DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8a2

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_017209427.1	Gene:	atp8a2 / 100330943	ZFINID:	ZDB-GENE-100209-2	Length:	1211	Species:	Danio rerio

Alignment Length:	1291	Identity:	405/1291 - (31%)
Similarity:	614/1291 - (47%)	Gaps:	283/1291 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 NRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPLVFVIAVTAAKQ 137
            |.:.:.||.::||||:.|.||.||.||.:||.:.::..:.| ||....|:|:||:|::.|...|:
Zfish    94 NHVSTAKYGILTFLPRFLYEQIRRAANAFFLFIALMQQIPDVSPTGRYTTLVPLIFILTVAGIKE 158

  Fly   138 GYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLLRSTDPHGKC 202
            ..||..|::.||.||....||:|:|....|..:.|..|:::.|.....:|.|:|::.|::|...|
Zfish   159 IIEDYKRHKADNTVNKKKTTVLRNGAWQTIIWKQVAVGDIVKVTNGQHLPADMVIVSSSEPQAMC 223

  Fly   203 FITTANLDGESNLKTLMVPRDLP-TVDLPEMHKL----GIIECESPTTDLYSFNGKIELKGGEGR 262
            :..|:|||||:|||   :.:.|. |.....:..|    |.:|||.|...||.|.|.:.|  ....
Zfish   224 YTETSNLDGETNLK---IRQGLSLTASFQSLEDLIALSGRLECEGPNRHLYDFTGTLRL--DNHN 283

  Fly   263 VLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR-----FLIVI 322
            ..||..:.|||||::::||:.|:|..||||..|||..||.....|.::.|...|.     |.|::
Zfish   284 PAPLGPDQVLLRGAQLRNTQWVVGIVVYTGHDSKLMQNSTKAPLKRSNVERVTNMQILVLFGILL 348

  Fly   323 LVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISLYVTIE 387
            ::||::.:....:.|::.:    ....||..|.| .|: .|..:.|:|:||:|.||||||.||:|
Zfish   349 VMALVSSIGAAIWNKQHTD----EACWYLSRAGD-ISL-NFAYNLLTFIILYNNLIPISLLVTLE 407

  Fly   388 LQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQCSINGN 452
            :.:...:.|:.||:|:|..|||.|.:..||||||||||:..||||||||||.|.|:|::|:|.|
Zfish   408 VVKFTQALFINWDVEMYYAETDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNVMHFKKCTIAG- 471

  Fly   453 KFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAGTAKREPVTAIKS 517
                                                     :..|.....|...:
Zfish   472 -----------------------------------------ITYGHFPDLDCDRS---------- 485

  Fly   518 GPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPLLVSDDGYGVERR 582
                |...|.:...|||:::                                   .||
Zfish   486 ----MEDFSHLPSTSHNSTE-----------------------------------FDD------- 504

  Fly   583 KRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPISLQFRRSTSEKDLQQS 647
              |.:|:                   ||.:..|.
Zfish   505 --PALIQ-------------------NIEKNHPT------------------------------- 517

  Fly   648 WEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPSTTSRESYAAPTFTRQPTILVRA 712
                                                    ||......:..|...|..|
Zfish   518 ----------------------------------------SPQICEFLTMMAVCHTVVP------ 536

  Fly   713 ESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDETLRVRIVPPHMDYKRPFAKP 777
              :|..|:|       .||||||||.|||:...:||.|:|.....::.:.            |:.
Zfish   537 --EREDNQI-------IYQASSPDEGALVKGAKSLGFVFTARTPHSVIIE------------ARG 580

  Fly   778 REETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESYVFPLCANSSAELVTKTDAHISDFA 842
            :|:|::.|:||||:|:|||||||||...|...:|.|||::.:|.. .|.:::....|.||:..||
Zfish   581 KEQTYELLNVLEFSSNRKRMSVIVRTPTGNLRLYCKGADNVIFER-LNVTSQYKELTVAHLEQFA 644

  Fly   843 RLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSEECYAKIESNLDLLGATAVEDALQD 907
            ..|||||..|...:.|..|.::|.|..:.::.|::|.|..||||..||.||.||||||:||.||.
Zfish   645 TEGLRTLCFAYVDLEEGAYLEWLKEYNRISTVLKDRAQKLEECYELIEKNLLLLGATAIEDRLQA 709

  Fly   908 DVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDAKKYFIMECK---NREEMLLHLNAL 969
            .|.:|:.:|..|.||||||||||.|||:||..||..:........:.|..   .|..:..|.::|
Zfish   710 GVPETIATLMRADIKIWVLTGDKQETAINIGYSCRLVSHGMSLIIVNEDSLDATRATLTAHCSSL 774

  Fly   970 D----REIIFGIGQECALLIDGKSLGVALA-EASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIK 1029
            .    :|      .|.||:|||::|..||: |....|.|:|:.|.||:|||:|||||||:|.::|
Zfish   775 GDSLRKE------NELALIIDGQTLKYALSFEVRQAFLDLALSCKAVICCRVSPLQKSEIVDMVK 833

  Fly  1030 SSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSV 1094
             .:....|.:||||||||.|||.||||:||.|.||.||...:|::.|:|..|::||||||.:...
Zfish   834 -KHVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNSSDYSIAQFSYLEKLLLVHGAWSYN 897

  Fly  1095 RLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEE 1159
            |::..:||.||||:|...|...|.|...||...:::...:.|||||:|:||...:.|.::|.:::
Zfish   898 RVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFDRPCSQQ 962

  Fly  1160 KLMRTPQLYK--KNTD--NKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVAFS 1220
            .::|.||||:  :|.:  |.::.|.:    .:.|:.||:|:|:|......::....| |.:|.:.
Zfish   963 NMIRFPQLYRITQNAEGFNTKVFWGH----CINALIHSIILFWFPLKALEHDTPFDN-GNSVDYL 1022

  Fly  1221 CFGTLLMWTVVVVVNLK------LWLESMYLSFWYIFTIIISILGFVVTTVIYNVINLDYDTDIY 1279
            ..|.::...|||.|.||      .|....:|:.|  .::::.:|.|.|.:.|:..|.:  ..|:.
Zfish  1023 FVGNIVYTYVVVTVCLKAGMETTAWTRFSHLAVW--GSMVLWMLFFAVYSAIWPTIPI--APDML 1083

  Fly  1280 WAYNNLLASLPVWLWIIVTCVACLVPDY-------TIR--MLQRALNIKSFSIFPG 1326
            .....::.....||.:|:...|||:.|.       |:|  :|:....:::.::.||
Zfish  1084 GQAGRVMQCWSFWLGLILVPTACLLKDVVWNAGRRTVRKTLLEEVQELEARAVDPG 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	19/47 (40%)
		ATPase-Plipid	74..1317	CDD:273734	403/1280 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	74/227 (33%)
		Cation_ATPase	<734..823	CDD:289987	35/88 (40%)
		HAD_like	<1036..1066	CDD:304363	21/29 (72%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	76/267 (28%)
atp8a2	XP_017209427.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820