DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4301 and atp8b4

DIOPT Version :9

Sequence 1:	NP_573125.1	Gene:	CG4301 / 32610	FlyBaseID:	FBgn0030747	Length:	1342	Species:	Drosophila melanogaster
Sequence 2:	XP_002936618.2	Gene:	atp8b4 / 100145017	XenbaseID:	XB-GENE-5831431	Length:	1188	Species:	Xenopus tropicalis

Alignment Length:	1342	Identity:	407/1342 - (30%)
Similarity:	625/1342 - (46%)	Gaps:	321/1342 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QDIKKKRPKGQNRIKSTKYTLITFLPQNLLEQFRRIANFYFLVMTIISLLID-SPVSPMTSLLPL 126
            :|..:|.....|.||::||.::||||.||.|||:|:||.|||.:.|:.|:.: |.:|..|:::||
Frog    20 RDYNEKFNYANNAIKTSKYNIVTFLPINLFEQFQRVANAYFLFLLILQLIPEISSLSWFTTIVPL 84

  Fly   127 VFVIAVTAAKQGYEDILRYRTDNVVNSSPVTVIRDGKEAIIKSQDVIPGELIVVERDCDVPCDLV 191
            |.|:.:||.|...:|..|::|||.||:....|:..||....|..:|..|::|.:|.:..|..|::
Frog    85 VLVLTITAVKDATDDFFRHKTDNQVNNRQSQVLLSGKLQNEKWMNVRAGDIIKLENNQFVVADML 149

  Fly   192 LLRSTDPHGKCFITTANLDGESNLKTLMVPRDLP-TVDLPE-MHKL----GIIECESPTTDLYSF 250
            ||.|::|||.|::.||.||||:|||   |.:.|| |.||.| :.:|    |.:.||.|...|..|
Frog   150 LLSSSEPHGLCYVETAELDGETNLK---VRQALPVTADLGESITRLADFDGEVACEPPNNKLDKF 211

  Fly   251 NGKIELKGGEGRVLPLSTENVLLRGSRVKNTECVIGCAVYTGMISKLQLNSRLTRNKNASSETYI 315
            .|.:..|..:   ..|:...:||||..|:|||...|..::.|..:||..||..|:.|..|.:..:
Frog   212 TGTLIWKDNK---YSLTNSKILLRGCVVRNTEWCFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLM 273

  Fly   316 NRFLIVILVALIAIVTLL-----YFLKRYNELFVIPKLTYLGDATDSYSVKQFLQDYLSFLILFN 375
            |..::.|...||.:..:|     .:..:....|.|  ..|..:..:|.....|| .:.|::|:.|
Frog   274 NTLVLWIFGFLICMGIILAIGNSIWEHQVGSRFRI--YLYWNEVVNSSVFSGFL-TFWSYIIILN 335

  Fly   376 YLIPISLYVTIELQRVIGSWFMEWDLELYENETDQPCVVNTSNLNEELGQINILFSDKTGTLTKN 440
            .::||||||::|:.|:..|:|:.||.:::.::...|....|:.||||||||..:|||||||||:|
Frog   336 TVVPISLYVSVEVIRLGHSYFINWDRKMFYSKRGTPAETRTTTLNEELGQIEYIFSDKTGTLTQN 400

  Fly   441 EMNFQQCSINGNKFLFKKTRLEDEETKALLDINKFSANQRVFFQALSICHTVQVASGSLEQADAG 505
            .|.|.:||::|..:    ..|.||
Frog   401 IMTFNKCSVSGKVY----GELRDE----------------------------------------- 420

  Fly   506 TAKREPVTAIKSGPPEMYSISDITEESHNASQQSELNVGHTIDNSVSAHPNGVNSTIISSDVNPL 570
                                                 :|..:
Frog   421 -------------------------------------LGRKV----------------------- 425

  Fly   571 LVSDDGYGVERRKRPVVIKRSPNFARSNRMNNGAASDLNINQTDPNTVTNGVEPTTNFRPIS--- 632
                   |:..:..||      :|                                :|.|::
Frog   426 -------GITEKTAPV------DF--------------------------------SFNPLADRK 445

  Fly   633 LQFRRSTSEKDLQQSWEAPSGQAPGHRRAHSYGAPNAYLTNPVTASTPPAGVLFRSPS----TTS 693
            .||                        ..||       ||..:....|....:||..|    ..|
Frog   446 FQF------------------------YDHS-------LTEAIKLEEPYVQEVFRLLSLCHTVMS 479

  Fly   694 RESYAAPTFTRQPTILVRAESQRRKNEIRDFIFTLDYQASSPDEKALVEACANLGMVYTGDDDET 758
            .|..|.                           .|.||..||||.|||.|..|.|.::.....||
Frog   480 EEKTAG---------------------------ELVYQVQSPDEGALVTAARNFGFIFKSRTPET 517

  Fly   759 LRVRIVPPHMDYKRPFAKPREE-----TFQRLHVLEFTSDRKRMSVIVRDTDGKKWIYTKGAESY 818
            :.|                 ||     |:|.|.:|:|.:.|||||||||:.:|:..:|.|||::.
Frog   518 ITV-----------------EEMGKVVTYQLLAILDFNNIRKRMSVIVRNPEGQVKLYCKGADTI 565

  Fly   819 VFPLCANSSAELVTKTDAHISDFARLGLRTLAIARRLISEEEYQDFLVELAQANSSLENRKQLSE 883
            :|.....||.:|:..|..|:::||..||||||:|.:.:||:..:.:|....:|:::||||::...
Frog   566 LFEKLHESSEDLMYITSDHLNEFAGEGLRTLALAYKDLSEDYLKWWLKIHHEASTALENREERLA 630

  Fly   884 ECYAKIESNLDLLGATAVEDALQDDVADTLVSLQAAGIKIWVLTGDKVETALNIALSCGHIPPDA 948
            ..|.:||||:.||||||:||.||:.|.:|:.||..|.||:|:|||||.|||:||..||..:..|.
Frog   631 AAYEEIESNMMLLGATAIEDKLQEGVIETISSLLLANIKVWILTGDKQETAMNIGYSCHMLTDDM 695

  Fly   949 KKYFIM----------------ECKNREEMLLH-------------LNALDREIIFGIGQECALL 984
            .:.|::                ||...:...|:             |:.:..|.:.|   |.|::
Frog   696 NEIFVISGHTVMEVREELRKAKECTFGQSRNLYNGHQFSEKMQDTKLDTVYEETVTG---EYAMV 757

  Fly   985 IDGKSLGVAL-AEASSEFRDVAVKCTAVLCCRLSPLQKSEVVSLIKSSNENYNTASIGDGANDVS 1048
            |:|.||..|| |:...||.::|..|..|:|||::||||::||.|:|...:.. |.:|||||||:|
Frog   758 INGHSLAHALEADMEKEFLEIACMCKTVICCRVTPLQKAQVVELVKKYKKAV-TLAIGDGANDIS 821

  Fly  1049 MIQEAHVGIGIMGREGRQAARCADFAFAKFCMLKRLLLVHGHYHSVRLSLLVLYFFYKNIVFMGI 1113
            ||:.||:|:||.|:||.||...:|::||:|..|:|||||||.:...|:...:.||||||..|..:
Frog   822 MIKSAHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAFTLV 886

  Fly  1114 MFLFQFHTLFSSSSVYDSLFLTLYNVIYTSLPILFIAISEKPYTEEKLMRTPQLYKKNTDNKQLH 1178
            .|.|.|...||:.:|||..|:||:|::|||||:|.:.:.::...::..|...:||:....|...:
Frog   887 HFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNDQNCMDYTKLYEPGQLNLLFN 951

  Fly  1179 WPYFLMWVLFAIYHSVIIFYFAFCFFYYNNVLLNYGQTVA-FSCFGTLLMWTVVVVVNLKLWLES 1242
            ...|.:.:...||.|..:|:..|..|:  |.....|:.:| :..|...:..::|:||::::.|::
Frog   952 KRRFFICIAHGIYTSFALFFIPFGAFF--NTAGEDGKHIADYQSFAVTVATSLVIVVSVQIGLDT 1014

  Fly  1243 MYLS------FWYIFTIIISILGFVVTTVIYNVINLDYDTDIYWAY-------NNLLASLPVWLW 1294
            .|.:      .|....:..|||..:....|:         ||:.::       .|.|:...|||.
Frog  1015 SYWTAINHFFIWGSLAVYFSILFAMHGDGIF---------DIFPSHFPFVGNARNSLSQKSVWLV 1070

  Fly  1295 IIVTCVACLVPDYTIRMLQRALNIKSFSIFPGKQRKLKMREK 1336
            |.:|.|.|::|..|.|.|:..|:    .....|.|.|:..:|
Frog  1071 IFLTTVICVMPVLTFRFLKADLS----PTLSDKVRYLQQAKK 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4301	NP_573125.1	PhoLip_ATPase_N	57..121	CDD:292826	26/58 (45%)
		ATPase-Plipid	74..1317	CDD:273734	400/1310 (31%)
		E1-E2_ATPase	127..>345	CDD:278548	78/228 (34%)
		Cation_ATPase	<734..823	CDD:289987	35/93 (38%)
		HAD_like	<1036..1066	CDD:304363	19/29 (66%)
		PhoLip_ATPase_C	1068..1317	CDD:292829	78/262 (30%)
atp8b4	XP_002936618.2	P-type_ATPase_APLT_Dnf-like	30..973	CDD:319770	369/1180 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010