DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and DRS2

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	NP_009376.2	Gene:	DRS2 / 851207	SGDID:	S000000024	Length:	1355	Species:	Saccharomyces cerevisiae

Alignment Length:	1077	Identity:	356/1077 - (33%)
Similarity:	580/1077 - (53%)	Gaps:	102/1077 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 NRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISP---LVSLLPLLFVMIITAL 89
            |.::||||.:.||||...:::|.:....:||..:.:....:  :||   ..::..||.|:|::|:
Yeast   201 NHISTTKYNFATFLPKFLFQEFSKYANLFFLCTSAIQQVPH--VSPTNRYTTIGTLLVVLIVSAM 263

  Fly    90 KEGLEDYSRSKSDKLVNTARVTVIRNGKEEIINSQF--IVPGDLVVVRNDGDVPCDLVLLQSSSA 152
            ||.:||..|:.|||.:|.:...:.....::.:..::  |..||::.|:::..:|.|.::|.||..
Yeast   264 KECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRWIDIRVGDIIRVKSEEPIPADTIILSSSEP 328

  Fly   153 DRKCFVNTANLDGETNLKT----------ICVPTNYLLAGDHELQGKDCIVCEPSSADLYTFNGR 207
            :..|::.|||||||||||.          |.|.|.      ..:.||  :|.|..::.|||:.|.
Yeast   329 EGLCYIETANLDGETNLKIKQSRVETAKFIDVKTL------KNMNGK--VVSEQPNSSLYTYEGT 385

  Fly   208 LELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGMHTKLQLNSRYTGNKSASS 272
            :.|   ||       ..:||:.|.::|||..:::|..:.|..|:||..|||..|:..|..|..:.
Yeast   386 MTL---ND-------RQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLRNATATPIKRTAV 440

  Fly   273 EKYINRFMVALIVGMIVVVVVLYL---IERHKEAKIVPTMPYQGPPTNFNSAWQIFEDFLSFLLL 334
            ||.|||.::||...:||::::..:   |....:||.:..:..:|.    |.|...|:|||:|.:|
Yeast   441 EKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGT----NKAGLFFKDFLTFWIL 501

  Fly   335 FNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEELGQVNILFSDKTGTLT 399
            |:.:||||.::.:|:.:.:....:.:||.||.|:||.|..|..|:|.|||||:..:|||||||||
Yeast   502 FSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIEYIFSDKTGTLT 566

  Fly   400 KNLMKFVNCYVPGTNY----QLQNTHLVSEGTD---EKF-ELEK-----LDADAAVL---FEALA 448
            :|:|:|.:|.:.|..|    ....|..|.:|.:   .|| :|:|     .|.|:.::   ...||
Yeast   567 RNIMEFKSCSIAGHCYIDKIPEDKTATVEDGIEVGYRKFDDLKKKLNDPSDEDSPIINDFLTLLA 631

  Fly   449 VCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALLEGCASLGLVYEGQENDV 513
            .|||  |:.|     .:|..|:             :|||:||||.||::|.|.||..:..::.:.
Yeast   632 TCHT--VIPE-----FQSDGSI-------------KYQAASPDEGALVQGGADLGYKFIIRKPNS 676

  Fly   514 LSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQSDTIWLYSKGAESAIFPRC--KASPLVEQ 576
            :::....:.|:.:::.|::.||:|.|:|||.|.|....:|.|:.|||::.|..|.  :|:..||.
Yeast   677 VTVLLEETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEANQYVEA 741

  Fly   577 TDAQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRNELIASCYETVENELDLLGA 641
            |...:..||..||||:.:..|.:::.|...:..:|.:|.|.|.||.|.:......:|..|.|:||
Yeast   742 TMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKNLILIGA 806

  Fly   642 TALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHIPRGSKQHFIIN--TTEPAE 704
            ||:||.||:.|.||:..||.||:||||||||:.|||.|||::||.:.. .....|||  |.:..|
Yeast   807 TAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSE-DMNLLIINEETRDDTE 870

  Fly   705 --LLARLDMIGDDEPE-------VLIVDGTTITALLEHTPRQF-ADLALRCRAVLCCRLSPLQKS 759
              ||.:::.:.:.:..       .|::||.::...||.....: ..:|..|:||:|||:|||||:
Yeast   871 RNLLEKINALNEHQLSTHDMNTLALVIDGKSLGFALEPELEDYLLTVAKLCKAVICCRVSPLQKA 935

  Fly   760 EIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEMLRRLFLVH 824
            .:|.::||:...:..|||||||||||||.||:|:||:|.||.||||.||.::.:|:.|::|.|||
Yeast   936 LVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADIAVGQFKFLKKLLLVH 1000

  Fly   825 GHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSFTVLAICD 889
            |.::.||::..:|:..|||..:......|...:.:|..::..|..:..:::.:..:...|:.:.|
Yeast  1001 GSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSIMESWTMSFYNLFFTVWPPFVIGVFD 1065

  Fly   890 KDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLFNGGQTAS 954
            :..|...|..:|:|||.....:..|:.:|..||:|||....|:|..|..:......|...|:.|.
Yeast  1066 QFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIYRYGFALNMHGELAD 1130

  Fly   955 FQTFGTMLIT--IIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLY-----NLYTSGELY 1012
            ..::|..:.|  :|:::|  |..||.:..|......|..|:..:::...:|     :...|.|.|
Yeast  1131 HWSWGVTVYTTSVIIVLG--KAALVTNQWTKFTLIAIPGSLLFWLIFFPIYASIFPHANISREYY 1193

  Fly  1013 DVYNQFLSSLPIWLFTIICSVACLLPDFVIKVVNDMY 1049
            .|......|...||..|:..:..|:.||:.|....||
Yeast  1194 GVVKHTYGSGVFWLTLIVLPIFALVRDFLWKYYKRMY 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	12/37 (32%)
		ATPase-Plipid	28..1051	CDD:273734	356/1077 (33%)
		E1-E2_ATPase	84..>189	CDD:278548	35/116 (30%)
		Cation_ATPase	<489..568	CDD:289987	27/78 (35%)
		HAD_like	<758..807	CDD:304363	29/48 (60%)
		PhoLip_ATPase_C	804..1050	CDD:292829	66/253 (26%)
DRS2	NP_009376.2	ATPase-Plipid	198..1240	CDD:273734	356/1077 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810