDPHGK 201
            .||..|||.|..:|.:..:|........::.  :||..|:.:.:..:..:|.|::||..:|.:|.
Frog   131 VEDYKRYRIDRRINFTKTSVYNKNSNDFVEKCWKDVCVGDFVKLLCNEIIPADILLLFCSDQNGI 195

  Fly   202 CFITTANLDGESNLKTLMVPRDLPTVDL---PEMHKLGIIECESPTTDLYSFNGKIELKGGEGRV 263
            |.|.|||||||:|||...|.:......:   ||..:..|: ||.|..:|..|.|.::|..|:.
Frog   196 CHIETANLDGETNLKQRQVVKGFCKQGMAFDPESFRNTIV-CEKPNNNLNKFKGYMQLDNGQR-- 257

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYIN---RFLIVILVA 325
            .....|::||||..|:|||.|:|..||.|..:|..||:...|.|.:..|..:|   .|.:.||..
Frog   258 TGFGNESLLLRGCTVRNTEEVVGIVVYAGHETKAMLNNSGPRYKRSKIERQMNINVFFCVGILFI 322

  Fly   326 LIAIVTLLYFLKRYNELFVIPKLTYLGDATDSY---SVKQFLQDYLSFLILFNYLIPISLYVTIE 387
            :..|..|.|.:  :...||||.|..:.:|..||   ::..|.. :|:.:||...||||||||:||
Frog   323 MCLIGALGYGI--WTSKFVIPPLFDVPEADGSYLSPALAGFYM-FLTMIILLQILIPISLYVSIE 384

  Fly   388 LQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGN 452
            |.::...:.:..||:||:.|.|........|:.|:||||..:|||||||||:|:|.|::|:|.|.
Frog   385 LVKLGQIYLIHSDLDLYDEEIDLSVQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGY 449

  Fly   453 KF----------LFKKTRLEDEE-TKA---LLDINKFSANQRVF----FQALSICHTV------- 492
            :|          ::.:...:||: ||.   |.|::  :.||...    .:||..||:.
Frog   450 EFSHQENAKRLEMYNEEESDDEDMTKPRNFLFDLD--AGNQSTVRHKGTKALRRCHSARPNIQGH 512

  Fly   493 ------------QVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQS------ 539
                        |||..|..:.|. |.....:..::....:..::|.:..:|:..:..|
Frog   513 FRKKSEGRFDISQVAFSSPIEKDV-TPDHMLLAKVREASVKFAAVSPLVSQSNIRAASSPYIDFF 576

  Fly   540 -ELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNG 603
             .|.:.:|:..|.:..|. ...||      |.|:...|..:|        |....|.|...::..
Frog   577 LALAICNTVVVSTATEPR-QRVTI------PPLLKSSGSSLE--------KFQHLFQRLKLLSFS 626

  Fly   604 AASDLNINQTDPNTVT----NGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSY 664
            .:|..:.:.:||.|.|    |.|.|.            .:::||...|  :.||:|    ...|.
Frog   627 QSSSTSPSSSDPGTPTSSKNNKVSPV------------PSADKDNISS--SSSGEA----ECQSS 673

  Fly   665 GAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLD 729
            |                     :..|:.|:.|                    ..|.:.:.|.|:.
Frog   674 G---------------------KDDSSVSKNS--------------------ADNCLEEMIATVS 697

  Fly   730 ---------YQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE--TFQ 783
                     |:|.||||.|||.|.............:.:.||:             |:..  ||.
Frog   698 SLHIEDDFCYEAESPDEAALVHAARAYSFTLMSRTPDQVTVRL-------------PQGTLLTFD 749

  Fly   784 RLHVLEFTSDRKRMSVIVRDTDGKKWI-YTKGAESYVF-----PLCANSSAE-----LVTKTDAH 837
            .|:.|.|.|.||||||:||....::.| |||||:|.:.     |..||.|.|     :..:|..|
Frog   750 LLYTLGFDSVRKRMSVVVRHPITREIIVYTKGADSVIMDLLDDPSKANISDEKKLRKMQARTQRH 814

  Fly   838 ISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVE 902
            :..:||.|||||.||::::||:|::.:.....:|.:::|||::|..|....:|:||.|||||.:|
Frog   815 LDWYARDGLRTLCIAKKVLSEDEFERWSNFREEAEAAIENREELLMETAQHLETNLSLLGATGIE 879

  Fly   903 DALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIP---------------------- 945
            |.||:.|.||:.||:.|||.||||||||.|||:|||.||..:.
Frog   880 DRLQEGVPDTIASLREAGINIWVLTGDKQETAVNIAYSCQLLDQYDTVFTINTESKETCESILDC 944

  Fly   946 --PDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVAL-AEASSEFRDVAVK 1007
              .|.||:|  ..|.:..:.....|.....:..:..:..|:|||::|.|.. ....::|.:::..
Frog   945 TLEDVKKFF--PEKKKRGLFKRSKAPVSHELEAVRPQVGLVIDGRTLNVIFQGGLETKFLELSRH 1007

  Fly  1008 CTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCAD 1072
            |.:|||||.:|||||.||.|::...: ..|.|||||||||||||.|.:||||.|:||.||...:|
Frog  1008 CRSVLCCRATPLQKSMVVKLVRDKLK-VMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSD 1071

  Fly  1073 FAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLY 1137
            ||.::|..||:|||||||:...||:.:|:||||||:.::.::|.:|....||.:::.|...:..:
Frog  1072 FAISRFKHLKKLLLVHGHWCYTRLANMVIYFFYKNVAYVNLLFWYQLFCGFSGTTMIDYWQMIFF 1136

  Fly  1138 NVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFC 1202
            |:.:||:|.|...|.:|..:.|.||..|.|||.....|......|.:.::.|.|.|::.|:..
Frog  1137 NLFFTSVPPLVFGILDKDISAETLMSLPHLYKSGQQCKSYKMSTFWIAIVDAFYQSLVCFFIP-- 1199

  Fly  1203 FFYYNNV---LLNYGQTVAFSCFGTLLMWTVV--VVVNLKLWLESMYLSFWYIFTIIISILGFVV 1262
            :|.|...   :|::|..:     .|:.::|::  :.:.:|.|.    :..|  .||::||:.:.|
Frog  1200 YFTYQGTDIDVLSFGTPI-----NTIALFTILMHLAIEIKTWT----ILHW--VTIVVSIICYFV 1253

  Fly  1263 TTVIYNVINL--DYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFP 1325
            .::.||.|.:  :...:.||.....::....::..|:|.|..|:|.|.||.| |...:.:..|..
Frog  1254 VSLAYNAICVLCNEPANPYWIMEMQMSDPLFYIVCIITPVIALLPRYFIRAL-RGTCVANPLILA 1317

  Fly  1326 GKQRKLKMREK 1336
            .|..||...|:
Frog  1318 QKLDKLGKEER 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	28/84 (33%)
		ATPase-Plipid	74..1317	CDD:273734	424/1356 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	73/225 (32%)
		Cation_ATPase	<734..823	CDD:289987	33/96 (34%)
		HAD_like	<1036..1066	CDD:304363	22/29 (76%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/255 (30%)
atp10b	XP_002940174.2	P-type_ATPase_APLT_Dnf-like	64..1199	CDD:319770	396/1234 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48106
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920