DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8b1

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_001920510.4	Gene:	atp8b1 / 100148342	ZFINID:	ZDB-GENE-091116-14	Length:	1249	Species:	Danio rerio

Alignment Length:	1365	Identity:	387/1365 - (28%)
Similarity:	606/1365 - (44%)	Gaps:	354/1365 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 IKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLIDSPVSP-MTSLLPLVF 128
            |||.|..| |.||:.||.::||||.||.|||:|.||.|||.:.::.::......| .|:|:|||.
Zfish    81 IKKSRYSG-NAIKTYKYNVLTFLPLNLYEQFKRAANLYFLCLLVLQIIPQISTLPWYTTLVPLVL 144

  Fly   129 VIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLVLL 193
            |:.:||.|...:|:.|:|.|..:|:....|:.:|:....:..::..|:::.:.::..:|.|::||
Zfish   145 VLGITAIKDLVDDLARHRMDKEINNRKCDVLLNGRFVETRWMNLQVGDVVRLHKNDFIPADIMLL 209

  Fly   194 RSTDPHGKCFITTANLDGESNLKTLMVPRDLPTVD--LPEMHKL----GIIECESPTTDLYSFNG 252
            .:::|:..|::.||.||||:|||..|   .|...|  |.|..:|    .::.||.|...|..|.|
Zfish   210 STSNPNSLCYVETAELDGETNLKFKM---GLKVTDERLQEEQQLSQFNALVMCEEPNNRLDKFVG 271

  Fly   253 KIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYINR 317
            .:.   .|.:...|..:|:||||.:|:||:...|..::.|..:|:..|...||.|....:..:|.
Zfish   272 TMI---WESQSYALDLDNMLLRGCKVRNTDICHGLVIFAGNDTKIMRNGGKTRFKRTRIDKLMNY 333

  Fly   318 FLIVILVALIAIVTLLYFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFNYLIPISL 382
            .:..|.|.|:.:...|.....|....:..|..||.|..|..|..:....:..::|:.|.::||||
Zfish   334 MVYTIFVLLVLLCAGLAIGHTYWYESIGSKAWYLIDGLDYTSSYRGFLSFWGYIIILNTMVPISL 398

  Fly   383 YVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKNEMNFQQC 447
            ||::|:.|:..|.|:.|||::|..:.|.|....|:.|||:||||..:|||||||||:|.|.|::|
Zfish   399 YVSVEVIRLGQSKFINWDLQMYYADKDTPAKSRTTTLNEQLGQIEYIFSDKTGTLTQNIMAFKKC 463

  Fly   448 SING------------------------NKFLFKKTRLEDEETKALLDINKFSANQRV--FFQAL 486
            :|:|                        ||:..:|.:.||.   .|:...:...:.:|  ||:.|
Zfish   464 TISGRTYGEPTTADGVSLDRGKPVDFSWNKYADRKFQFEDH---FLISCIRSKKDPQVLEFFKLL 525

  Fly   487 SICHTVQVASGSLEQADAGTAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSV 551
            |:||||.|
Zfish   526 SLCHTVMV--------------------------------------------------------- 533

  Fly   552 SAHPNGVNSTIISSDVNPLLVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPN 616

Zfish   534 ----------------------------------------------------------------- 533

  Fly   617 TVTNGVEPTTNFRPISLQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPP 681
                                            |...|:
Zfish   534 --------------------------------EEKEGE--------------------------- 539

  Fly   682 AGVLFRSPSTTSRESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACAN 746
                                                          |.|||:||||.|||.|..|
Zfish   540 ----------------------------------------------LVYQAASPDEGALVTAARN 558

  Fly   747 LGMVYTGDDDETLRVRIVPPHMDYKRPFAKPREETFQRLHVLEFTSDRKRMSVIVRDTDGKKWIY 811
            .|.|:.....:|:.::    .||      ||  :|:..|.:|:|.|||||||:|::..||:..:|
Zfish   559 FGFVFLSRTQDTITIQ----EMD------KP--QTYTMLALLDFNSDRKRMSIILKFPDGRIRLY 611

  Fly   812 TKGAESYVFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLE 876
            .|||::.::...:..|.......:| :..||...||||.:..:.||:||:..:..:...|..|:.
Zfish   612 CKGADTVIYQRLSPQSKNKENTQEA-LDIFANETLRTLCLCYKDISQEEFDRWSRKHQTAAVSMV 675

  Fly   877 NRKQLSEECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSC 941
            :|::..:|.|.:||.:|.|:||||:||.|||.|.:|:..|..|.||||||||||.|||.||..||
Zfish   676 DRERELDEVYEEIEKDLLLIGATAIEDKLQDGVPETIAKLAKADIKIWVLTGDKKETAENIGYSC 740

  Fly   942 GHIPPDAKKYF----IMECKNREEML----LHLNALDREIIFGIGQECALLIDGKSLGVALAE-- 996
            ..:..|.|.::    .::.:||:...    ...|...:|..|....:.||:|.|..|...|.|
Zfish   741 QLLTDDMKIHYGEDVNVQLRNRQTQRRTDPQSRNKKQKESFFNEPGKNALIITGGWLNEILYEKK 805

  Fly   997 --------------------ASS-------------------EFRDVAVKCTAVLCCRLSPLQKS 1022
                                :||                   :|.|:|.:|:||:|||::|.||:
Zfish   806 KKRRRLRLKKLRLRQNNQQSSSSTAPDSSQPVDDWEKEKRQEDFVDMACECSAVICCRVTPKQKA 870

  Fly  1023 EVVSLIKSSNENYNTASIGDGANDVSMIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLV 1087
            .||||:|...:.. |.|||||||||:||:.|.:|:||.|:||.||...:|:|||:||.|:|||||
Zfish   871 NVVSLVKKYKKAV-TLSIGDGANDVNMIKTADIGVGISGQEGMQAVMSSDYAFAQFCFLQRLLLV 934

  Fly  1088 HGHYHSVRLSLLVLYFFYKNIVFMGIMFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAIS 1152
            ||.:..:|:...:.||||||..|..:.|.|.|...||:.:.|:..|:|||||.|:|||:|.:.:.
Zfish   935 HGRWSYIRMCKFLRYFFYKNFAFTLVHFWFSFFNGFSAQTAYEDWFITLYNVCYSSLPVLLVGLL 999

  Fly  1153 EKPYTEEKLMRTPQLYKKNTDNKQLHWPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQ-- 1215
            ::...::..:|.|:||.........::..|.:.:...|:.|::||     |..|...|...||
Zfish  1000 DQDVNDKLSLRFPKLYLPGQQGALFNYRNFFISLFHGIFTSLMIF-----FIPYGAFLQTMGQDG 1059

  Fly  1216 --TVAFSCFGTLLMWTVVVVVNLKLWLESMYLSFWYIFTIIISI-LGFVVTTVIYNV-INLDYDT 1276
              ...:..|..:...::::.|||::.|.:.|.:|...|.::.|| |.|.:...|::. |::.:..
Zfish  1060 EAPSDYQSFAVVAASSLIITVNLQISLNTSYWTFVNFFAVLGSIALYFGIMFDIHSAGIHVIFPN 1124

  Fly  1277 DIYW--AYNNLLASLPVWLWIIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKL-KMREKFE 1338
            ...:  |.:|.|....:||.||:|...||:|...|:.|.:       :|:|....|: :.|:|:|
Zfish  1125 TFTFTGAASNALRQPYLWLTIILTVGVCLLPVICIQFLYQ-------TIYPSVGDKVQRNRKKYE 1182

Fly 1339 1338
Zfish 1183 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	26/56 (46%)
		ATPase-Plipid	74..1317	CDD:273734	376/1332 (28%)
		E1-E2_ATPase	127..>345	CDD:278548	63/223 (28%)
		Cation_ATPase	<734..823	CDD:289987	34/88 (39%)
		HAD_like	<1036..1066	CDD:304363	19/29 (66%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	80/256 (31%)
atp8b1	XP_001920510.4	PhoLip_ATPase_N	60..137	CDD:292826	26/56 (46%)
		ATPase-Plipid	86..1176	CDD:273734	380/1352 (28%)
		E1-E2_ATPase	142..>228	CDD:278548	24/85 (28%)
		Cation_ATPase	527..624	CDD:289987	45/335 (13%)
		HAD_like	<872..915	CDD:304363	25/43 (58%)
		PhoLip_ATPase_C	915..1169	CDD:292829	81/265 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578137
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.750