DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9981 and Atp9a

DIOPT Version :9

Sequence 1:	NP_001259610.1	Gene:	CG9981 / 32609	FlyBaseID:	FBgn0030746	Length:	1060	Species:	Drosophila melanogaster
Sequence 2:	XP_038962655.1	Gene:	Atp9a / 84011	RGDID:	621421	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	1072	Identity:	319/1072 - (29%)
Similarity:	531/1072 - (49%)	Gaps:	117/1072 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PLRIQIGGIESRQQK-PLNRVTTTKYTWFTFLPLNFYEQFRRAVYFYFLIITIVSFFVNETISPL 74
            |..:.:|..|.|.|: |.|.:...||.:|||||...:.|||....||||::....|.....:..|
  Rat    38 PRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPGVLFSQFRYFFNFYFLLLACSQFVPEMRLGAL 102

  Fly    75 VSL-LPLLFVMIITALKEGLEDYSRSKSDKLVN-------TARVTVIRNGKEEIINSQFIVPGDL 131
            .:. :||.||:.:|.::|.:|:......||.:|       |:|.||       .:.|..|..|||
  Rat   103 YTYWVPLGFVLAVTIIREAVEEIRCYIRDKEMNSQIYSRLTSRGTV-------KVKSSNIQVGDL 160

  Fly   132 VVVRNDGDVPCDLVLLQSSSADRKCFVNTANLDGETNLK-------TICVPTNYLLAGDHELQGK 189
            ::|..:..||.|::.|::|..:..||:.|..|||||:.|       |..:||    |.| .||.:
  Rat   161 ILVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDWKLRLPVACTQRLPT----AAD-LLQIR 220

  Fly   190 DCIVCEPSSADLYTFNGRLELRSGNDGAGSSAGDALPLTIDNLLLRGVRVKSTERVVGCAIYTGM 254
            ..:..|..:.|::.|.|.. .|..:|...|.:     |:|:|.|..|. |.::..|||..:|||.
  Rat   221 SYVYAEEPNIDIHNFLGTF-TREDSDPPISES-----LSIENTLWAGT-VIASGTVVGVVLYTGR 278

  Fly   255 HTKLQLNSRYTGNKSASSEKYINRFMVALIVGMIVVVVVLYLIERHKEAKIVPTMPYQGPPTNFN 319
            ..:..:|:....:|....:..:| .:..::.|.:|||.::.:..:|                 |.
  Rat   279 ELRSVMNTSDPRSKIGLFDLEVN-CLTKILFGALVVVSLVMVALQH-----------------FA 325

  Fly   320 SAWQIFEDFLSFLLLFNYMVPISAYMNIEVYRIFGMHFMHNDLHLYDEETDQPCRVNASNLNEEL 384
            ..|.:  ..:.|||||:.::|||..:|:::.:|.....:..|..:      ....|.:|.:.|:|
  Rat   326 GRWYL--QIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKI------PGTVVRSSTIPEQL 382

  Fly   385 GQVNILFSDKTGTLTKNLMKFVNCYVPGTNYQLQN-----THLVS------------EGTDEKFE 432
            |:::.|.:|||||||:|.|.|...::....|.|.:     :|:.|            :|.....:
  Rat   383 GRISYLLTDKTGTLTQNEMVFKRLHLGTVAYGLDSMDEVQSHIFSIYTQPSQDPPAQKGPTVTTK 447

  Fly   433 LEK-LDADAAVLFEALAVCHTVEVLQEVGDKTLESSESVSEQSHLMSRNIVDRYQASSPDEKALL 496
            :.: :.:......:|:|:||.|..:.|....|   .::.:|:....|..:   ||||||||.||:
  Rat   448 VRRTMSSRVHEAVKAIALCHNVTPVYECNGVT---DQAEAEKQFEDSCRV---YQASSPDEVALV 506

  Fly   497 EGCASLGLVYEGQENDVLSICRYPSAEKVQFKRLHVLEFSSERQRMSVIVRDQS-DTIWLYSKGA 560
            :...|:||...|::...:.: |.|..:.:....|.|..|:.|.:||.:||||:| ..|..|.|||
  Rat   507 QWTESVGLTLVGRDQSSMQL-RTPGDQILNLTILQVFPFTYESKRMGIIVRDESTGEITFYMKGA 570

  Fly   561 ESAIFPRCKASPLVEQTD---AQITKYAQNGLRTMAVGRRMLTDDELFHFEELYRKANTQLSNRN 622
            :..:      :.:|:..|   .:....|:.|||.:.|.::.||:::...||..|.:|...:.:|:
  Rat   571 DVVM------AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQAKLSVHDRS 629

  Fly   623 ELIASCYETVENELDLLGATALEDALQEHVGETLEALQAAGLKIWVLTGDKVETAYNIGLACRHI 687
            ..:|:..|::|.|::||..|.:||.||..|..|||.|:.||:|:|:|||||:|||.........:
  Rat   630 LKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATCTAKNAHLV 694

  Fly   688 PRGSKQHFIINTTEPAELLARLDMIGDDEPEVLIVDGTTITALLEHTPRQFADLALRCRAVLCCR 752
            .|....|.....|...|....|:.........|::.|.::...|::...:|.:||.:|.||:|||
  Rat   695 TRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLKYYEYEFMELACQCPAVVCCR 759

  Fly   753 LSPLQKSEIVTLIKRRKKYITAAIGDGANDVSMIQEAHIGIGITGREGKQAARCADFSIARFEML 817
            .:|.||::||.|::.|...:|.|:|||.||||||||:..|:|:.|:|||||:..|||||.:|:.|
  Rat   760 CAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHL 824

  Fly   818 RRLFLVHGHYNSQRLAFLVLFYCYKNIIITGCMALYQVYDLYSATNVYNSIYLWLFDIVYISFSF 882
            .||.:|||..:.:|.|.|..|..::::.|:...|::.....:::..:|....:..:..:|..|..
  Rat   825 GRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPV 889

  Fly   883 TVLAICDKDYSEETLLSHPELYKPLAHNRQASMGVFSLWILNGFVQCFIIFFFTYAMLNDANVLF 947
            ..| :.|||...|..:.:|||||.|...|..|...|.:|:|....|...|.:       .|.:||
  Rat   890 FSL-VLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMY-------GALLLF 946

  Fly   948 NGGQTASFQTFGTMLITIIVIVGNLKLLLVAHYMTYRNFAMILASIAAFMLTTYLYNLYTSGELY 1012
            .    :.|.....:..|.:::.   :||:||  :|.:.:..::.......|..|:.:|....|..
  Rat   947 E----SEFVHIVAISFTSLILT---ELLMVA--LTIQTWHWLMTVAELLSLACYIASLVFLHEFI 1002

  Fly  1013 DVYNQFLSSLP-IWLFTIICSVACLLPDFVIK 1043
            |||  |:::|. :|..::|..|:| ||.:|:|
  Rat  1003 DVY--FIATLSFLWKVSVITLVSC-LPLYVLK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9981	NP_001259610.1	PhoLip_ATPase_N	20..66	CDD:292826	19/46 (41%)
		ATPase-Plipid	28..1051	CDD:273734	313/1054 (30%)
		E1-E2_ATPase	84..>189	CDD:278548	37/118 (31%)
		Cation_ATPase	<489..568	CDD:289987	28/79 (35%)
		HAD_like	<758..807	CDD:304363	26/48 (54%)
		PhoLip_ATPase_C	804..1050	CDD:292829	66/241 (27%)
Atp9a	XP_038962655.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	291/984 (30%)
Atp9a	XP_038962655.1	Cation_ATPase	464..571	CDD:404183	39/113 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920