Protein Alignment CG4301 and atp10b

DIOPT Version :10

• Sequence 1: NP_573125.1
• Gene: CG4301 / 32610
• FlyBaseID: FBgn0030747
• Length: 1342
• Species: Drosophila melanogaster
• Sequence 2: XP_002940174.2
• Gene: atp10b / 100489696
• XenbaseID: XB-GENE-6045964
• Length: 1443
• Species: Xenopus tropicalis
• Alignment Length: 1441
• Identity: 442/1441 - (30%)
• Similarity: 689/1441 - (47%)
• Gaps: 254/1441 - (17%)

  Fly    36 DAFLWNW-----HKGSRVST-INDWLQIQIGGPQ-DIKKKR-------------------PKGQN 74
            |:.|:.|     :..|:.|: ....|..:..||. ::||:|                   .|| |
 Frog     2 DSSLYRWTHVAQNSSSKCSSETTPLLPPKRKGPSYNLKKERIVFANNKTYERDWKAVSRYYKG-N 65

  Fly    75 RIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPV-SPMTSLLPLVFVIAVTAAKQG 138
            :|::|||||::|||:||.|||.|.||.||:.:..::.:....| ....:::||..|:.|.|.|..
 Frog    66 KIRTTKYTLLSFLPKNLFEQFYRSANIYFVFLAALNWVPQIGVFHKEITMVPLAIVLGVIAIKDA 130

  Fly   139 YEDILRYRTDNVVNSSPVTVIRDGKEAIIKS--QDVIPGELIVVERDCDVPCDLVLLRSTDPHGK 201
            .||..|||.|..:|.:..:|........::.  :||..|:.:.:..:..:|.|::||..:|.:|.
 Frog   131 VEDYKRYRIDRRINFTKTSVYNKNSNDFVEKCWKDVCVGDFVKLLCNEIIPADILLLFCSDQNGI 195

  Fly   202 CFITTANLDGESNLKTLMVPRDLPTVDL---PEMHKLGIIECESPTTDLYSFNGKIELKGGEGRV 263
            |.|.|||||||:|||...|.:......:   ||..:..|: ||.|..:|..|.|.::|..|:.
 Frog   196 CHIETANLDGETNLKQRQVVKGFCKQGMAFDPESFRNTIV-CEKPNNNLNKFKGYMQLDNGQR-- 257

  Fly   264 LPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYIN---RFLIVILVA 325
            .....|::||||..|:|||.|:|..||.|..:|..||:...|.|.:..|..:|   .|.:.||..
 Frog   258 TGFGNESLLLRGCTVRNTEEVVGIVVYAGHETKAMLNNSGPRYKRSKIERQMNINVFFCVGILFI 322

  Fly   326 LIAIVTLLYFLKRYNELFVIPKLTYLGDATDSY---SVKQFLQDYLSFLILFNYLIPISLYVTIE 387
            :..|..|.|.:  :...||||.|..:.:|..||   ::..|.. :|:.:||...||||||||:||
 Frog   323 MCLIGALGYGI--WTSKFVIPPLFDVPEADGSYLSPALAGFYM-FLTMIILLQILIPISLYVSIE 384

  Fly   388 LQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGN 452
            |.::...:.:..||:||:.|.|........|:.|:||||..:|||||||||:|:|.|::|:|.|.
 Frog   385 LVKLGQIYLIHSDLDLYDEEIDLSVQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRCTIVGY 449

  Fly   453 KF----------LFKKTRLEDEE-TKA---LLDINKFSANQRVF----FQALSICHTV------- 492
            :|          ::.:...:||: ||.   |.|::  :.||...    .:||..||:.
 Frog   450 EFSHQENAKRLEMYNEEESDDEDMTKPRNFLFDLD--AGNQSTVRHKGTKALRRCHSARPNIQGH 512

  Fly   493 ------------QVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQS------ 539
                        |||..|..:.|. |.....:..::....:..::|.:..:|:..:..|
 Frog   513 FRKKSEGRFDISQVAFSSPIEKDV-TPDHMLLAKVREASVKFAAVSPLVSQSNIRAASSPYIDFF 576

  Fly   540 -ELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNG 603
             .|.:.:|:..|.:..|. ...||      |.|:...|..:|        |....|.|...::..
 Frog   577 LALAICNTVVVSTATEPR-QRVTI------PPLLKSSGSSLE--------KFQHLFQRLKLLSFS 626

  Fly   604 AASDLNINQTDPNTVT----NGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSY 664
            .:|..:.:.:||.|.|    |.|.|.            .:::||...|  :.||:|    ...|.
 Frog   627 QSSSTSPSSSDPGTPTSSKNNKVSPV------------PSADKDNISS--SSSGEA----ECQSS 673

  Fly   665 GAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLD 729
            |                     :..|:.|:.|                    ..|.:.:.|.|:.
 Frog   674 G---------------------KDDSSVSKNS--------------------ADNCLEEMIATVS 697

  Fly   730 ---------YQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREE--TFQ 783
                     |:|.||||.|||.|.............:.:.||:             |:..  ||.
 Frog   698 SLHIEDDFCYEAESPDEAALVHAARAYSFTLMSRTPDQVTVRL-------------PQGTLLTFD 749

  Fly   784 RLHVLEFTSDRKRMSVIVRDTDGKKWI-YTKGAESYVF-----PLCANSSAE-----LVTKTDAH 837
            .|:.|.|.|.||||||:||....::.| |||||:|.:.     |..||.|.|     :..:|..|
 Frog   750 LLYTLGFDSVRKRMSVVVRHPITREIIVYTKGADSVIMDLLDDPSKANISDEKKLRKMQARTQRH 814

  Fly   838 ISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVE 902
            :..:||.|||||.||::::||:|::.:.....:|.:::|||::|..|....:|:||.|||||.:|
 Frog   815 LDWYARDGLRTLCIAKKVLSEDEFERWSNFREEAEAAIENREELLMETAQHLETNLSLLGATGIE 879

  Fly   903 DALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIP---------------------- 945
            |.||:.|.||:.||:.|||.||||||||.|||:|||.||..:.
 Frog   880 DRLQEGVPDTIASLREAGINIWVLTGDKQETAVNIAYSCQLLDQYDTVFTINTESKETCESILDC 944

  Fly   946 --PDAKKYFIMECKNREEMLLHLNALDREIIFGIGQECALLIDGKSLGVAL-AEASSEFRDVAVK 1007
              .|.||:|  ..|.:..:.....|.....:..:..:..|:|||::|.|.. ....::|.:::..
 Frog   945 TLEDVKKFF--PEKKKRGLFKRSKAPVSHELEAVRPQVGLVIDGRTLNVIFQGGLETKFLELSRH 1007

  Fly  1008 CTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCAD 1072
            |.:|||||.:|||||.||.|::...: ..|.|||||||||||||.|.:||||.|:||.||...:|
 Frog  1008 CRSVLCCRATPLQKSMVVKLVRDKLK-VMTLSIGDGANDVSMIQAADIGIGISGQEGMQAVMSSD 1071

  Fly  1073 FAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLY 1137
            ||.::|..||:|||||||:...||:.:|:||||||:.::.::|.:|....||.:::.|...:..:
 Frog  1072 FAISRFKHLKKLLLVHGHWCYTRLANMVIYFFYKNVAYVNLLFWYQLFCGFSGTTMIDYWQMIFF 1136

  Fly  1138 NVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFC 1202
            |:.:||:|.|...|.:|..:.|.||..|.|||.....|......|.:.::.|.|.|::.|:..
 Frog  1137 NLFFTSVPPLVFGILDKDISAETLMSLPHLYKSGQQCKSYKMSTFWIAIVDAFYQSLVCFFIP-- 1199

  Fly  1203 FFYYNNV---LLNYGQTVAFSCFGTLLMWTVV--VVVNLKLWLESMYLSFWYIFTIIISILGFVV 1262
            :|.|...   :|::|..:     .|:.::|::  :.:.:|.|.    :..|  .||::||:.:.|
 Frog  1200 YFTYQGTDIDVLSFGTPI-----NTIALFTILMHLAIEIKTWT----ILHW--VTIVVSIICYFV 1253

  Fly  1263 TTVIYNVINL--DYDTDIYWAYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFP 1325
            .::.||.|.:  :...:.||.....::....::..|:|.|..|:|.|.||.| |...:.:..|..
 Frog  1254 VSLAYNAICVLCNEPANPYWIMEMQMSDPLFYIVCIITPVIALLPRYFIRAL-RGTCVANPLILA 1317

  Fly  1326 GKQRKLKMREK 1336
            .|..||...|:
 Frog  1318 QKLDKLGKEER 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	Haloacid Dehalogenase-like Hydrolases	74..1317	CDD:473868	424/1356 (31%)
atp10b	XP_002940174.2	P-type_ATPase_APLT_Dnf-like	64..1199	CDD:319770	396/1234 (32%)